INT189614

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Context Info
Confidence 0.49
First Reported 2006
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 4.30
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (EGLN1) nucleus (EGLN1) cytoplasm (EGLN1)
EGLN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
headache 3 70.48 Quite High
metalloproteinase 25 5.00 Very Low Very Low Very Low
Serotonin 25 5.00 Very Low Very Low Very Low
cytokine 14 5.00 Very Low Very Low Very Low
fibrosis 10 5.00 Very Low Very Low Very Low
Inflammation 10 5.00 Very Low Very Low Very Low
fluoxetine 5 5.00 Very Low Very Low Very Low
Neurotransmitter 5 5.00 Very Low Very Low Very Low
alcohol 5 5.00 Very Low Very Low Very Low
monoamine 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 45 100.00 Very High Very High Very High
Pulmonary Hypertension 425 99.84 Very High Very High Very High
Metastasis 5 92.20 High High
Cancer 27 91.36 High High
Lung Cancer 5 90.52 High High
Hypertension 11 81.92 Quite High
Cirrhosis 1 80.64 Quite High
Increased Venous Pressure Under Development 5 78.20 Quite High
Adhesions 30 77.52 Quite High
Fatty Liver 1 73.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The EGLN1 gene encodes the hypoxia-inducible factor prolyl hydroxylase 2 (PHD2), one of three closely related prolyl hydroxylases found in humans.
Gene_expression (encodes) of PHD2 associated with hypoxia
1) Confidence 0.49 Published 2006 Journal Respir Res Section Body Doc Link PMC1351173 Disease Relevance 0.81 Pain Relevance 0
The EGLN1 gene encodes the hypoxia-inducible factor prolyl hydroxylase 2 (PHD2), one of three closely related prolyl hydroxylases found in humans.
Gene_expression (encodes) of EGLN1 gene associated with hypoxia
2) Confidence 0.49 Published 2006 Journal Respir Res Section Body Doc Link PMC1351173 Disease Relevance 0.80 Pain Relevance 0
The EGLN1 gene encodes the hypoxia-inducible factor prolyl hydroxylase 2 (PHD2), one of three closely related prolyl hydroxylases found in humans.
Gene_expression (encodes) of hypoxia-inducible factor prolyl hydroxylase 2 associated with hypoxia
3) Confidence 0.49 Published 2006 Journal Respir Res Section Body Doc Link PMC1351173 Disease Relevance 0.81 Pain Relevance 0
We speculate that not only does PHD2 prevent transcription of hypoxia-induced genes by hydroxylating HIF-1?
Neg (prevent) Gene_expression (prevent) of PHD2 associated with hypoxia
4) Confidence 0.49 Published 2006 Journal Respir Res Section Body Doc Link PMC1351173 Disease Relevance 0.51 Pain Relevance 0
The reason for the increase in expression of EGLN1 in IPAH is unknown.
Gene_expression (expression) of EGLN1 associated with pulmonary hypertension
5) Confidence 0.44 Published 2006 Journal Respir Res Section Body Doc Link PMC1351173 Disease Relevance 0.92 Pain Relevance 0
No mutations were found in the Von Hippel-Lindau, HIF-1alpha, HIF-2alpha, PHD1, PHD2, PHD3, and JAK2 genes.
Neg (No) Gene_expression (found) of PHD2
6) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2916842 Disease Relevance 0.46 Pain Relevance 0.12

General Comments

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