INT189347

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Context Info
Confidence 0.11
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 1.62
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CSNK2A1) signal transduction (CSNK2A1) plasma membrane (CSNK2A1)
nucleus (CSNK2A1) cell cycle (CSNK2A1)
CSNK2A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 130 100.00 Very High Very High Very High
imagery 4 64.92 Quite High
Hippocampus 4 53.48 Quite High
Central nervous system 20 51.80 Quite High
Neurobehavioral 2 47.20 Quite Low
Inflammation 6 34.36 Quite Low
Neuronal excitability 4 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
tetrodotoxin 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Virus Diseases 178 99.58 Very High Very High Very High
Infection 58 76.08 Quite High
Cognitive Disorder 6 55.24 Quite High
Cockayne Syndrome 30 50.00 Quite Low
Borna Disease 8 50.00 Quite Low
Neurological Disease 8 44.52 Quite Low
Disease 12 38.84 Quite Low
INFLAMMATION 6 34.36 Quite Low
Congenital Anomalies 10 5.00 Very Low Very Low Very Low
Sprains And Strains 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, phosphorylation of CSB by CKII (Figure 6A, middle panel lane 3 versus lower panel lane 3) almost completely inhibits (74% decrease) CSB-catalyzed ssDNA annealing (Figure 6C, lane 6 versus lane 11, and Figure 6D, closed circles versus open circles).
Phosphorylation (phosphorylation) of CKII
1) Confidence 0.11 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1331990 Disease Relevance 0 Pain Relevance 0
The effect of phosphorylation on CSB-catalyzed ssDNA annealing activity was examined by using CKII or PP1 to phosphorylate or dephosphorylate CSB in vitro, respectively.
Phosphorylation (phosphorylate) of CKII
2) Confidence 0.08 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1331990 Disease Relevance 0 Pain Relevance 0
The effect of phosphorylation on CSB-catalyzed ssDNA annealing activity was examined by using CKII or PP1 to phosphorylate or dephosphorylate CSB in vitro, respectively.
Phosphorylation (dephosphorylate) of CKII
3) Confidence 0.08 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1331990 Disease Relevance 0 Pain Relevance 0
BDV P is preferentially phosphorylated at serine residues 26 and 28 by PKC and, to a lesser extent, at serine residues 70 and 86 by casein kinase II (CKII) [27].
Phosphorylation (phosphorylated) of CKII associated with virus diseases and kinase c
4) Confidence 0.08 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673689 Disease Relevance 1.02 Pain Relevance 0.34
Recently, we characterized rBDV expressing P mutants lacking either the PKC or the CKII phosphorylation sites, upon replacement of the corresponding serine residues with alanines to abrogate phosphorylation [29].
Phosphorylation (phosphorylation) of CKII associated with kinase c
5) Confidence 0.08 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673689 Disease Relevance 0.60 Pain Relevance 0.23

General Comments

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