INT189477

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Context Info
Confidence 0.49
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 4.80
Pain Relevance 0.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ccr3) signal transduction (Ccr3) extracellular space (Ccr3)
plasma membrane (Ccr3) signal transducer activity (Ccr3)
Anatomy Link Frequency
cerebellum 2
cerebrum 1
brain 1
Ccr3 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 60 98.24 Very High Very High Very High
chemokine 216 82.72 Quite High
Inflammatory response 24 75.84 Quite High
Neurotransmitter 12 51.08 Quite High
cytokine 36 39.92 Quite Low
anesthesia 12 5.00 Very Low Very Low Very Low
cva 12 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
halothane 6 5.00 Very Low Very Low Very Low
isoflurane 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 258 99.98 Very High Very High Very High
INFLAMMATION 78 98.24 Very High Very High Very High
Cerebral Malaria 234 97.88 Very High Very High Very High
Malaria 288 95.12 Very High Very High Very High
Adhesions 24 86.92 High High
Brain Disease 12 86.32 High High
Pressure And Volume Under Development 18 64.04 Quite High
Apoptosis 12 63.20 Quite High
Coma 18 60.84 Quite High
Convulsion 24 60.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Sarfo and colleagues indicated that RANTES and its receptors CCR3 and CCR5 were upregulated in the cerebellum and cerebrum of post-mortem human CM tissue samples [8].
Positive_regulation (upregulated) of CCR3 in cerebrum associated with cerebral malaria
1) Confidence 0.49 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 1.61 Pain Relevance 0.20
The upregulation of RANTES, CCR1, CCR3, and CCR5 mRNA, and RANTES protein mediate inflammation and cellular degradation in the cerebellum during P. yoelii 17XL malaria.



Positive_regulation (upregulation) of CCR3 in cerebellum associated with malaria and inflammation
2) Confidence 0.33 Published 2005 Journal Malar J Section Abstract Doc Link PMC1343570 Disease Relevance 0.44 Pain Relevance 0.08
RANTES (p < 0.002), CCR1 (p < 0.036), CCR3 (p < 0.033), and CCR5 (p < 0.026) mRNA were significantly upregulated at peak parasitaemia and remained high thereafter in the experimental mouse model.
Positive_regulation (upregulated) of CCR3
3) Confidence 0.33 Published 2005 Journal Malar J Section Abstract Doc Link PMC1343570 Disease Relevance 0.50 Pain Relevance 0.07
In conclusion, P. yoelii 17XL infection upregulates RANTES and its corresponding receptors, CCR1, CCR3 and CCR5, in mouse brain, and that ultrastructural changes in the microvascular endothelial layer occurred in the cerebellum of infected mice.
Positive_regulation (upregulates) of CCR3 in brain associated with infection
4) Confidence 0.33 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 0.50 Pain Relevance 0.14
Genes encoding induced RANTES, CCR1, CCR3 and CCR5 were selectively confirmed by semi-quantitative RT-PCR.
Positive_regulation (induced) of CCR3
5) Confidence 0.33 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 0.14 Pain Relevance 0.03
Sarfo and colleagues indicated that RANTES and its receptors CCR3 and CCR5 were upregulated in the cerebellum and cerebrum of post-mortem human CM tissue samples [8].
Positive_regulation (upregulated) of CCR3 in cerebellum associated with cerebral malaria
6) Confidence 0.17 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 1.61 Pain Relevance 0.20

General Comments

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