INT189605

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Context Info
Confidence 0.33
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.65
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (EGLN1) nucleus (EGLN1) cytoplasm (EGLN1)
EGLN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 10 5.00 Very Low Very Low Very Low
Serotonin 10 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
fibrosis 4 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
fluoxetine 2 5.00 Very Low Very Low Very Low
Neurotransmitter 2 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
monoamine 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 18 99.96 Very High Very High Very High
Pulmonary Hypertension 170 95.60 Very High Very High Very High
Hypertension 4 92.64 High High
Metastasis 2 86.48 High High
Cancer 10 85.88 High High
Lung Cancer 2 84.80 Quite High
Increased Venous Pressure Under Development 2 83.68 Quite High
Adhesions 12 71.80 Quite High
Coagulation Disorder 2 46.56 Quite Low
Disease 28 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PHD2 is the key oxygen sensor involved in setting a low steady-state level of HIF-1?
Regulation (involved) of PHD2
1) Confidence 0.33 Published 2006 Journal Respir Res Section Body Doc Link PMC1351173 Disease Relevance 0.86 Pain Relevance 0
However, there is a feedback loop whereby the HIF-1 complex, formed under conditions of hypoxia, upregulates PHD2 [43].
Regulation (upregulates) of PHD2 associated with hypoxia
2) Confidence 0.29 Published 2006 Journal Respir Res Section Body Doc Link PMC1351173 Disease Relevance 0.79 Pain Relevance 0

General Comments

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