INT18934

Context Info Confidence 0.66 First Reported 1980 Last Reported 2010 Negated 5 Speculated 0 Reported most in Body Documents 16 Total Number 19 Disease Relevance 14.71 Pain Relevance 1.29

Anatomy Link Frequency PSN1 2 GER (Homo sapiens)

Pain Link Frequency Relevance Heat Neuropeptide 1 96.96 abdominal pain 5 95.88 nud 72 95.68 Earache 1 84.44 Pain 12 78.40 Inflammation 15 60.40 Angina 2 52.32 Chronic pancreatitis 24 5.00 Paracetamol 15 5.00 chemokine 8 5.00

Disease Link Frequency Relevance Heat Gastroesophageal Reflux Disease 124 100.00 Disease 23 100.00 Occupational Lung Diseases 2 99.84 Cancer 153 99.58 Adenocarcinoma 164 98.66 Stress 7 98.52 Esophageal Disease 13 96.48 Vomiting 26 96.40 Abdominal Pain 5 95.88 Acid Reflux 19 95.76

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We speculate that detection and treatment of GER may improve the symptomatic management of patients with nonpropulsive esophageal contractions.

Gene_expression (detection) of GER associated with gastroesophageal reflux disease

1) Confidence 0.66 Published 1991 Journal Am. J. Gastroenterol. Section Abstract Doc Link 1992626 Disease Relevance 1.05 Pain Relevance 0.05

Gastroesophageal reflux (GER) is a common problem in infants but the distinction between GER and GER disease remains difficult.

Gene_expression (disease) of GER associated with gastroesophageal reflux disease and disease

2) Confidence 0.66 Published 2009 Journal Arch Pediatr Section Abstract Doc Link 19303264 Disease Relevance 1.31 Pain Relevance 0.14

Gastroesophageal reflux (GER) is a common problem in infants but the distinction between GER and GER disease remains difficult.

Gene_expression (disease) of GER associated with gastroesophageal reflux disease and disease

3) Confidence 0.66 Published 2009 Journal Arch Pediatr Section Abstract Doc Link 19303264 Disease Relevance 1.31 Pain Relevance 0.14

Although continuous 24-h pH probe monitoring was negative for GER, simultaneous pH probe and exercise stress testing (treadmill) showed a prolonged, continuous episode of acid reflux throughout exercise and the 30-min recovery phase.

Neg (negative) Gene_expression (negative) of GER associated with stress, acid reflux and gastroesophageal reflux disease

4) Confidence 0.65 Published 1987 Journal J. Pediatr. Gastroenterol. Nutr. Section Abstract Doc Link 3681587 Disease Relevance 1.04 Pain Relevance 0.10

Hyperpepsinogenemia increased the rate of GER detection in males and dyspepsia in females.

Gene_expression (detection) of GER

5) Confidence 0.65 Published 2009 Journal Ter. Arkh. Section Body Doc Link 19334482 Disease Relevance 0 Pain Relevance 0

Gastroesophageal reflux (GER) is a common problem in infants but the distinction between GER and GER disease remains difficult.

Gene_expression (disease) of GER associated with gastroesophageal reflux disease and disease

6) Confidence 0.58 Published 2009 Journal Arch Pediatr Section Abstract Doc Link 19303264 Disease Relevance 1.32 Pain Relevance 0.14

Bearing in mind the potential severity of GER disease, the audience also heard and debated the most up-to-date methods of assessing GER and treating it in patients with possibly related otorhinolaryngological symptoms.

Gene_expression (assessing) of GER associated with gastroesophageal reflux disease and disease

7) Confidence 0.53 Published 1995 Journal Int. J. Pediatr. Otorhinolaryngol. Section Abstract Doc Link 7665283 Disease Relevance 1.33 Pain Relevance 0.11

The paper also presents diagnostic methods allowing to detect GER in asthmatics.

