INT18967

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Context Info
Confidence 0.49
First Reported 1991
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 14
Total Number 14
Disease Relevance 13.56
Pain Relevance 5.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (HLA-DRB1) Golgi apparatus (HLA-DRB1) endoplasmic reticulum (HLA-DRB1)
plasma membrane (HLA-DRB1)
Anatomy Link Frequency
monocytes 5
macrophages 4
CD86 3
cerebrospinal fluid 2
blood 2
HLA-DRB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Angina 46 99.84 Very High Very High Very High
intrathecal 1 99.62 Very High Very High Very High
headache 6 98.94 Very High Very High Very High
corticosteroid 26 96.00 Very High Very High Very High
methotrexate 3 95.20 Very High Very High Very High
cINOD 11 91.92 High High
rheumatoid arthritis 6 91.00 High High
metalloproteinase 1 89.28 High High
Multiple sclerosis 54 87.72 High High
Neuritis 4 86.84 High High
Disease Link Frequency Relevance Heat
Congenital Anomalies 3 99.96 Very High Very High Very High
Cv General 3 Under Development 40 99.84 Very High Very High Very High
Stable Angina Pectoris 6 99.52 Very High Very High Very High
Hookworm Infection 35 99.46 Very High Very High Very High
Disease 55 99.32 Very High Very High Very High
Nicotine Addiction 91 98.58 Very High Very High Very High
Occupational Lung Diseases 18 97.32 Very High Very High Very High
Pulmonary Disease 105 96.92 Very High Very High Very High
Hypersensitivity 7 96.88 Very High Very High Very High
Rheumatoid Arthritis 6 91.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
B cells transiently transfected with the HLA-DRB1*15 gene promoter showed increased expression on stimulation with 1,25-dihydroxyvitamin D3 (P?
Positive_regulation (transfected) of Gene_expression (transfected) of HLA-DRB1*15 in B cells
1) Confidence 0.49 Published 2009 Journal PLoS Genetics Section Abstract Doc Link PMC2627899 Disease Relevance 0.48 Pain Relevance 0.14
Different mechanisms appear to be involved in sHLA-DR production or release, as their level correlates positively with disease activity under combined therapy with corticosteroids and methotrexate, but decreases with higher disease activity in patients treated with NSAIDs.
Positive_regulation (involved) of Gene_expression (production) of sHLA-DR associated with corticosteroid, cinod, disease and methotrexate
2) Confidence 0.49 Published 2002 Journal Hum. Immunol. Section Abstract Doc Link 12175730 Disease Relevance 1.08 Pain Relevance 0.80
Treatment resulted in a decrease in the concentration of myelin basic protein, a decrease in the serum concentration of immunoglobulin G (IgG) and intrathecal IgG synthesis, an increase in the cerebrospinal fluid concentration of transforming growth factor-beta1, and changes in the expression of CD25, CD26, and human leukocyte antigen-DR (HLA-DR) on CD4 T-cells.
Positive_regulation (increase) of Gene_expression (expression) of antigen-DR in T-cells associated with intrathecal
3) Confidence 0.33 Published 2000 Journal Eur. J. Neurol. Section Abstract Doc Link 10886311 Disease Relevance 0.65 Pain Relevance 0.62
We have recently observed that O3 exposure can also result in increased expression of CD11b, CD14, CD16, CD80, CD86, and HLA-DR on airway dendritic cells (DCs), monocytes, and macrophages (Alexis et al. 2004b).
Positive_regulation (result) of in CD86 Gene_expression (expression) of HLA-DR in macrophages
4) Confidence 0.15 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2430237 Disease Relevance 1.14 Pain Relevance 0.14
We have recently observed that O3 exposure can also result in increased expression of CD11b, CD14, CD16, CD80, CD86, and HLA-DR on airway dendritic cells (DCs), monocytes, and macrophages (Alexis et al. 2004b).
