INT18969

Context Info Confidence 0.65 First Reported 1991 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 29 Total Number 29 Disease Relevance 12.19 Pain Relevance 2.54

endosome (HLA-DQA1) Golgi apparatus (HLA-DQA1) endoplasmic reticulum (HLA-DQA1) plasma membrane (HLA-DQA1)

Anatomy Link Frequency leukocyte 5 CD86 3 lymphocytes 2 NK cell 2 T cells 2 HLA-DQA1 (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 82 98.72 endometriosis 2 98.48 Dismenorea 1 97.76 Patient controlled epidural analgesia 2 91.80 Multiple sclerosis 48 89.96 chemokine 8 89.92 Morphine 2 89.64 analgesia 10 89.00 cINOD 3 88.64 epidural 14 81.60

Disease Link Frequency Relevance Heat Disease 408 100.00 Malabsorption Syndromes 116 100.00 Enteropathy 21 100.00 Adhesions 4 100.00 Celiac Disease 126 99.88 Skin Cancer 90 98.56 Endometriosis (extended) 4 98.48 Hemorrhage 22 98.44 Neonatal Alloimmune Thrombocytopenia 28 98.16 Dysmenorrhea 1 97.76

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

However, they allow the detection of patients with both celiac disease and IgA deficiency.

Gene_expression (disease) of celiac associated with malabsorption syndromes

1) Confidence 0.65 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1435993 Disease Relevance 0.22 Pain Relevance 0

Peripheral blood lymphocytes (PBLs) express HLA class I antigens and are used for the serologic typing of HLA-A, HLA-B, and HLA-C.

Gene_expression (express) of HLA class I in lymphocytes

2) Confidence 0.44 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628004 Disease Relevance 0.05 Pain Relevance 0

HLA class I molecules are expressed on the surface of almost all nucleated cells.

Gene_expression (expressed) of HLA class I

3) Confidence 0.44 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628004 Disease Relevance 0.13 Pain Relevance 0

[Comparative study of HLA-DQA1 and HLA-DRB1 allele in patients with endometriosis and adenomyosis].

Gene_expression (study) of HLA-DQA1 associated with endometriosis and dismenorea

4) Confidence 0.38 Published 2002 Journal Zhonghua Yi Xue Yi Chuan Xue Za Zhi Section Title Doc Link 11836687 Disease Relevance 0.20 Pain Relevance 0.19

Several case reports, however, suggest that HLA class I antibodies may occasionally be involved.73

Gene_expression (antibodies) of HLA class I

5) Confidence 0.38 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628004 Disease Relevance 0.98 Pain Relevance 0.06

Currently studies are underway to elucidate the potential benefits and risks of mismatches in the NK-cell receptors and their HLA class I ligands, especially HLA-C molecules.52,53

Gene_expression (ligands) of HLA class I

6) Confidence 0.38 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628004 Disease Relevance 0.43 Pain Relevance 0

Extending the region to 864 kb between HLA-E and HLA-B, 4 of the same HLA class I haplotypes found in Panel 1 individuals and 4 other statistically significant class I haplotypes were found (Fig. 1, column C).

Gene_expression (found) of HLA class I

7) Confidence 0.37 Published 2007 Journal BMC Genet Section Body Doc Link PMC1853106 Disease Relevance 0 Pain Relevance 0

The products of the class II genes DR, DP, and DQ, are heterodimers of two noncovalently associated glycosylated polypeptide chains; ?

Gene_expression (products) of DQ

8) Confidence 0.34 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628004 Disease Relevance 0 Pain Relevance 0

Platelets express platelet-specific antigens and HLA class I antigens.

Gene_expression (express) of HLA class I in platelet

9) Confidence 0.34 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628004 Disease Relevance 0.76 Pain Relevance 0

NK cells have been known to recognize the loss of expression of HLA class I molecules (i.e., missing self) and destroy cells with decreased expression of class I molecules such as some tumors and virally infected cells.

Gene_expression (expression) of HLA class I in NK cells associated with cancer

10) Confidence 0.34 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628004 Disease Relevance 0.10 Pain Relevance 0

Furthermore, human leukocyte antigen classes I and II, intercellular adhesion molecule-1, as well as costimulatory molecules B7-1, B7-2, and CD40, all of which are known not to be expressed in cardiac myocytes under normal conditions, were moderately to strongly expressed in cardiac myocytes.

