INT189404

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Context Info
Confidence 0.15
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.95
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
B cells 1
Igis1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 6 64.44 Quite High
aspirin 32 34.96 Quite Low
Neurotransmitter 1 10.16 Low Low
Catecholamine 1 8.80 Low Low
cINOD 7 5.00 Very Low Very Low Very Low
Inflammation 5 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
Hyperalgesia 5 5.00 Very Low Very Low Very Low
allodynia 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Asthma 26 98.24 Very High Very High Very High
Allergic Dermatitis 22 91.92 High High
Lymphatic System Cancer 1 86.32 High High
Rhinitis 68 79.20 Quite High
Eosinophilia 25 66.60 Quite High
Seasonal Allergic Rhinitis 1 64.80 Quite High
Nasal Polyps 9 47.36 Quite Low
Hypertrophy 14 46.72 Quite Low
Immunization 7 41.40 Quite Low
Neutrophil Disorders 1 28.76 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
NAC treatment of B cells from Atm-/- mice was shown to lower the increased levels of intracellular ROS and thus to rescue the impaired immunoglobulin isotype switching in these mice (Ito et al., 2007).
Negative_regulation (impaired) of immunoglobulin isotype in B cells
1) Confidence 0.15 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998772 Disease Relevance 0.09 Pain Relevance 0.03
Additional analyses were run to improve the efficiency and balance by eliminating co-variates (e.g. asthma and pulmonary function test results), redundant (individual qualitative assessments of reduced immunoglobulin isotype concentrations), and insignificant (age, gender and ethnicity) variables.
Negative_regulation (reduced) of immunoglobulin isotype associated with asthma
2) Confidence 0.01 Published 2005 Journal Respir Res Section Body Doc Link PMC1343550 Disease Relevance 0.87 Pain Relevance 0

General Comments

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