INT189734

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Context Info
Confidence 0.24
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 1.84
Pain Relevance 0.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (TERT) DNA binding (TERT) cytoplasm (TERT)
RNA binding (TERT) chromosome (TERT) nucleolus (TERT)
Anatomy Link Frequency
somatic cells 4
TERT (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 28 99.46 Very High Very High Very High
cINOD 7 98.76 Very High Very High Very High
Kinase C 329 94.96 High High
Inflammation 102 54.08 Quite High
cytokine 54 20.04 Low Low
chemokine 8 5.00 Very Low Very Low Very Low
Central nervous system 7 5.00 Very Low Very Low Very Low
fibrosis 6 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
Inflammatory mediators 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 28 100.00 Very High Very High Very High
INFLAMMATION 115 98.52 Very High Very High Very High
Cancer 168 98.12 Very High Very High Very High
Cervical Cancer 7 88.48 High High
Apoptosis 25 86.08 High High
Reprotox - General 1 14 81.20 Quite High
Increased Venous Pressure Under Development 7 79.64 Quite High
Aging 34 79.48 Quite High
Keloid Scars 206 67.68 Quite High
Colon Cancer 7 55.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This deficient expression of hTERT and telomerase in PBMCs possibly represents a tumor suppressor mechanism, essential for the protection of these cells against the development of cancer.
Negative_regulation (deficient) of Gene_expression (expression) of hTERT associated with cancer
1) Confidence 0.24 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.49 Pain Relevance 0.03
The Receptor Ck dependent down-regulation of hTERT transcription observed in normal human PBMCs may reflect a general mechanism for the repression of hTERT and telomerase expression in normal somatic cells.
Negative_regulation (repression) of Gene_expression (expression) of hTERT in somatic cells associated with repression
2) Confidence 0.24 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.18 Pain Relevance 0.17
Activated Receptor Ck was found to down-regulate hTERT mRNA expression by repressing the transcription of c-myc gene.
Negative_regulation (down) of Gene_expression (expression) of hTERT mRNA
3) Confidence 0.18 Published 2006 Journal BMC Cell Biol Section Abstract Doc Link PMC1351175 Disease Relevance 0.09 Pain Relevance 0.10
by its agonist pioglitazone was found to down-regulate the mRNA expression of c-myc and hTERT genes in PBMCs (Figure 6).
Negative_regulation (down) of Gene_expression (expression) of hTERT associated with agonist
4) Confidence 0.18 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.14 Pain Relevance 0.43
All these molecules may repress hTERT gene expression and thereby, telomerase activity through PPAR?
Negative_regulation (repress) of Gene_expression (expression) of hTERT
5) Confidence 0.18 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.42 Pain Relevance 0.10
A similar decrease was observed in hTERT mRNA expression (Figure 4), thus proving that Receptor Ck regulates hTERT gene transcription indirectly by controlling the transcription of c-myc gene.
Negative_regulation (observed) of Gene_expression (expression) of hTERT mRNA
6) Confidence 0.17 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0 Pain Relevance 0
While the expression of hTERT is repressed in normal somatic cells (telomerase negative) and is upregulated in immortal cells (telomerase positive), the other components of telomerase holoenzyme are usually expressed ubiquitously in both telomerase positive and telomerase negative cells [7].
Negative_regulation (repressed) of Gene_expression (expression) of hTERT in somatic cells
7) Confidence 0.17 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.22 Pain Relevance 0
Our results indicated that IL-17-induced hTERT and Oct-4 expression was abolished by pretreatment with neutralizing antibody for either IL-17, or IL-6, or both (Figure 5D).
Negative_regulation (abolished) of Gene_expression (expression) of hTERT
8) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2771422 Disease Relevance 0.07 Pain Relevance 0
Our data showed that treatment with IL-6 neutralizing antibodies suppressed hTERT expression in both KPCs and SKPs (Figures 4G and 4H) in a dose-dependent manner.
Negative_regulation (suppressed) of Gene_expression (expression) of hTERT
9) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2771422 Disease Relevance 0.23 Pain Relevance 0.03

General Comments

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