INT1894

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Context Info
Confidence 0.58
First Reported 1978
Last Reported 2010
Negated 2
Speculated 15
Reported most in Abstract
Documents 168
Total Number 184
Disease Relevance 64.12
Pain Relevance 43.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gh) signal transduction (Gh) mitochondrion (Gh)
extracellular space (Gh) extracellular region (Gh) plasma membrane (Gh)
Anatomy Link Frequency
pituitary 52
plasma 10
anterior pituitary 8
fat 6
body 6
Gh (Mus musculus)
Pain Link Frequency Relevance Heat
Clonidine 274 100.00 Very High Very High Very High
antagonist 161 100.00 Very High Very High Very High
GABAergic 9 100.00 Very High Very High Very High
Morphine 5 100.00 Very High Very High Very High
Desipramine 3 100.00 Very High Very High Very High
Somatostatin 527 99.98 Very High Very High Very High
narcan 71 99.98 Very High Very High Very High
alcohol 11 99.98 Very High Very High Very High
Potency 18 99.92 Very High Very High Very High
agonist 186 99.78 Very High Very High Very High
Disease Link Frequency Relevance Heat
Acromegaly 401 100.00 Very High Very High Very High
Syndrome 378 100.00 Very High Very High Very High
Reprotox - General 1 39 100.00 Very High Very High Very High
Galactorrhea 17 100.00 Very High Very High Very High
Thyroid Disease 7 100.00 Very High Very High Very High
Growth Hormone Deficiency 44 99.96 Very High Very High Very High
Hyperinsulinism 32 99.90 Very High Very High Very High
Growth Problems 44 99.88 Very High Very High Very High
Obesity 376 99.84 Very High Very High Very High
Multiple System Atrophy 17 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Patients treated with fluoxetine showed a significant decrease in DMI-mediated GH release irrespective of therapeutic outcome.
Negative_regulation (decrease) of Localization (release) of GH associated with desipramine and fluoxetine
1) Confidence 0.58 Published 1991 Journal Biol. Psychiatry Section Abstract Doc Link 1912129 Disease Relevance 0.08 Pain Relevance 0.63
Treatment may have reduced nocturnal GH release slightly, but treated patients still did not differ from controls.
Negative_regulation (reduced) of Localization (release) of GH
2) Confidence 0.58 Published 2005 Journal Psychoneuroendocrinology Section Body Doc Link 15358444 Disease Relevance 0 Pain Relevance 0
METHODS: To determine whether panic patients show reduced basal GH secretion, 20 patients and 12 healthy controls were studied.
Spec (whether) Negative_regulation (reduced) of Localization (secretion) of GH
3) Confidence 0.58 Published 2005 Journal Psychoneuroendocrinology Section Body Doc Link 15358444 Disease Relevance 0 Pain Relevance 0
The level of GH secretion induced by clonidine was significantly reduced after ECT, but the hypotensive responses to clonidine remained unchanged.
Negative_regulation (reduced) of Localization (secretion) of GH associated with hypotension and clonidine
4) Confidence 0.58 Published 1992 Journal Psychiatry Res Section Abstract Doc Link 1317592 Disease Relevance 0.19 Pain Relevance 0.29
Bromocriptine may correct cardiac dysfunction and carpal tunnel syndrome in acromegaly either by reduction of GH oversecretion or by a direct effect of bromocriptine on dopamine receptors in the heart and peripheral nerve endings.
Negative_regulation (reduction) of Localization (oversecretion) of GH in peripheral nerve associated with acromegaly, dopamine receptor and carpal tunnel syndrome
5) Confidence 0.58 Published 1980 Journal JAMA Section Abstract Doc Link 7420685 Disease Relevance 0.52 Pain Relevance 0.30
Reduced basal GH release would suggest an overall hypo-active GH system rather than a specific alpha-adrenergic abnormality.
Negative_regulation (Reduced) of Localization (release) of GH
6) Confidence 0.58 Published 2005 Journal Psychoneuroendocrinology Section Abstract Doc Link 15358444 Disease Relevance 0.16 Pain Relevance 0.09
However, some problems are associated with the use of growth hormone (GH) response to catecholaminergic challenge, because GH release could be decreased by a direct effect of corticosteroids at the pituitary level.
Negative_regulation (decreased) of Localization (release) of GH in pituitary associated with corticosteroid
7) Confidence 0.58 Published 2003 Journal Neuropsychobiology Section Abstract Doc Link 12759559 Disease Relevance 0.41 Pain Relevance 0.39
Growth hormone (GH) secretion is reduced with age in normal subjects.
Negative_regulation (reduced) of Localization (secretion) of Growth hormone
8) Confidence 0.56 Published 1996 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 8964853 Disease Relevance 0.31 Pain Relevance 0.06
Aging is furthermore associated with a decline in lean body mass and an increase in relative adiposity, and overt obesity is a negative determinant of GH secretion in all age groups.
