INT189438

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Context Info
Confidence 0.45
First Reported 2005
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 10
Total Number 12
Disease Relevance 4.94
Pain Relevance 0.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Kit) cell differentiation (Kit) extracellular space (Kit)
plasma membrane (Kit) nucleus (Kit) kinase activity (Kit)
Anatomy Link Frequency
melanocytes 3
stromal cell 2
stomach 2
mast cells 1
Kit (Mus musculus)
Pain Link Frequency Relevance Heat
Bioavailability 18 97.12 Very High Very High Very High
Inflammation 102 83.56 Quite High
palliative 4 72.88 Quite High
cytokine 28 61.04 Quite High
Bile 4 36.92 Quite Low
cINOD 10 5.00 Very Low Very Low Very Low
Inflammatory mediators 8 5.00 Very Low Very Low Very Low
Piles 8 5.00 Very Low Very Low Very Low
isoflurane 8 5.00 Very Low Very Low Very Low
imagery 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Anaemia 24 99.80 Very High Very High Very High
Cancer 214 99.56 Very High Very High Very High
Gastrointestinal Stromal Tumor 112 92.80 High High
Repression 5 91.72 High High
Infection 122 87.64 High High
Recurrence 15 87.40 High High
Frailty 1 86.28 High High
Sprains And Strains 34 85.84 High High
Natriuresis 2 85.60 High High
Mucositis 2 83.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nonetheless, a series of complementation assays with other known alleles including KitW, KitW-v and Kittm1Alf confirmed that Kit function was altered in Sow3 (Figure 1E).
Regulation (altered) of Gene_expression (function) of Kit
1) Confidence 0.45 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1940254 Disease Relevance 0.21 Pain Relevance 0
Involvement of the Kit-dependent steatosis and anemia in post-natal lethality
Regulation (Involvement) of Gene_expression (steatosis) of Kit-dependent associated with anaemia
2) Confidence 0.40 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1940254 Disease Relevance 0.38 Pain Relevance 0
A combined European/Australian study [2,12] has been started, in order to test the effectiveness of a new chemotherapy regimen based on imatinib mesylate STI-571: a tyrosine kinase receptors inhibitor [6], highly selective on GISTs and able to perform a "target" therapy, based on the c-KIT expression (CD117) of these tumors.
Regulation (based) of Gene_expression (expression) of c-KIT associated with cancer
3) Confidence 0.39 Published 2005 Journal World J Surg Oncol Section Body Doc Link PMC1343558 Disease Relevance 0.57 Pain Relevance 0.07
A combined European/Australian study [2,12] has been started, in order to test the effectiveness of a new chemotherapy regimen based on imatinib mesylate STI-571: a tyrosine kinase receptors inhibitor [6], highly selective on GISTs and able to perform a "target" therapy, based on the c-KIT expression (CD117) of these tumors.
Regulation (based) of Gene_expression (expression) of CD117 associated with cancer
4) Confidence 0.39 Published 2005 Journal World J Surg Oncol Section Body Doc Link PMC1343558 Disease Relevance 0.57 Pain Relevance 0.07
Several other mutants affecting the level of Kit expression have been described in the literature [2,19,23,29], unraveling that quiet a few dispersed regulatory elements control Kit gene expression.
Regulation (affecting) of Gene_expression (expression) of Kit
5) Confidence 0.27 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1940254 Disease Relevance 0 Pain Relevance 0
Several other mutants affecting the level of Kit expression have been described in the literature [2,19,23,29], unraveling that quiet a few dispersed regulatory elements control Kit gene expression.
Regulation (control) of Gene_expression (expression) of Kit
6) Confidence 0.27 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1940254 Disease Relevance 0 Pain Relevance 0
Other studies [1-3,8] also demonstrated the diagnostic role of c-KIT expression, now considered a highly specific marker for GISTs. c-KIT expression can also be used for medical therapy [2], since new drugs, (STI-571 imatinib), is characterized by a selective action on tyrosine kinase receptors, and it has been recently used with good results [6,12,13].
Regulation (role) of Gene_expression (expression) of c-KIT
7) Confidence 0.23 Published 2005 Journal World J Surg Oncol Section Body Doc Link PMC1343558 Disease Relevance 0.82 Pain Relevance 0
Other studies [1-3,8] also demonstrated the diagnostic role of c-KIT expression, now considered a highly specific marker for GISTs. c-KIT expression can also be used for medical therapy [2], since new drugs, (STI-571 imatinib), is characterized by a selective action on tyrosine kinase receptors, and it has been recently used with good results [6,12,13].
Regulation (role) of Gene_expression (expression) of c-KIT
8) Confidence 0.23 Published 2005 Journal World J Surg Oncol Section Body Doc Link PMC1343558 Disease Relevance 0.83 Pain Relevance 0
The KitW-sh allele that renders sash mice mast cell-deficient contains an inversion that abolishes Kit expression in mast cells and melanocytes but does not affect Kit expression in most other cell types [37].
Neg (not) Regulation (affect) of Gene_expression (expression) of Kit in melanocytes
9) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923184 Disease Relevance 0.41 Pain Relevance 0.19
One hypothesis considers the possible down regulation of c-kit expression by marrow cells that are unable to respond to stromal cell factors, thus compromising the generation of new lineage progenitors [35].
Spec (possible) Regulation (regulation) of Gene_expression (expression) of c-kit in stromal cell
10) Confidence 0.11 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2919407 Disease Relevance 0.67 Pain Relevance 0
The KitW-sh allele that renders sash mice mast cell-deficient contains an inversion that abolishes Kit expression in mast cells and melanocytes but does not affect Kit expression in most other cell types [37].
Neg (not) Regulation (affect) of in mast cells Gene_expression (expression) of Kit in melanocytes
11) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923184 Disease Relevance 0.41 Pain Relevance 0.19
There is thus an urgent need to modify or segregate the FDC formulation in such a way that RIF and INH are not released simultaneously in the stomach.
Regulation (segregate) of Gene_expression (formulation) of FDC in stomach
12) Confidence 0.02 Published 2006 Journal Respir Res Section Body Doc Link PMC1592088 Disease Relevance 0.06 Pain Relevance 0.08

General Comments

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