INT189481

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Context Info
Confidence 0.45
First Reported 2005
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.97
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ccr1) plasma membrane (Ccr1) cell-cell signaling (Ccr1)
signal transducer activity (Ccr1)
Anatomy Link Frequency
brain 4
diaphragm 2
Ccr1 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 146 93.52 High High
cytokine 32 89.92 High High
Neurotransmitter 4 73.76 Quite High
cva 4 55.20 Quite High
Inflammation 48 5.00 Very Low Very Low Very Low
Inflammatory response 12 5.00 Very Low Very Low Very Low
anesthesia 6 5.00 Very Low Very Low Very Low
Inflammatory stimuli 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 116 100.00 Very High Very High Very High
Malaria 96 95.72 Very High Very High Very High
Sepsis 52 88.32 High High
Adhesions 10 87.96 High High
Stress 4 71.64 Quite High
Pressure And Volume Under Development 6 59.84 Quite High
Bacterial Pneumonia 2 58.48 Quite High
Cv General 3 Under Development 4 55.20 Quite High
Pseudomonas Infection 8 55.04 Quite High
Endotoxemia 18 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We next sought to evaluate whether the observed upregulation of CCRs in the septic diaphragm and TA is associated with altered expression of their cognate ligands, RANTES and MIP-1?
Spec (whether) Regulation (altered) of Gene_expression (expression) of RANTES in diaphragm
1) Confidence 0.45 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2676322 Disease Relevance 0.09 Pain Relevance 0.07
In addition, under control conditions, the baseline expression levels of both RANTES and MIP-1?
Regulation (under) of Gene_expression (expression) of RANTES
2) Confidence 0.45 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2676322 Disease Relevance 0.31 Pain Relevance 0.13
The expression of RANTES and its corresponding receptors, CCR1, CCR3 and CCR 5, were altered by P. yoelii 17XL infection and were significantly up-regulated (p < 0.002 for RANTES, p < 0.036 for CCR1, p < 0.033 for CCR3 and p < 0.026 for CCR5) in the brain during malaria infection.
Regulation (altered) of Gene_expression (expression) of CCR1 in brain associated with malaria and infection
3) Confidence 0.38 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 0.78 Pain Relevance 0.20
The expression of RANTES and its corresponding receptors, CCR1, CCR3 and CCR 5, were altered by P. yoelii 17XL infection and were significantly up-regulated (p < 0.002 for RANTES, p < 0.036 for CCR1, p < 0.033 for CCR3 and p < 0.026 for CCR5) in the brain during malaria infection.
Regulation (regulated) of Gene_expression (expression) of CCR1 in brain associated with malaria and infection
4) Confidence 0.38 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 0.79 Pain Relevance 0.20

General Comments

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