INT18969

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Context Info
Confidence 0.65
First Reported 1991
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 29
Total Number 29
Disease Relevance 12.19
Pain Relevance 2.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (HLA-DQA1) Golgi apparatus (HLA-DQA1) endoplasmic reticulum (HLA-DQA1)
plasma membrane (HLA-DQA1)
Anatomy Link Frequency
leukocyte 5
CD86 3
lymphocytes 2
NK cell 2
T cells 2
HLA-DQA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 82 98.72 Very High Very High Very High
endometriosis 2 98.48 Very High Very High Very High
Dismenorea 1 97.76 Very High Very High Very High
Patient controlled epidural analgesia 2 91.80 High High
Multiple sclerosis 48 89.96 High High
chemokine 8 89.92 High High
Morphine 2 89.64 High High
analgesia 10 89.00 High High
cINOD 3 88.64 High High
epidural 14 81.60 Quite High
Disease Link Frequency Relevance Heat
Disease 408 100.00 Very High Very High Very High
Malabsorption Syndromes 116 100.00 Very High Very High Very High
Enteropathy 21 100.00 Very High Very High Very High
Adhesions 4 100.00 Very High Very High Very High
Celiac Disease 126 99.88 Very High Very High Very High
Skin Cancer 90 98.56 Very High Very High Very High
Endometriosis (extended) 4 98.48 Very High Very High Very High
Hemorrhage 22 98.44 Very High Very High Very High
Neonatal Alloimmune Thrombocytopenia 28 98.16 Very High Very High Very High
Dysmenorrhea 1 97.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, they allow the detection of patients with both celiac disease and IgA deficiency.
Gene_expression (disease) of celiac associated with malabsorption syndromes
1) Confidence 0.65 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1435993 Disease Relevance 0.22 Pain Relevance 0
Peripheral blood lymphocytes (PBLs) express HLA class I antigens and are used for the serologic typing of HLA-A, HLA-B, and HLA-C.
Gene_expression (express) of HLA class I in lymphocytes
2) Confidence 0.44 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628004 Disease Relevance 0.05 Pain Relevance 0
HLA class I molecules are expressed on the surface of almost all nucleated cells.
Gene_expression (expressed) of HLA class I
3) Confidence 0.44 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628004 Disease Relevance 0.13 Pain Relevance 0
[Comparative study of HLA-DQA1 and HLA-DRB1 allele in patients with endometriosis and adenomyosis].
Gene_expression (study) of HLA-DQA1 associated with endometriosis and dismenorea
4) Confidence 0.38 Published 2002 Journal Zhonghua Yi Xue Yi Chuan Xue Za Zhi Section Title Doc Link 11836687 Disease Relevance 0.20 Pain Relevance 0.19
Several case reports, however, suggest that HLA class I antibodies may occasionally be involved.73


