INT189583

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Context Info
Confidence 0.49
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 6
Disease Relevance 4.43
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (STK11) mitochondrion (STK11) small molecule metabolic process (STK11)
nucleus (STK11) cell cycle (STK11) protein complex (STK11)
Anatomy Link Frequency
fibroblasts 1
STK11 (Homo sapiens)
Pain Link Frequency Relevance Heat
monoamine 1 89.60 High High
Neurotransmitter 1 86.24 High High
Serotonin 5 84.00 Quite High
Chronic pancreatitis 5 5.00 Very Low Very Low Very Low
metalloproteinase 5 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
fluoxetine 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Malignant Neoplastic Disease 55 99.68 Very High Very High Very High
Congenital Anomalies 1 99.50 Very High Very High Very High
Cancer 195 99.48 Very High Very High Very High
Ductal Carcinoma 90 99.26 Very High Very High Very High
Pancreatic Cancer 185 92.80 High High
Syndrome 5 90.64 High High
Pulmonary Hypertension 85 78.32 Quite High
Adenoma 75 70.64 Quite High
Disease 14 70.32 Quite High
Carcinoma 110 69.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the analysis of microdissected cells, IDC cells expressed significantly lower levels of LKB1 mRNA than did PanIN-1B or normal ductal cells (n = 12, p = 0.02; n = 8; p = 0.002, respectively; Figure 7b top).
Transcription (levels) of LKB1 associated with ductal carcinoma
1) Confidence 0.49 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2628350 Disease Relevance 0.78 Pain Relevance 0
In the analysis of cultured cells, we found significant correlation between LKB1 and LMO4 mRNA levels in primary cultured fibroblasts (n = 6, spearman test, p = 0.024; Figure 7a, top).
Transcription (levels) of LKB1 in fibroblasts
2) Confidence 0.49 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2628350 Disease Relevance 0.77 Pain Relevance 0
There was a significant correlation between LKB1 and LMO4 mRNA levels in non-malignant cells, including normal pancreatic ductal epithelia and PanIN-1B cells (n = 20, p = 0.042, Figure 7b middle), but no significant correlation in IDC cells (n = 8, p = 0.45, Figure 7b bottom).


Transcription (levels) of LKB1 associated with ductal carcinoma and malignant neoplastic disease
3) Confidence 0.49 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2628350 Disease Relevance 0.88 Pain Relevance 0
To investigate the potential role of LMO4 in pancreatic carcinogenesis, we measured LKB1 mRNA expression in cultured and microdissected cells and investigated any correlation between LKB1 and LMO4 expression.
Transcription (expression) of LKB1
4) Confidence 0.49 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2628350 Disease Relevance 0.80 Pain Relevance 0
By contrast, there was no significant correlation between LKB1 and LMO4 mRNA levels in cultured cancer cell lines (n = 14, spearman test, p = 0.33; Figure 7a bottom).
Transcription (levels) of LKB1 associated with cancer
5) Confidence 0.49 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2628350 Disease Relevance 0.77 Pain Relevance 0
In view of the vascular abnormalities found in LKB1 null mice LKB1 has been placed in the VEGF signalling pathway [65].
Transcription (placed) of LKB1 associated with congenital anomalies
6) Confidence 0.14 Published 2006 Journal Respir Res Section Body Doc Link PMC1351173 Disease Relevance 0.42 Pain Relevance 0.13

General Comments

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