Neg (not) Gene_expression (expressed) of leukocyte antigen classes I and II in leukocyte associated with adhesions

11) Confidence 0.32 Published 1999 Journal Jpn. Circ. J. Section Abstract Doc Link 10084393 Disease Relevance 0.94 Pain Relevance 0.07

They concluded that in a general population, the best screening test for detection of GSE is IgA tTG-antibody.[18] Therefore, most anti-tTG positive cases in recently published reports from Iran had low titers in serologic testing and Marsh III stage in histological evaluation.

Gene_expression (detection) of GSE associated with enteropathy

12) Confidence 0.32 Published 2008 Journal Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association Section Body Doc Link PMC2702920 Disease Relevance 0.50 Pain Relevance 0

Furthermore, human leukocyte antigen classes I and II, intercellular adhesion molecule-1, as well as costimulatory molecules B7-1, B7-2, and CD40, all of which are known not to be expressed in cardiac myocytes under normal conditions, were moderately to strongly expressed in cardiac myocytes.

Gene_expression (expressed) of leukocyte antigen classes I and II in leukocyte associated with adhesions

13) Confidence 0.25 Published 1999 Journal Jpn. Circ. J. Section Abstract Doc Link 10084393 Disease Relevance 0.94 Pain Relevance 0.07

If HLA class I expression is normal then NK cell mediated destruction is inhibited.

Gene_expression (expression) of HLA class I in NK cell

14) Confidence 0.21 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647156 Disease Relevance 0.45 Pain Relevance 0.04

Variation in the interaction of other molecules that bind to HLA class I and monitor HLA class I expression, including leukocyte Ig-like receptors (LIRs), members of the Ly49 family (Ly49) and the CD94/NKG2 family of receptors, could also provide another mechanism by which HLA class I could lead to AID [76, 77, 83].

Gene_expression (expression) of HLA class I in leukocyte associated with autoimmune disease

15) Confidence 0.21 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647156 Disease Relevance 0.27 Pain Relevance 0.04

Variation in the interaction of other molecules that bind to HLA class I and monitor HLA class I expression, including leukocyte Ig-like receptors (LIRs), members of the Ly49 family (Ly49) and the CD94/NKG2 family of receptors, could also provide another mechanism by which HLA class I could lead to AID [76, 77, 83].

Gene_expression (expression) of HLA class I in leukocyte associated with autoimmune disease

16) Confidence 0.18 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647156 Disease Relevance 0.27 Pain Relevance 0.04

Viruses can also alter HLA class I and II expression, potentially leading to greater antigen presentation to CD8+ T cells, with certain alleles more prone to viral/bacteria manipulation [73].

Gene_expression (expression) of HLA class I and II in T cells

17) Confidence 0.16 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647156 Disease Relevance 1.01 Pain Relevance 0.09

Also, no significant difference was found in monocyte numbers or their human leukocyte antigen-DR, CD86, or CD71 expression.

Gene_expression (expression) of leukocyte antigen-DR in leukocyte

18) Confidence 0.14 Published 2004 Journal Anesth. Analg. Section Abstract Doc Link 15041604 Disease Relevance 0.59 Pain Relevance 0.88

The expression of cell surface proteins on monocytes, including HLA-DR, HLA-DQ, beta 2-microglobulin, and the Fc receptor, and serum interleukin-1 activity also were not significantly increased by the administration of TNF.

Gene_expression (expression) of HLA-DQ in monocytes

19) Confidence 0.12 Published 1991 Journal Cancer Res. Section Abstract Doc Link 1998956 Disease Relevance 0.69 Pain Relevance 0.16

Circulating cytokines, C-reactive protein (CRP), cortisol, and cell-surface receptor expression of immune cells (cluster of differentiation [CD]14, human leukocyte antigen-DR, CD86, CD71, CD3, CD4, CD8, CD16, and CD19) were measured perioperatively to characterize immunological functions.

Gene_expression (expression) of leukocyte antigen-DR in CD86 associated with cytokine

20) Confidence 0.11 Published 2004 Journal Anesth. Analg. Section Abstract Doc Link 15041604 Disease Relevance 0.47 Pain Relevance 0.67

General Comments

This test has worked.