Gene_expression (detect) of GER associated with gastroesophageal reflux disease and occupational lung diseases

8) Confidence 0.52 Published 2002 Journal Med. Sci. Monit. Section Abstract Doc Link 11887043 Disease Relevance 2.36 Pain Relevance 0.12

Manometry is useful for a study of motor disorders resulting from GER, but insufficient to determine whether or not GER is present.

Neg (not) Gene_expression (present) of GER

9) Confidence 0.52 Published 1980 Journal Nouv Presse Med Section Abstract Doc Link 7422498 Disease Relevance 0.22 Pain Relevance 0.08

The GER was expressed as the percentage change in the antral cross-sectional area between 15 and 90 min after the meal.

Gene_expression (expressed) of GER

10) Confidence 0.22 Published 2009 Journal Nutr J Section Body Doc Link PMC2704233 Disease Relevance 0 Pain Relevance 0

Western Blot analysis discriminated cancer cell lines into MxA positive (PaCa44, HPAFI, CFPAC, PSN1) or MxA negative (Ger, PT45, Panc1, Panc2, MiaPaCa2, PaCa3) (Figure 5A).

Neg (negative) Gene_expression (positive) of Ger in PSN1 associated with cancer

11) Confidence 0.11 Published 2010 Journal J Transl Med Section Body Doc Link PMC2845551 Disease Relevance 0.73 Pain Relevance 0

Western Blot analysis discriminated cancer cell lines into MxA positive (PaCa44, HPAFI, CFPAC, PSN1) or MxA negative (Ger, PT45, Panc1, Panc2, MiaPaCa2, PaCa3) (Figure 5A).

Neg (negative) Gene_expression (negative) of Ger in PSN1 associated with cancer

12) Confidence 0.11 Published 2010 Journal J Transl Med Section Body Doc Link PMC2845551 Disease Relevance 0.67 Pain Relevance 0

PDAC transduction by serial dilution of Ad-GFP resulted also in higher expression of GFP in lines not expressing MxA (Ger, PT45, Panc1, Panc2, MiaPaCa2) (Figure 5D and 5E).

Neg (not) Gene_expression (expressing) of Ger associated with adenocarcinoma

13) Confidence 0.10 Published 2010 Journal J Transl Med Section Body Doc Link PMC2845551 Disease Relevance 1.01 Pain Relevance 0

PDAC transduction by serial dilution of Ad-GFP resulted also in higher expression of GFP in lines not expressing MxA (Ger, PT45, Panc1, Panc2, MiaPaCa2) (Figure 5D and 5E).

Gene_expression (expression) of Ger associated with adenocarcinoma

14) Confidence 0.10 Published 2010 Journal J Transl Med Section Body Doc Link PMC2845551 Disease Relevance 1.02 Pain Relevance 0

Median values and quartiles are presented for the antral cross-sectional areas and the GER.

Gene_expression (presented) of GER

15) Confidence 0.10 Published 2008 Journal Nutr J Section Body Doc Link PMC2383922 Disease Relevance 0.08 Pain Relevance 0

In addition, GER and MI rose in some of our group A patients, but baseline GER and MI were already high in those patients.

Gene_expression (high) of GER

16) Confidence 0.05 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266051 Disease Relevance 0.80 Pain Relevance 0.40

GER is present in a number of children whose symptoms would not have suggested its presence.

Gene_expression (present) of GER associated with gastroesophageal reflux disease

17) Confidence 0.04 Published 2006 Journal Pediatr Radiol Section Body Doc Link PMC2663647 Disease Relevance 0.44 Pain Relevance 0

The GER was expressed as the percentage change in the antral cross-sectional area from 15 to 90 min.

Gene_expression (expressed) of GER

18) Confidence 0.04 Published 2007 Journal BMC Gastroenterol Section Body Doc Link PMC2245945 Disease Relevance 0 Pain Relevance 0

The GER was calculated using the following formula:

Gene_expression (calculated) of GER

19) Confidence 0.03 Published 2007 Journal BMC Gastroenterol Section Body Doc Link PMC2245945 Disease Relevance 0 Pain Relevance 0

General Comments

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