INT189445

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Context Info
Confidence 0.37
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 20
Total Number 20
Disease Relevance 3.50
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (MSLN) cell adhesion (MSLN) Golgi apparatus (MSLN)
plasma membrane (MSLN)
Anatomy Link Frequency
muscle 6
biceps brachii 4
leg 2
vastus lateralis 1
MSLN (Homo sapiens)
Pain Link Frequency Relevance Heat
Electroencephalography 21 94.60 High High
Central nervous system 31 71.56 Quite High
Pain 34 70.84 Quite High
palliative 6 57.92 Quite High
metalloproteinase 28 5.00 Very Low Very Low Very Low
Inflammation 27 5.00 Very Low Very Low Very Low
imagery 18 5.00 Very Low Very Low Very Low
backache 14 5.00 Very Low Very Low Very Low
Deep tissue 14 5.00 Very Low Very Low Very Low
nociceptor 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lung Cancer 139 99.84 Very High Very High Very High
Malignant Neoplastic Disease 51 99.44 Very High Very High Very High
Mesothelioma 150 99.04 Very High Very High Very High
Urological Neuroanatomy 21 98.64 Very High Very High Very High
Cancer 84 97.88 Very High Very High Very High
Disease 53 91.76 High High
Aging 14 91.40 High High
Loss Of Sense Of Smell 15 91.32 High High
Stress 18 79.52 Quite High
Adhesions 8 78.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In recent studies, MPF was elevated in 91% of 56 malignant mesothelioma patients compared with controls, and levels returned to normal after surgery in patients with peritoneal mesothelioma [46,48].
Positive_regulation (elevated) of MPF associated with malignant neoplastic disease and mesothelioma
1) Confidence 0.37 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2652430 Disease Relevance 1.38 Pain Relevance 0.06
In addition, there was a linear increase in MMG MPF for the biceps brachii from 10% to 100% PT.
Positive_regulation (increase) of MMG MPF in biceps brachii
2) Confidence 0.30 Published 2005 Journal Biomed Eng Online Section Body Doc Link PMC1343566 Disease Relevance 0 Pain Relevance 0
At 80% and 100% MVC, however, the training program resulted in significant increases in MMG MPF for the vastus lateralis muscle.
Positive_regulation (increases) of MMG MPF in vastus lateralis
3) Confidence 0.30 Published 2005 Journal Biomed Eng Online Section Body Doc Link PMC1343566 Disease Relevance 0.07 Pain Relevance 0
It was hypothesized that the increases in MMG amplitude and MPF from 10% to approximately 60% PT were likely due to recruitment of motor units in the biceps brachii muscle, as well as increases in their firing rates.
Positive_regulation (increases) of MPF in muscle
4) Confidence 0.30 Published 2005 Journal Biomed Eng Online Section Body Doc Link PMC1343566 Disease Relevance 0 Pain Relevance 0
These findings are in contrast to the torque-related increases in MMG amplitude and/or MPF that have been reported for the biceps brachii [26,27,63-65,67] and vastus medialis [28,66,69] during concentric and eccentric muscle actions, and may reflect muscle-specific differences in the motor control strategies that modulate torque production.
Positive_regulation (increases) of MPF in biceps brachii
5) Confidence 0.30 Published 2005 Journal Biomed Eng Online Section Body Doc Link PMC1343566 Disease Relevance 0 Pain Relevance 0
For example, during maximal concentric isokinetic leg extensions, there were velocity-related increases in MMG MPF for the rectus femoris and vastus lateralis muscles, but not for the vastus medialis [50].
Positive_regulation (increases) of MMG MPF in muscles
6) Confidence 0.30 Published 2005 Journal Biomed Eng Online Section Body Doc Link PMC1343566 Disease Relevance 0 Pain Relevance 0
There were, however, velocity-related increases in MMG MPF (marginal means, collapsed across muscles) from 240 to 300°·s-1.
Positive_regulation (increases) of MMG MPF in muscles
7) Confidence 0.30 Published 2005 Journal Biomed Eng Online Section Body Doc Link PMC1343566 Disease Relevance 0 Pain Relevance 0
Theoretically, increases in MMG MPF could reflect modulation of motor unit firing rates with increasing power output.
Positive_regulation (increases) of MMG MPF
8) Confidence 0.30 Published 2005 Journal Biomed Eng Online Section Body Doc Link PMC1343566 Disease Relevance 0 Pain Relevance 0
The increased MPF at frontal electrode sites (Fp1, Fp2, F3, F4), is largely explained by an effect on fast wave activity (20–32 Hz, also denominated as beta2 activity).
