INT189625

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Context Info
Confidence 0.33
First Reported 2006
Last Reported 2007
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.49
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (SLIT2) extracellular space (SLIT2) extracellular region (SLIT2)
plasma membrane (SLIT2) cytoplasm (SLIT2)
SLIT2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 4 71.64 Quite High
metalloproteinase 10 34.72 Quite Low
Serotonin 10 5.00 Very Low Very Low Very Low
fibrosis 4 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
fluoxetine 2 5.00 Very Low Very Low Very Low
Neurotransmitter 2 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
monoamine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 12 89.60 High High
Hypoxia 18 82.56 Quite High
Pulmonary Hypertension 170 77.96 Quite High
Shock 1 53.28 Quite High
Coagulation Disorder 2 21.92 Low Low
Pulmonary Emphysema 2 17.36 Low Low
Heart Rate Under Development 1 7.36 Low Low
Disease 31 5.00 Very Low Very Low Very Low
Hypersensitivity 12 5.00 Very Low Very Low Very Low
Cardiovascular Disease 11 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In our GWAS of Echo traits, a SNP in SLIT2 was associated with Echo LV diastolic dimension in several analyses.
SLIT2 Spec (analyses) Binding (associated) of
1) Confidence 0.33 Published 2007 Journal BMC Med Genet Section Body Doc Link PMC1995617 Disease Relevance 0.05 Pain Relevance 0
The Slit-2-ROBO4 interaction inhibits endothelial migration, partly through the extracellular-signal-regulated kinase (ERK) signalling pathway [34].
Slit-2 Binding (interaction) of
2) Confidence 0.06 Published 2006 Journal Respir Res Section Body Doc Link PMC1351173 Disease Relevance 0.27 Pain Relevance 0.05
ROBO4 has been shown to bind Slit-2 [33,34], but another group did not find any interaction between ROBO4 and any of the three Slit ligands [35].
Slit-2 Binding (bind) of
3) Confidence 0.04 Published 2006 Journal Respir Res Section Body Doc Link PMC1351173 Disease Relevance 0.17 Pain Relevance 0.07

General Comments

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