INT189671

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Context Info
Confidence 0.12
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.71
Pain Relevance 0.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (DAG1, PRKCA) cytoplasm (DAG1, PRKCA) nucleus (DAG1, PRKCA)
plasma membrane (DAG1, PRKCA) mitochondrion (PRKCA) small molecule metabolic process (PRKCA)
DAG1 (Homo sapiens)
PRKCA (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 74 100.00 Very High Very High Very High
Calcium channel 1 97.80 Very High Very High Very High
agonist 11 58.76 Quite High
Bioavailability 2 58.40 Quite High
Inflammation 35 50.00 Quite Low
cytokine 14 5.00 Very Low Very Low Very Low
bradykinin 3 5.00 Very Low Very Low Very Low
spinal inflammation 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
rheumatoid arthritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperglycemia 38 99.50 Very High Very High Very High
Apoptosis 93 87.08 High High
Targeted Disruption 3 81.92 Quite High
Diabetic Retinopathy 3 77.60 Quite High
Stress 31 70.00 Quite High
Hypoxia 1 61.04 Quite High
INFLAMMATION 36 50.00 Quite Low
Diabetes Mellitus 83 18.80 Low Low
Insulin Resistance 27 18.28 Low Low
Metabolic Syndrome 15 17.48 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since previous studies have shown that Receptor Ck activation leads to the generation of the second messenger, phosphatidic acid (PA) [22] and since PA can be dephosphorylated by the enzyme phosphatidic acid phosphohydrolase (PAP) to give rise to diacylglycerol (DAG), which is an endogenous activator of protein kinase C (PKC) [25,26], we hypothesized that PA, DAG and PKC may be involved in the Receptor Ck dependent transcriptional regulation of c-myc, PPAR?
DAG Positive_regulation (activator) of PKC associated with kinase c
1) Confidence 0.12 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.16 Pain Relevance 0.30
DAG is able to activate PKC, which in turn activates membrane markers up-regulation and histamine release [39].
DAG Positive_regulation (activate) of PKC associated with kinase c
2) Confidence 0.04 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2949734 Disease Relevance 0 Pain Relevance 0.20
Hyperglycemia increases the levels of DAG, which in turn activates PKC.
DAG Positive_regulation (activates) of PKC associated with hyperglycemia and kinase c
3) Confidence 0.01 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2903979 Disease Relevance 0.56 Pain Relevance 0.33

General Comments

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