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Context Info
Confidence 0.25
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.99
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (SPARCL1) extracellular space (SPARCL1) extracellular region (SPARCL1)
proteinaceous extracellular matrix (SPARCL1)
Anatomy Link Frequency
muscle cells 1
mast cell 1
SPARCL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 19 99.08 Very High Very High Very High
metalloproteinase 10 94.72 High High
cytokine 18 75.92 Quite High
chemokine 1 72.08 Quite High
antagonist 4 71.92 Quite High
pruritus 1 53.28 Quite High
headache 1 50.56 Quite High
Pain 1 48.96 Quite Low
Onset of action 1 43.28 Quite Low
Serotonin 10 32.36 Quite Low
Disease Link Frequency Relevance Heat
Pulmonary Hypertension 170 100.00 Very High Very High Very High
Emphysema 4 99.84 Very High Very High Very High
INFLAMMATION 18 99.08 Very High Very High Very High
Disease 39 98.88 Very High Very High Very High
Hypersensitivity 40 98.56 Very High Very High Very High
Asthma 50 93.76 High High
Adhesions 14 65.40 Quite High
Rhinitis 9 60.48 Quite High
Sneezing 1 55.44 Quite High
Pruritus 1 53.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The extracellular protein hevin, which was upregulated in IPAH, was significantly down regulated in emphysema reflecting the tissue destruction present in this disease.

Regulation (regulated) of hevin associated with emphysema, pulmonary hypertension and disease
1) Confidence 0.25 Published 2006 Journal Respir Res Section Body Doc Link PMC1351173 Disease Relevance 1.59 Pain Relevance 0.08
Four of the up regulated genes, magic roundabout, hevin, thrombomodulin and sucrose non-fermenting protein-related kinase-1 are expressed specifically by endothelial cells and one, muscleblind-1, by muscle cells, suggesting that they may be associated with plexiform lesions and hypertrophic arterial wall remodelling, respectively.

Regulation (regulated) of hevin in muscle cells
2) Confidence 0.11 Published 2006 Journal Respir Res Section Abstract Doc Link PMC1351173 Disease Relevance 0.49 Pain Relevance 0.05
One target in the mast cell that is critical for degranulation is Syk kinase.
Regulation (target) of mast in mast cell
3) Confidence 0.01 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2946700 Disease Relevance 0.91 Pain Relevance 0.27

General Comments

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