Positive_regulation (increased) of MPF
9) Confidence 0.21 Published 2008 Journal Part Fibre Toxicol Section Body Doc Link PMC2329662 Disease Relevance 0 Pain Relevance 0
It was suggested [96] that the training-induced increases in MMG MPF for the vastus lateralis muscle at 80% and 100% MVC, as well as the changes in the MMG power density spectrum, may have reflected a "retrieval" of fast-twitch motor units, which are lost in some muscles during the aging process [103].
Positive_regulation (increases) of MMG MPF in muscle associated with aging
10) Confidence 0.20 Published 2005 Journal Biomed Eng Online Section Body Doc Link PMC1343566 Disease Relevance 0.09 Pain Relevance 0
The authors [28] reported that both MMG amplitude and MPF for the vastus medialis muscle increased linearly with eccentric isokinetic torque from 10% to 100% PT.
Positive_regulation (increased) of MPF in muscle
11) Confidence 0.20 Published 2005 Journal Biomed Eng Online Section Body Doc Link PMC1343566 Disease Relevance 0 Pain Relevance 0
In addition, during the concentric muscle actions, MMG MPF for the biceps brachii increased from 0 to approximately 5.5 kg and then decreased from 5.5 to 8.5 kg [63].
Positive_regulation (increased) of MMG MPF in biceps brachii
12) Confidence 0.20 Published 2005 Journal Biomed Eng Online Section Body Doc Link PMC1343566 Disease Relevance 0 Pain Relevance 0
It was suggested that the torque-related increases in MMG amplitude and MPF for the vastus medialis may have been due to concurrent modulation of the number of active motor units and their firing rates throughout the entire range of concentric leg extension torque.
Positive_regulation (increases) of MPF in leg
13) Confidence 0.20 Published 2005 Journal Biomed Eng Online Section Body Doc Link PMC1343566 Disease Relevance 0 Pain Relevance 0
Thus, it is possible that potential increases in MMG MPF during concentric isokinetic muscle actions may be muscle- and/or velocity-specific.
Positive_regulation (increases) of MMG MPF in muscle
14) Confidence 0.20 Published 2005 Journal Biomed Eng Online Section Body Doc Link PMC1343566 Disease Relevance 0 Pain Relevance 0
The plateau in MMG amplitude, and increase in MMG MPF from 60% to 100% PT, however, suggested that recruitment in the biceps brachii muscle may have ended at approximately 60% PT, and further increases in eccentric isokinetic torque were due to changes in motor unit firing rates [67].
Positive_regulation (increase) of MMG MPF in biceps brachii
15) Confidence 0.20 Published 2005 Journal Biomed Eng Online Section Body Doc Link PMC1343566 Disease Relevance 0 Pain Relevance 0
The authors [66] reported that MMG amplitude and MPF for the vastus medialis muscle increased linearly with leg extension torque from 10% to 100% PT.
Positive_regulation (increased) of MPF in leg
16) Confidence 0.20 Published 2005 Journal Biomed Eng Online Section Body Doc Link PMC1343566 Disease Relevance 0 Pain Relevance 0
Several agents with activity in preclinical models are being developed to target mesothelin: a recombinant immunotoxin, (SS1P), a humanized monoclonal antibody (MORAb-009), and an attenuated listeria vector that encodes human mesothelin (CRS-207).
Positive_regulation (target) of mesothelin
17) Confidence 0.16 Published 2008 Journal Curr Treat Options Oncol Section Body Doc Link PMC2782121 Disease Relevance 0.78 Pain Relevance 0.07
From 30 minutes into exposure we observed a slow increase in MPF of all subjects within the exposure chamber which was stronger in diesel exhaust exposure as compared to filtered air (Fig. 1).
Positive_regulation (increase) of MPF
18) Confidence 0.14 Published 2008 Journal Part Fibre Toxicol Section Body Doc Link PMC2329662 Disease Relevance 0.09 Pain Relevance 0
The increase in MPF is primarily caused by an increase in fast wave activity (?
Positive_regulation (increase) of MPF
19) Confidence 0.14 Published 2008 Journal Part Fibre Toxicol Section Abstract Doc Link PMC2329662 Disease Relevance 0.18 Pain Relevance 0.17
Serum mesothelin levels are elevated in MM, suggesting a role in early diagnosis of this tumor in high-risk populations (Robinson, 2003), a role as marker for monitoring treatment response (Hassan, 2006), and a potential target for tumor-related therapy (Hassan, 2004).
Positive_regulation (elevated) of mesothelin associated with lung cancer and cancer
20) Confidence 0.04 Published 2007 Journal Biomarker Insights Section Body Doc Link PMC2717840 Disease Relevance 0.91 Pain Relevance 0

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