INT18971

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Context Info
Confidence 0.67
First Reported 1991
Last Reported 2004
Negated 1
Speculated 0
Reported most in Body
Documents 8
Total Number 13
Disease Relevance 1.91
Pain Relevance 1.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (NEUROD1) nucleus (NEUROD1) transcription factor binding (NEUROD1)
cytoplasm (NEUROD1)
Anatomy Link Frequency
macrophages 8
monocytes 4
neutrophils 4
IMR-32 2
ganglia 2
NEUROD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
sodium channel 4 100.00 Very High Very High Very High
cINOD 2 99.98 Very High Very High Very High
agonist 5 99.64 Very High Very High Very High
Pain 20 97.08 Very High Very High Very High
Catecholamine 3 95.04 Very High Very High Very High
Nicotine 1 93.00 High High
lidocaine 1 89.08 High High
dorsal root ganglion 1 87.56 High High
Analgesic 4 75.00 Quite High
dexamethasone 3 73.08 Quite High
Disease Link Frequency Relevance Heat
Pain 3 97.08 Very High Very High Very High
Congenital Anomalies 2 96.48 Very High Very High Very High
Obesity 3 95.60 Very High Very High Very High
Injury 2 95.00 High High
Thyroid Disease 2 92.60 High High
Ganglion Cysts 3 89.88 High High
Lordosis 1 79.40 Quite High
Acute Liver Failure 1 77.96 Quite High
Colon Cancer 1 76.12 Quite High
Necrosis 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The former mechanism seems to be a selective increase in the expression of the beta 2-adrenoceptors.
Positive_regulation (increase) of Gene_expression (expression) of beta 2
1) Confidence 0.67 Published 1997 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 8989252 Disease Relevance 0.51 Pain Relevance 0.24
NSAIDs upregulate beta 2-integrin expression on human neutrophils through a calcium-dependent pathway.
Positive_regulation (upregulate) of Gene_expression (expression) of beta 2 in neutrophils associated with cinod
2) Confidence 0.67 Published 1997 Journal Aliment. Pharmacol. Ther. Section Title Doc Link 9218092 Disease Relevance 0 Pain Relevance 0.19
On histology, there was increased vasodilatation, marked infiltration with neutrophils and monocytes/macrophages, and increased expression of beta 2 integrins in lesional vs. normal skin.
Positive_regulation (increased) of Gene_expression (expression) of beta 2 in macrophages
3) Confidence 0.67 Published 2004 Journal Br. J. Dermatol. Section Body Doc Link 15270877 Disease Relevance 0 Pain Relevance 0
The expression of cell surface proteins on monocytes, including HLA-DR, HLA-DQ, beta 2-microglobulin, and the Fc receptor, and serum interleukin-1 activity also were not significantly increased by the administration of TNF.
Neg (not) Positive_regulation (increased) of Gene_expression (expression) of beta 2 in monocytes
4) Confidence 0.49 Published 1991 Journal Cancer Res. Section Abstract Doc Link 1998956 Disease Relevance 0.69 Pain Relevance 0.16
On histology, there was increased vasodilatation, marked infiltration with neutrophils and monocytes/macrophages, and increased expression of beta 2 integrins in lesional vs. normal skin.
Positive_regulation (increased) of Gene_expression (expression) of beta 2 in macrophages
5) Confidence 0.49 Published 2004 Journal Br. J. Dermatol. Section Body Doc Link 15270877 Disease Relevance 0 Pain Relevance 0
An increased expression of PLC-beta3 and PKC-alpha and -beta2 was also evidentiated at the longer time points explored, when the effects of ATRA in preservation of the differentiated morphology were maximal.
Positive_regulation (increased) of Gene_expression (expression) of beta2
6) Confidence 0.49 Published 2003 Journal Int J Artif Organs Section Abstract Doc Link 12866655 Disease Relevance 0.08 Pain Relevance 0.09
However, cotransfection with either TR beta 1 or TR beta 2 expression plasmids produced no effect on the ER alpha or ER beta mediated induction of PPE.
Positive_regulation (cotransfection) of Gene_expression (cotransfection) of beta 2
7) Confidence 0.49 Published 2001 Journal J. Neuroendocrinol. Section Abstract Doc Link 11578528 Disease Relevance 0.08 Pain Relevance 0
Using specific antibodies for immunohistochemistry, we have now detected sodium channel beta1 and beta2 subunits in sensory cell bodies within control human postmortem sensory ganglia (78% of small/medium (< or = 50 microm) and 68% of large (> or = 50 microm) cells); their changes in cervical sensory ganglia after avulsion injury paralleled those described for SNS/PN3 alpha-subunits.
Positive_regulation (detected) of Gene_expression (detected) of beta2 in ganglia associated with injury and sodium channel
8) Confidence 0.49 Published 2001 Journal Neuroreport Section Abstract Doc Link 11234750 Disease Relevance 0.28 Pain Relevance 0.34
At the transfected human alpha 4 beta 2 neuronal nAChR (K177 cells), with increased 86Rb+ efflux as a measure of cation efflux, ABT-594 had an EC50 value of 140 nM with an intrinsic activity (IA) compared with (-)-nicotine of 130%; at the nAChR subtype expressed in IMR-32 cells (sympathetic ganglion-like), an EC50 of 340 nM (IA = 126%); at the F11 dorsal root ganglion cell line (sensory ganglion-like), an EC50 of 1220 nM (IA = 71%); and via direct measurement of ion currents, an EC50 value of 56,000 nM (IA = 83%) at the human alpha 7 homooligimeric nAChR produced in oocytes.
Positive_regulation (transfected) of Gene_expression (transfected) of beta 2 in IMR-32 associated with ganglion cysts, dorsal root ganglion and nicotine
9) Confidence 0.45 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9580626 Disease Relevance 0.26 Pain Relevance 0.22
On histology, there was increased vasodilatation, marked infiltration with neutrophils and monocytes/macrophages, and increased expression of beta 2 integrins in lesional vs. normal skin.
Positive_regulation (increased) of in neutrophils Gene_expression (expression) of beta 2 in macrophages
10) Confidence 0.23 Published 2004 Journal Br. J. Dermatol. Section Body Doc Link 15270877 Disease Relevance 0 Pain Relevance 0
On histology, there was increased vasodilatation, marked infiltration with neutrophils and monocytes/macrophages, and increased expression of beta 2 integrins in lesional vs. normal skin.
Positive_regulation (increased) of in monocytes Gene_expression (expression) of beta 2 in macrophages
11) Confidence 0.23 Published 2004 Journal Br. J. Dermatol. Section Body Doc Link 15270877 Disease Relevance 0 Pain Relevance 0
On histology, there was increased vasodilatation, marked infiltration with neutrophils and monocytes/macrophages, and increased expression of beta 2 integrins in lesional vs. normal skin.
Positive_regulation (increased) of in neutrophils Gene_expression (expression) of beta 2 in macrophages
12) Confidence 0.17 Published 2004 Journal Br. J. Dermatol. Section Body Doc Link 15270877 Disease Relevance 0 Pain Relevance 0
On histology, there was increased vasodilatation, marked infiltration with neutrophils and monocytes/macrophages, and increased expression of beta 2 integrins in lesional vs. normal skin.
Positive_regulation (increased) of in monocytes Gene_expression (expression) of beta 2 in macrophages
13) Confidence 0.17 Published 2004 Journal Br. J. Dermatol. Section Body Doc Link 15270877 Disease Relevance 0 Pain Relevance 0

General Comments

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