INT18963

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Context Info
Confidence 0.10
First Reported 1991
Last Reported 2007
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.12
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
macrophages 1
monocytes 1
Fcr (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 14 96.16 Very High Very High Very High
cytokine 54 88.68 High High
dexamethasone 3 73.08 Quite High
headache 2 55.44 Quite High
cINOD 2 9.80 Low Low
Inflammatory response 2 9.20 Low Low
Central nervous system 7 5.00 Very Low Very Low Very Low
Hippocampus 3 5.00 Very Low Very Low Very Low
palliative 2 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Immunization 1 98.20 Very High Very High Very High
Targeted Disruption 48 96.44 Very High Very High Very High
INFLAMMATION 18 96.16 Very High Very High Very High
Cold Sores 215 89.92 High High
Infection 198 89.60 High High
Alzheimer's Dementia 85 81.64 Quite High
Colon Cancer 2 76.12 Quite High
Advanced Or Metastatic Breast Cancer 14 75.80 Quite High
Cancer 31 75.00 Quite High
Necrosis 8 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, it has been noted that deletion of the Fc receptor (the primary receptor for microglial opsinization of antibody┬ľantigen complexes) in APP transgenic mouse models has no impact on the effectiveness of antibody-mediated therapy [56,57].
Gene_expression (deletion) of Fc receptor associated with targeted disruption
1) Confidence 0.10 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1283364 Disease Relevance 0.60 Pain Relevance 0
The expression of cell surface proteins on monocytes, including HLA-DR, HLA-DQ, beta 2-microglobulin, and the Fc receptor, and serum interleukin-1 activity also were not significantly increased by the administration of TNF.
Gene_expression (expression) of Fc receptor in monocytes
2) Confidence 0.06 Published 1991 Journal Cancer Res. Section Abstract Doc Link 1998956 Disease Relevance 0.69 Pain Relevance 0.16
This was validated in a mouse model where a significant reduction in trastuzumab efficacy was observed in mice lacking the Fc receptor (Clynes et al 2006).
Neg (lacking) Gene_expression (lacking) of Fc receptor
3) Confidence 0.04 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721347 Disease Relevance 0.25 Pain Relevance 0
As this, some other effects of IL-4 are stimulating, in that it furthermore activates other Th2-like effects such as B cell class-switching and expression of mannose receptor and Fc receptor for IgE on macrophages [276].
Gene_expression (expression) of Fc receptor in macrophages
4) Confidence 0.04 Published 2005 Journal Virol J Section Body Doc Link PMC1215526 Disease Relevance 0.58 Pain Relevance 0.18

General Comments

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