INT189337

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Context Info
Confidence 0.12
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.47
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

chromosome organization (Rpa1) nucleus (Rpa1) DNA binding (Rpa1)
cytoplasm (Rpa1)
Anatomy Link Frequency
brain 1
Rpa1 (Mus musculus)
Pain Link Frequency Relevance Heat
midbrain 18 5.00 Very Low Very Low Very Low
imagery 10 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
ischemia 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
addiction 1 5.00 Very Low Very Low Very Low
Substantia nigra 1 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
medulla 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Metastasis 35 100.00 Very High Very High Very High
Parkinson's Disease 11 90.96 High High
Non-small-cell Lung Cancer 10 90.32 High High
Drug Induced Neurotoxicity 9 79.60 Quite High
Death 64 76.36 Quite High
Targeted Disruption 1 61.44 Quite High
Toxicity 7 60.00 Quite High
Cancer 30 54.32 Quite High
Brain Tumor 1 53.56 Quite High
Cockayne Syndrome 10 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As a result of these trials, RPA class I patients with a single brain metastasis are currently treated with surgical resection or SRS followed by whole-brain radiation.
Localization (resection) of RPA in brain associated with metastasis
1) Confidence 0.12 Published 2007 Journal International Journal of Nanomedicine Section Body Doc Link PMC2673824 Disease Relevance 0.79 Pain Relevance 0
RPA inhibits CSB-catalyzed ssDNA annealing
Localization (annealing) of RPA
2) Confidence 0.06 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1331990 Disease Relevance 0.06 Pain Relevance 0
In addition, co-localization of RPA with the mitochondrial marker DiOC6(3) confirmed its localization to the mitochondria.
Localization (localization) of RPA
3) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2738973 Disease Relevance 0.62 Pain Relevance 0

General Comments

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