INT189687

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Context Info
Confidence 0.00
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.24
Pain Relevance 0.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (TERT) DNA binding (TERT) cytoplasm (TERT)
RNA binding (TERT) chromosome (TERT) nucleolus (TERT)
Anatomy Link Frequency
somatic cells 2
INSRR (Homo sapiens)
TERT (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 94 99.44 Very High Very High Very High
agonist 8 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 8 97.12 Very High Very High Very High
Cancer 32 73.36 Quite High
Aging 8 5.00 Very Low Very Low Very Low
Apoptosis 6 5.00 Very Low Very Low Very Low
Reprotox - General 1 4 5.00 Very Low Very Low Very Low
Targeted Disruption 4 5.00 Very Low Very Low Very Low
Hyperplasia 2 5.00 Very Low Very Low Very Low
Cervical Cancer 2 5.00 Very Low Very Low Very Low
Genetic Translocation 2 5.00 Very Low Very Low Very Low
Chromosomal Instability 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
By using specific activator and inhibitor of protein kinase C (PKC), it was demonstrated that Receptor Ck dependent down-regulation of hTERT gene transcription involved inhibition of PKC.
Receptor Negative_regulation (regulation) of Transcription (transcription) of hTERT associated with kinase c
1) Confidence 0.00 Published 2006 Journal BMC Cell Biol Section Abstract Doc Link PMC1351175 Disease Relevance 0.07 Pain Relevance 0.15
The Receptor Ck dependent down-regulation of hTERT transcription observed in normal human PBMCs may reflect a general mechanism for the repression of hTERT and telomerase expression in normal somatic cells.
Receptor Negative_regulation (regulation) of Transcription (transcription) of hTERT in somatic cells associated with repression
2) Confidence 0.00 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.17 Pain Relevance 0.21

General Comments

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