INT189482

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Context Info
Confidence 0.44
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.38
Pain Relevance 0.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ccr5) signal transduction (Ccr5) plasma membrane (Ccr5)
cell-cell signaling (Ccr5) cytoplasm (Ccr5) signal transducer activity (Ccr5)
Anatomy Link Frequency
brain 6
Ccr5 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 164 96.56 Very High Very High Very High
cytokine 26 89.92 High High
Neurotransmitter 6 73.76 Quite High
Inflammation 49 72.80 Quite High
cva 6 55.20 Quite High
Inflammatory response 12 50.80 Quite High
anesthesia 7 5.00 Very Low Very Low Very Low
Arthritis 7 5.00 Very Low Very Low Very Low
ischemia 5 5.00 Very Low Very Low Very Low
fibrosis 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 131 100.00 Very High Very High Very High
Cerebral Malaria 117 97.52 Very High Very High Very High
Malaria 144 97.40 Very High Very High Very High
Adhesions 15 87.96 High High
INFLAMMATION 63 77.32 Quite High
Encephalitis 3 72.80 Quite High
Stress 3 71.64 Quite High
Disease 23 67.28 Quite High
Unconsciousness 3 66.64 Quite High
Convulsion 12 65.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of RANTES and its corresponding receptors, CCR1, CCR3 and CCR 5, were altered by P. yoelii 17XL infection and were significantly up-regulated (p < 0.002 for RANTES, p < 0.036 for CCR1, p < 0.033 for CCR3 and p < 0.026 for CCR5) in the brain during malaria infection.
Regulation (regulated) of Gene_expression (expression) of CCR 5 in brain associated with malaria and infection
1) Confidence 0.44 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 0.79 Pain Relevance 0.20
The expression of RANTES and its corresponding receptors, CCR1, CCR3 and CCR 5, were altered by P. yoelii 17XL infection and were significantly up-regulated (p < 0.002 for RANTES, p < 0.036 for CCR1, p < 0.033 for CCR3 and p < 0.026 for CCR5) in the brain during malaria infection.
Regulation (altered) of Gene_expression (expression) of CCR 5 in brain associated with malaria and infection
2) Confidence 0.44 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 0.78 Pain Relevance 0.20
Recently, the up-regulated expression of RANTES and its receptors (C CR3 and CCR5) in the cerebellar and cerebral regions of post-mortem human CM brains has been reported [8].
Regulation (regulated) of Gene_expression (expression) of CCR5 in brains associated with cerebral malaria
3) Confidence 0.37 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 1.73 Pain Relevance 0.36
As shown in Fig. 4 a, Evasin-1 showed potent inhibition of ligand-induced chemotaxis of the L1.2/CCR5 transfectants.
Regulation (transfectants) of Gene_expression (chemotaxis) of CCR5
4) Confidence 0.21 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2526197 Disease Relevance 0.08 Pain Relevance 0.11

General Comments

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