Positive_regulation (increased) of Gene_expression (expression) of HLA-DR in macrophages
5) Confidence 0.15 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2430237 Disease Relevance 1.14 Pain Relevance 0.14
The expression of cell surface proteins on monocytes, including HLA-DR, HLA-DQ, beta 2-microglobulin, and the Fc receptor, and serum interleukin-1 activity also were not significantly increased by the administration of TNF.
Neg (not) Positive_regulation (increased) of Gene_expression (expression) of HLA-DR in monocytes
6) Confidence 0.13 Published 1991 Journal Cancer Res. Section Abstract Doc Link 1998956 Disease Relevance 0.69 Pain Relevance 0.16
The mean fluorescent intensity of monocytes positive for HLA-DR and Fc receptor expression also increased significantly in both groups, as did serum beta 2-microglobulin expression and indoleamine 2,3-dioxygenase activity.
Positive_regulation (positive) of Gene_expression (expression) of HLA-DR in monocytes
7) Confidence 0.11 Published 1993 Journal Cancer Res. Section Abstract Doc Link 8443808 Disease Relevance 0.20 Pain Relevance 0.07
These same hookworm-infected individuals also presented significantly down-regulated expression of CD86, CD1a, HLA-ABC, and HLA-DR.
Positive_regulation (presented) of Gene_expression (expression) of HLA-DR in CD86 associated with hookworm infection
8) Confidence 0.09 Published 2009 Journal PLoS Neglected Tropical Diseases Section Abstract Doc Link PMC2654967 Disease Relevance 0.58 Pain Relevance 0
MSCs isolated from the BM showed expression of HLA DR, while those isolated from the umbilical cord blood and cord matrix were negative for HLA DR expression.
Positive_regulation (negative) of Gene_expression (expression) of HLA DR in blood
9) Confidence 0.09 Published 2010 Journal Asian Journal of Transfusion Science Section Body Doc Link PMC2847339 Disease Relevance 0.05 Pain Relevance 0
We have recently observed that O3 exposure can also result in increased expression of CD11b, CD14, CD16, CD80, CD86, and HLA-DR on airway dendritic cells (DCs), monocytes, and macrophages (Alexis et al. 2004b).
Positive_regulation (increased) of in monocytes Gene_expression (expression) of HLA-DR in macrophages
10) Confidence 0.05 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2430237 Disease Relevance 1.14 Pain Relevance 0.14
Moreover, compared to never-smokers, the expansion and activation of airway CD8+ lymphocytes, in terms of increased expression of CD69, HLA-DR and CD25, have been demonstrated in smokers without a clinical diagnosis of COPD (12).
Positive_regulation (increased) of Gene_expression (expression) of HLA-DR in lymphocytes associated with pulmonary disease and nicotine addiction
11) Confidence 0.05 Published 2010 Journal Respir Res Section Body Doc Link PMC2955660 Disease Relevance 1.33 Pain Relevance 0.03
Parkinson's disease and immunological abnormalities: increase of HLA-DR expression on monocytes in cerebrospinal fluid and of CD45RO+ T cells in peripheral blood.
Positive_regulation (increase) of Gene_expression (expression) of HLA-DR in cerebrospinal fluid associated with congenital anomalies, headache and disease
12) Confidence 0.04 Published 1994 Journal Acta Neurol. Scand. Section Title Doc Link 7847055 Disease Relevance 0.91 Pain Relevance 0.36
The serum levels of CRP and percentages of HLA-DR, CD14, and CD16+56 were higher in UAP class II than UAP class I.
Positive_regulation (higher) of Gene_expression (levels) of HLA-DR associated with angina
13) Confidence 0.02 Published 2002 Journal Jpn Heart J Section Abstract Doc Link 12558124 Disease Relevance 2.16 Pain Relevance 1.76
The serum levels of CRP and percentages of HLA-DR, CD14, and CD16+56 were higher in UAP class III than UAP class II and UAP class I.
Positive_regulation (higher) of Gene_expression (levels) of HLA-DR associated with angina
14) Confidence 0.02 Published 2002 Journal Jpn Heart J Section Abstract Doc Link 12558124 Disease Relevance 2.02 Pain Relevance 1.63

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