Negative_regulation (determinant) of Localization (secretion) of GH in body associated with aging and obesity
9) Confidence 0.56 Published 1996 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 8964853 Disease Relevance 0.47 Pain Relevance 0.07
Studies have revealed a partial deficiency of GH secretion in the elderly.
Spec (partial) Negative_regulation (deficiency) of Localization (secretion) of GH
10) Confidence 0.55 Published 1996 Journal Fundam Clin Pharmacol Section Abstract Doc Link 8902544 Disease Relevance 0.34 Pain Relevance 0.06
It indicates that inhibition of GH secretion in patients with essential hypertension is related to coexistent obesity rather than with that of arterial hypertension.
Negative_regulation (inhibition) of Localization (secretion) of GH associated with pressure and volume under development, obesity and hypertension
11) Confidence 0.54 Published 1988 Journal Clin Exp Hypertens A Section Abstract Doc Link 3286064 Disease Relevance 1.16 Pain Relevance 0.54
A strong (r = 0.76) and significant (p less than 0.0005) correlation demonstrated between the maximal GH concentration during the nocturnal sleep and after clonidine suggests that the mechanism of GH inhibition in response to both these stimuli is similar and it probably is related to the inhibition of neurohormonal secretion of the growth hormone releasing factor (GRF).
Negative_regulation (inhibition) of Localization (secretion) of growth hormone associated with clonidine
12) Confidence 0.54 Published 1988 Journal Clin Exp Hypertens A Section Abstract Doc Link 3286064 Disease Relevance 0.81 Pain Relevance 0.50
Chronic growth hormone administration does not suppress endogenous growth hormone secretion in patients with neurosecretory growth hormone dysfunction.
Neg (not) Negative_regulation (suppress) of Localization (secretion) of growth hormone
13) Confidence 0.53 Published 1991 Journal Horm. Res. Section Title Doc Link 1806474 Disease Relevance 0 Pain Relevance 0.22
Symptoms of fibromyalgia are broadly similar to those of growth hormone deficiency (GHD), and there is evidence of decreased GH secretion and functional GHD in a subset of patients with fibromyalgia.
Negative_regulation (decreased) of Localization (secretion) of GH associated with growth hormone deficiency and fibrositis
14) Confidence 0.52 Published 2009 Journal Pediatr Endocrinol Rev Section Abstract Doc Link 19550388 Disease Relevance 1.19 Pain Relevance 0.30
The current clinically used analogs, octreotide and lanreotide, inhibit GH secretion via the somatostatin receptor subtypes 2 and 5 (Hofland and Lamberts 2003).
Negative_regulation (inhibit) of Localization (secretion) of GH associated with somatostatin
15) Confidence 0.52 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721386 Disease Relevance 0.42 Pain Relevance 0.36
Bromocriptine, a dopamine agonist, effectively reduces GH secretion in only a minority of GH-secreting adenoma (Jaffe and Barkan 1992).
Negative_regulation (reduces) of Localization (secretion) of GH associated with adenoma, dopamine and agonist
16) Confidence 0.52 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721386 Disease Relevance 0.68 Pain Relevance 0.56
Although the most important effect of somatostatin analogs is the inhibition of GH secretion by the adenoma leading to a subsequent decrease in circulating liver-derived IGF-I, part of the peripheral effects of these analogs is caused by the direct inhibition of IGF-I gene transcription after binding to the somatostatin receptor (Serri et al 1992; Murray et al 2004).
Negative_regulation (inhibition) of Localization (secretion) of GH in liver associated with adenoma and somatostatin
17) Confidence 0.52 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721386 Disease Relevance 0.40 Pain Relevance 0.32
Effects of somatostatin analogs on glucose homeostasis are the resultant of delayed intestinal absorption of carbohydrates, inhibition of insulin release and increased insulin sensitivity via diminished GH secretion.
Negative_regulation (diminished) of Localization (secretion) of GH associated with somatostatin and hyperinsulinism
18) Confidence 0.52 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721386 Disease Relevance 0.54 Pain Relevance 0.16
Basal plasma GH concentrations, effects of an experimental decrease of GH release on testicular function and an opioidergic regulation of GH release were investigated in Shetland stallions (n=6).
Negative_regulation (decrease) of Localization (release) of GH in plasma
19) Confidence 0.50 Published 2003 Journal Theriogenology Section Abstract Doc Link 12620589 Disease Relevance 0 Pain Relevance 0.08
The increase in central obesity can further inhibit GH secretion.
Negative_regulation (inhibit) of Localization (secretion) of GH associated with abdominal obesity
20) Confidence 0.50 Published 1999 Journal Semin. Reprod. Endocrinol. Section Abstract Doc Link 10851571 Disease Relevance 0.49 Pain Relevance 0

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