INT18935

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Context Info
Confidence 0.69
First Reported 1991
Last Reported 2010
Negated 2
Speculated 1
Reported most in Abstract
Documents 9
Total Number 10
Disease Relevance 4.91
Pain Relevance 1.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
blood 1
Gastric fundus 1
respiratory 1
GER (Homo sapiens)
Pain Link Frequency Relevance Heat
spastic colon 7 99.70 Very High Very High Very High
qutenza 3 99.64 Very High Very High Very High
Angina 2 98.04 Very High Very High Very High
Pain threshold 3 95.84 Very High Very High Very High
anesthesia 5 95.76 Very High Very High Very High
Pain 2 88.40 High High
bradykinin 5 74.48 Quite High
nociceptor 2 67.52 Quite High
Morphine 2 50.00 Quite Low
Dorsal horn 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Gastroesophageal Reflux Disease 44 100.00 Very High Very High Very High
Acid Reflux 8 100.00 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

5 99.70 Very High Very High Very High
Esophageal Motility Disorder 2 99.56 Very High Very High Very High
Asthma 1 99.12 Very High Very High Very High
Paralysis 1 98.72 Very High Very High Very High
Angina 2 98.04 Very High Very High Very High
Pain 5 95.84 Very High Very High Very High
Coronary Artery Disease 1 90.48 High High
Esophageal Disease 2 89.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
High intraperitoneal pressure produced during laparoscopic cholecystectomy (LC) is a possible source of increased GER.
Spec (possible) Positive_regulation (increased) of GER associated with acid reflux
1) Confidence 0.69 Published 1994 Journal Surg Endosc Section Abstract Doc Link 7831599 Disease Relevance 0.47 Pain Relevance 0.10
Our study could confirm no detectable basal or bethanechol-induced esophageal motility disorders in IBS patients, nor enhanced GER.
Neg (nor) Positive_regulation (enhanced) of GER associated with spastic colon and esophageal motility disorder
2) Confidence 0.67 Published 1993 Journal Dig. Dis. Sci. Section Abstract Doc Link 8093869 Disease Relevance 0.55 Pain Relevance 0.87
CONCLUSION: Our results suggest that the chronic ingestion of chilli induces GER, and that the magnitude of the induced reflux seems to be related to the kind of chilli.


Positive_regulation (induces) of GER
3) Confidence 0.60 Published 2006 Journal Dig Dis Section Body Doc Link 16699276 Disease Relevance 0.06 Pain Relevance 0
BACKGROUND: Although the ingestion of chilli has been associated with gastroesophageal reflux (GER) symptoms, there are no studies that have explored the effect of a chronic ingestion of different kinds of chilli with a variable content of capsaicin as a cause of GER.
Positive_regulation (cause) of GER associated with qutenza and gastroesophageal reflux disease
4) Confidence 0.46 Published 2006 Journal Dig Dis Section Abstract Doc Link 16699276 Disease Relevance 0.37 Pain Relevance 0.10
Gastric fundus and pyloric ligations as well as a longitudinal myelotomy at the gastroesophageal junction induced acute GER in pentobarbital-anesthetized, paralyzed, and ventilated male Sprague-Dawley rats.
Positive_regulation (induced) of GER in Gastric fundus associated with gastroesophageal reflux disease and paralysis
5) Confidence 0.43 Published 2010 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 20378832 Disease Relevance 0.86 Pain Relevance 0.26
Twenty patients (58%) had GER by pH criteria with mean values: % time pH less than 4, 40.9; %upright pH less than 4, 41; %supine pH less than 4, 44.3%; number of episodes with greater than 5 min of pH less than 4, 12.
Positive_regulation (had) of GER associated with gastroesophageal reflux disease
6) Confidence 0.40 Published 1991 Journal Am. J. Gastroenterol. Section Abstract Doc Link 1992626 Disease Relevance 1.00 Pain Relevance 0.09
A sensor-tipped catheter was used to measure esophageal pH, and GER was defined as a decrease in pH to < 4 or an increase to > 7.5.
Positive_regulation (increase) of GER
7) Confidence 0.40 Published 2005 Journal Am. J. Vet. Res. Section Body Doc Link 15822580 Disease Relevance 0.07 Pain Relevance 0
Proposed mechanisms causing GER during exertion include altered GI blood flow and motor function, neuroendocrine changes, and mechanical effects.
Positive_regulation (causing) of GER in blood associated with gastroesophageal reflux disease
8) Confidence 0.40 Published 2004 Journal Curr Sports Med Rep Section Abstract Doc Link 14980140 Disease Relevance 1.00 Pain Relevance 0.10
There was no induction of either cough or other respiratory reflexes with forced expiration during the experimental GER.
Neg (no) Positive_regulation (induction) of GER in respiratory
9) Confidence 0.08 Published 1996 Journal Bratisl Lek Listy Section Body Doc Link 8705326 Disease Relevance 0.10 Pain Relevance 0
For each calculation of the GER, the antrum diameters had been measured using only one of the above machines.
Positive_regulation (calculation) of GER
10) Confidence 0.02 Published 2007 Journal BMC Gastroenterol Section Body Doc Link PMC2245945 Disease Relevance 0 Pain Relevance 0

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