INT189590

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Context Info
Confidence 0.08
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.30
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (ACVRL1)
Anatomy Link Frequency
tubes 1
astrocyte 1
ACVRL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cva 52 99.80 Very High Very High Very High
ischemia 12 88.00 High High
positron emission tomography 1 87.04 High High
antagonist 15 53.20 Quite High
cytokine 19 39.20 Quite Low
Glutamate 5 23.08 Low Low
Serotonin 5 5.00 Very Low Very Low Very Low
metalloproteinase 5 5.00 Very Low Very Low Very Low
imagery 5 5.00 Very Low Very Low Very Low
Calcium channel 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Subarachnoid Hemorrhage 45 99.80 Very High Very High Very High
Increased Venous Pressure Under Development 82 94.32 High High
Hypoxia 19 94.32 High High
Cv Unclassified Under Development 14 88.00 High High
Pulmonary Hypertension 85 86.72 High High
Pressure Volume 2 Under Development 8 82.72 Quite High
Injury 36 72.24 Quite High
Aneurism 4 70.96 Quite High
Heart Disease 2 67.20 Quite High
Rupture 2 57.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Intriguingly, ROBO4 is upregulated in mice lacking the ALK-1 gene, which is mutated in some cases of FPAH, and these mice characteristically have aberrant fusion of endothelial tubes [33].
Positive_regulation (upregulated) of ALK-1 gene in tubes
1) Confidence 0.08 Published 2006 Journal Respir Res Section Body Doc Link PMC1351173 Disease Relevance 0.29 Pain Relevance 0
This result was not necessarily predictable since ALK1 is activated by BMPs, and has been previously implicated in astrocyte development.
Positive_regulation (activated) of ALK1 in astrocyte
2) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2832687 Disease Relevance 0.07 Pain Relevance 0.03
Studies of CBF in SAH patients undergoing HHT have yielded varying results.
Positive_regulation (undergoing) of HHT associated with cva
3) Confidence 0.01 Published 2007 Journal Crit Care Section Body Doc Link PMC2206512 Disease Relevance 0.93 Pain Relevance 0.14

General Comments

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