INT189479

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Context Info
Confidence 0.31
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.06
Pain Relevance 1.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Darc) signal transducer activity (Darc)
Anatomy Link Frequency
brain 2
smooth muscle cells 2
neutrophil 2
Darc (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 87 100.00 Very High Very High Very High
cytokine 21 100.00 Very High Very High Very High
Inflammation 54 98.60 Very High Very High Very High
imagery 29 93.20 High High
Nicotine 96 75.48 Quite High
b2 receptor 29 72.64 Quite High
depression 1 68.64 Quite High
agonist 19 50.00 Quite Low
dexamethasone 11 47.80 Quite Low
ischemia 2 32.72 Quite Low
Disease Link Frequency Relevance Heat
Glaucoma 112 100.00 Very High Very High Very High
Apoptosis 106 99.64 Very High Very High Very High
INFLAMMATION 63 98.60 Very High Very High Very High
Death 35 95.68 Very High Very High Very High
Ocular Hypertension 30 94.96 High High
Infection 53 90.48 High High
Adhesions 5 88.24 High High
American Trypanosomiasis 1 87.12 High High
Depression 1 68.64 Quite High
Optic Disorders 2 63.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using DARC, we have highlighted that A?
Positive_regulation (highlighted) of Gene_expression (Using) of DARC
1) Confidence 0.31 Published 2008 Journal Progress in Brain Research Section Body Doc Link PMC2603274 Disease Relevance 1.01 Pain Relevance 0
pathway in experimental glaucoma with DARC
Positive_regulation (pathway) of Gene_expression (pathway) of DARC associated with glaucoma
2) Confidence 0.31 Published 2008 Journal Progress in Brain Research Section Body Doc Link PMC2603274 Disease Relevance 1.22 Pain Relevance 0.05
We also observed increased levels of the cytokines G-CSF and, to a smaller extent, IL-6, for both the dimer and the R6K inactive mutant, indicating once again that the increased expression of these cytokines/chemokines play no role in neutrophil recruitment.
Positive_regulation (increased) of Gene_expression (expression) of chemokines in neutrophil associated with chemokine and cytokine
3) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909905 Disease Relevance 0 Pain Relevance 0.40
This increase in expression of these chemokines occurs before brain lesions developed in infected rats, implying that the induction of these chemokines could be directly responsible for the observed rat brain lesions [34].
Positive_regulation (increase) of Gene_expression (expression) of chemokines in brain associated with chemokine
4) Confidence 0.01 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 0.43 Pain Relevance 0.23
-induced expression of RANTES, chemokines and eotaxin in the airway smooth muscle cells [53].
Positive_regulation (induced) of Gene_expression (expression) of chemokines in smooth muscle cells associated with chemokine
5) Confidence 0.01 Published 2010 Journal Respir Res Section Body Doc Link PMC2845563 Disease Relevance 0.40 Pain Relevance 0.49

General Comments

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