Gene_expression (antibodies) of HLA class I
5) Confidence 0.38 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628004 Disease Relevance 0.98 Pain Relevance 0.06
Currently studies are underway to elucidate the potential benefits and risks of mismatches in the NK-cell receptors and their HLA class I ligands, especially HLA-C molecules.52,53
Gene_expression (ligands) of HLA class I
6) Confidence 0.38 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628004 Disease Relevance 0.43 Pain Relevance 0
Extending the region to 864 kb between HLA-E and HLA-B, 4 of the same HLA class I haplotypes found in Panel 1 individuals and 4 other statistically significant class I haplotypes were found (Fig. 1, column C).
Gene_expression (found) of HLA class I
7) Confidence 0.37 Published 2007 Journal BMC Genet Section Body Doc Link PMC1853106 Disease Relevance 0 Pain Relevance 0
The products of the class II genes DR, DP, and DQ, are heterodimers of two noncovalently associated glycosylated polypeptide chains; ?
Gene_expression (products) of DQ
8) Confidence 0.34 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628004 Disease Relevance 0 Pain Relevance 0
Platelets express platelet-specific antigens and HLA class I antigens.
Gene_expression (express) of HLA class I in platelet
9) Confidence 0.34 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628004 Disease Relevance 0.76 Pain Relevance 0
NK cells have been known to recognize the loss of expression of HLA class I molecules (i.e., missing self) and destroy cells with decreased expression of class I molecules such as some tumors and virally infected cells.
Gene_expression (expression) of HLA class I in NK cells associated with cancer
10) Confidence 0.34 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628004 Disease Relevance 0.10 Pain Relevance 0
Furthermore, human leukocyte antigen classes I and II, intercellular adhesion molecule-1, as well as costimulatory molecules B7-1, B7-2, and CD40, all of which are known not to be expressed in cardiac myocytes under normal conditions, were moderately to strongly expressed in cardiac myocytes.
Neg (not) Gene_expression (expressed) of leukocyte antigen classes I and II in leukocyte associated with adhesions
11) Confidence 0.32 Published 1999 Journal Jpn. Circ. J. Section Abstract Doc Link 10084393 Disease Relevance 0.94 Pain Relevance 0.07
They concluded that in a general population, the best screening test for detection of GSE is IgA tTG-antibody.[18] Therefore, most anti-tTG positive cases in recently published reports from Iran had low titers in serologic testing and Marsh III stage in histological evaluation.
Gene_expression (detection) of GSE associated with enteropathy
12) Confidence 0.32 Published 2008 Journal Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association Section Body Doc Link PMC2702920 Disease Relevance 0.50 Pain Relevance 0
Furthermore, human leukocyte antigen classes I and II, intercellular adhesion molecule-1, as well as costimulatory molecules B7-1, B7-2, and CD40, all of which are known not to be expressed in cardiac myocytes under normal conditions, were moderately to strongly expressed in cardiac myocytes.
Gene_expression (expressed) of leukocyte antigen classes I and II in leukocyte associated with adhesions
13) Confidence 0.25 Published 1999 Journal Jpn. Circ. J. Section Abstract Doc Link 10084393 Disease Relevance 0.94 Pain Relevance 0.07
If HLA class I expression is normal then NK cell mediated destruction is inhibited.
Gene_expression (expression) of HLA class I in NK cell
14) Confidence 0.21 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647156 Disease Relevance 0.45 Pain Relevance 0.04
Variation in the interaction of other molecules that bind to HLA class I and monitor HLA class I expression, including leukocyte Ig-like receptors (LIRs), members of the Ly49 family (Ly49) and the CD94/NKG2 family of receptors, could also provide another mechanism by which HLA class I could lead to AID [76, 77, 83].
Gene_expression (expression) of HLA class I in leukocyte associated with autoimmune disease
15) Confidence 0.21 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647156 Disease Relevance 0.27 Pain Relevance 0.04
Variation in the interaction of other molecules that bind to HLA class I and monitor HLA class I expression, including leukocyte Ig-like receptors (LIRs), members of the Ly49 family (Ly49) and the CD94/NKG2 family of receptors, could also provide another mechanism by which HLA class I could lead to AID [76, 77, 83].
Gene_expression (expression) of HLA class I in leukocyte associated with autoimmune disease
16) Confidence 0.18 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647156 Disease Relevance 0.27 Pain Relevance 0.04
Viruses can also alter HLA class I and II expression, potentially leading to greater antigen presentation to CD8+ T cells, with certain alleles more prone to viral/bacteria manipulation [73].
Gene_expression (expression) of HLA class I and II in T cells
17) Confidence 0.16 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647156 Disease Relevance 1.01 Pain Relevance 0.09
Also, no significant difference was found in monocyte numbers or their human leukocyte antigen-DR, CD86, or CD71 expression.
Gene_expression (expression) of leukocyte antigen-DR in leukocyte
18) Confidence 0.14 Published 2004 Journal Anesth. Analg. Section Abstract Doc Link 15041604 Disease Relevance 0.59 Pain Relevance 0.88
The expression of cell surface proteins on monocytes, including HLA-DR, HLA-DQ, beta 2-microglobulin, and the Fc receptor, and serum interleukin-1 activity also were not significantly increased by the administration of TNF.
Gene_expression (expression) of HLA-DQ in monocytes
19) Confidence 0.12 Published 1991 Journal Cancer Res. Section Abstract Doc Link 1998956 Disease Relevance 0.69 Pain Relevance 0.16
Circulating cytokines, C-reactive protein (CRP), cortisol, and cell-surface receptor expression of immune cells (cluster of differentiation [CD]14, human leukocyte antigen-DR, CD86, CD71, CD3, CD4, CD8, CD16, and CD19) were measured perioperatively to characterize immunological functions.
Gene_expression (expression) of leukocyte antigen-DR in CD86 associated with cytokine
20) Confidence 0.11 Published 2004 Journal Anesth. Analg. Section Abstract Doc Link 15041604 Disease Relevance 0.47 Pain Relevance 0.67

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