INT189563

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Context Info
Confidence 0.03
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.71
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (SLIT2, ROBO4) extracellular space (SLIT2) extracellular region (SLIT2)
plasma membrane (SLIT2) cytoplasm (SLIT2)
SLIT2 (Homo sapiens)
ROBO4 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 6 72.60 Quite High
metalloproteinase 15 35.68 Quite Low
Serotonin 15 5.00 Very Low Very Low Very Low
fibrosis 6 5.00 Very Low Very Low Very Low
Inflammation 6 5.00 Very Low Very Low Very Low
fluoxetine 3 5.00 Very Low Very Low Very Low
Neurotransmitter 3 5.00 Very Low Very Low Very Low
alcohol 3 5.00 Very Low Very Low Very Low
monoamine 3 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 18 90.56 High High
Hypoxia 27 82.56 Quite High
Pulmonary Hypertension 255 78.92 Quite High
Coagulation Disorder 3 21.92 Low Low
Pulmonary Emphysema 3 18.32 Low Low
Disease 42 5.00 Very Low Very Low Very Low
Hypersensitivity 18 5.00 Very Low Very Low Very Low
Cancer 15 5.00 Very Low Very Low Very Low
Fibrosis 6 5.00 Very Low Very Low Very Low
Hypertension 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ROBO4 has been shown to bind Slit-2 [33,34], but another group did not find any interaction between ROBO4 and any of the three Slit ligands [35].
Slit-2 Binding (bind) of ROBO4
1) Confidence 0.03 Published 2006 Journal Respir Res Section Body Doc Link PMC1351173 Disease Relevance 0.17 Pain Relevance 0.07
The Slit-2-ROBO4 interaction inhibits endothelial migration, partly through the extracellular-signal-regulated kinase (ERK) signalling pathway [34].
Slit-2 Binding (interaction) of ROBO4
2) Confidence 0.02 Published 2006 Journal Respir Res Section Body Doc Link PMC1351173 Disease Relevance 0.27 Pain Relevance 0.05
The Slit-2-ROBO4 interaction inhibits endothelial migration, partly through the extracellular-signal-regulated kinase (ERK) signalling pathway [34].
Slit-2 Binding (interaction) of ROBO4
3) Confidence 0.02 Published 2006 Journal Respir Res Section Body Doc Link PMC1351173 Disease Relevance 0.27 Pain Relevance 0.05

General Comments

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