INT189488

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Context Info
Confidence 0.40
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 9.26
Pain Relevance 3.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell-cell signaling (Ccr1, Ccl5) intracellular (Ccl5) cytoplasm (Ccl5)
signal transducer activity (Ccr1) signal transduction (Ccr1) extracellular space (Ccl5)
Anatomy Link Frequency
macrophages 1
monocytes 1
endothelial cells 1
eosinophils 1
basophils 1
Ccr1 (Mus musculus)
Ccl5 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 73 97.76 Very High Very High Very High
Inflammation 118 96.84 Very High Very High Very High
antagonist 3 96.24 Very High Very High Very High
Inflammatory response 36 95.52 Very High Very High Very High
chemokine 276 94.40 High High
ischemia 26 92.84 High High
anesthesia 15 5.00 Very Low Very Low Very Low
cva 14 5.00 Very Low Very Low Very Low
Neurotransmitter 14 5.00 Very Low Very Low Very Low
isoflurane 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 151 96.84 Very High Very High Very High
Reperfusion Injury 4 93.60 High High
Cv Unclassified Under Development 26 92.84 High High
Renal Disease 9 87.32 High High
Disease 30 86.76 High High
Injury 170 85.40 High High
Malaria 336 84.80 Quite High
Cerebral Malaria 273 84.12 Quite High
Sprains And Strains 21 81.12 Quite High
Infection 301 68.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RANTES binds to a variety of receptors including CCR1, CCR3 and CCR5, expressed by monocytes/macrophages, memory T-cells, eosinophils, endothelial cells, basophils and mast cells [11].
CCR1 Binding (binds) of RANTES in macrophages
1) Confidence 0.40 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 1.22 Pain Relevance 0.37
Also, CCR1 deficient mice had reduced content of the CCR1 ligands CCL3 (MIP-1alpha) and CCL5 (RANTES).
CCR1 Binding (content) of CCL5
2) Confidence 0.24 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2825552 Disease Relevance 0.74 Pain Relevance 0.67
RANTES binds to a variety of receptors including CCR1, CCR3 and CCR5, expressed by monocytes/macrophages, memory T-cells, eosinophils, endothelial cells, basophils and mast cells [11].
CCR1 Binding (binds) of RANTES in eosinophils
3) Confidence 0.14 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 1.22 Pain Relevance 0.37
RANTES binds to a variety of receptors including CCR1, CCR3 and CCR5, expressed by monocytes/macrophages, memory T-cells, eosinophils, endothelial cells, basophils and mast cells [11].
CCR1 Binding (binds) of RANTES in endothelial cells
4) Confidence 0.14 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 1.22 Pain Relevance 0.37
RANTES binds to a variety of receptors including CCR1, CCR3 and CCR5, expressed by monocytes/macrophages, memory T-cells, eosinophils, endothelial cells, basophils and mast cells [11].
CCR1 Binding (binds) of RANTES in mast cells
5) Confidence 0.14 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 1.22 Pain Relevance 0.37
RANTES binds to a variety of receptors including CCR1, CCR3 and CCR5, expressed by monocytes/macrophages, memory T-cells, eosinophils, endothelial cells, basophils and mast cells [11].
CCR1 Binding (binds) of RANTES in monocytes
6) Confidence 0.14 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 1.22 Pain Relevance 0.37
RANTES binds to a variety of receptors including CCR1, CCR3 and CCR5, expressed by monocytes/macrophages, memory T-cells, eosinophils, endothelial cells, basophils and mast cells [11].
CCR1 Binding (binds) of RANTES in memory T-cells
7) Confidence 0.14 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 1.22 Pain Relevance 0.37
RANTES binds to a variety of receptors including CCR1, CCR3 and CCR5, expressed by monocytes/macrophages, memory T-cells, eosinophils, endothelial cells, basophils and mast cells [11].
CCR1 Binding (binds) of RANTES in basophils
8) Confidence 0.14 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 1.22 Pain Relevance 0.37

General Comments

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