INT189736

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.40
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 22
Total Number 22
Disease Relevance 3.58
Pain Relevance 1.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (TERT) DNA binding (TERT) cytoplasm (TERT)
RNA binding (TERT) chromosome (TERT) nucleolus (TERT)
Anatomy Link Frequency
liver 2
TERT (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 752 98.40 Very High Very High Very High
cINOD 17 82.48 Quite High
agonist 64 74.08 Quite High
Central nervous system 16 24.96 Low Low
Paracetamol 3 11.52 Low Low
Inflammation 12 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
analgesia 2 5.00 Very Low Very Low Very Low
Bile 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Skin Cancer 1 99.50 Very High Very High Very High
Fistula 3 95.48 Very High Very High Very High
Reprotox - General 1 38 95.08 Very High Very High Very High
Apoptosis 58 93.44 High High
Repression 64 93.20 High High
Cancer 260 92.92 High High
Hepatitis 52 88.24 High High
Papillomavirus Infection 16 87.68 High High
INFLAMMATION 28 82.24 Quite High
Targeted Disruption 36 75.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, since the sequence of the porcine TERT promoter has not been reported and therefore differences in the molecular regulation of TERT between human and porcine hepatocytes cannot be excluded, results have to be confirmed in human liver samples and primary human hepatocyte cultures.
Regulation (regulation) of TERT in liver
1) Confidence 0.40 Published 2007 Journal Comp Hepatol Section Body Doc Link PMC1920532 Disease Relevance 0.13 Pain Relevance 0
Further investigations in animal models, such as introduced in this study, have to be conducted to elucidate the molecular mechanism of TERT regulation in liver regeneration.
Regulation (regulation) of TERT in liver
2) Confidence 0.40 Published 2007 Journal Comp Hepatol Section Body Doc Link PMC1920532 Disease Relevance 0.06 Pain Relevance 0
Two provincial directors suggested that character problems among TCs as well as among medical doctors are important in the existing relationship between the two categories.

"...

Regulation (important) of TCs
3) Confidence 0.39 Published 2007 Journal Hum Resour Health Section Body Doc Link PMC2235883 Disease Relevance 0 Pain Relevance 0
Although various steps at post-transcriptional and post-translational levels have been found to modulate telomerase activity, substantial experimental data have established that the transcriptional control of hTERT gene is the major contributor to the regulation of telomerase activity in most cell types [7].
Regulation (control) of hTERT
4) Confidence 0.25 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.25 Pain Relevance 0
"It is like this, the TCs are very important for the life of our health units: first we don't have specialists to address the country's needs (...) any health unit without a TC suffers a lot due to the lack of this cadre.
Regulation (important) of TCs
5) Confidence 0.24 Published 2007 Journal Hum Resour Health Section Body Doc Link PMC2235883 Disease Relevance 0 Pain Relevance 0
A small group of professionals, mainly specialists, raised concerns regarding practice regulation; they considered that in some instances TCs intervene above their abilities:

"There should be a regulation regarding the interventions that the TCs can perform; some perform surgery above their capacities, for example: fistulas, prostate cancer, etc.

Regulation (regulation) of TCs associated with fistula and reprotox - general 1
6) Confidence 0.24 Published 2007 Journal Hum Resour Health Section Body Doc Link PMC2235883 Disease Relevance 0.19 Pain Relevance 0
Canine squamous cell carcinomas were used as a positive control for TERT, pAkt, ?
Regulation (control) of TERT associated with skin cancer
7) Confidence 0.19 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994344 Disease Relevance 0.17 Pain Relevance 0
There is also evidence to suggest that chromatin remodeling by various transcription factors may be involved in the regulation of hTERT gene transcription [12].
Regulation (regulation) of hTERT
8) Confidence 0.18 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.62 Pain Relevance 0
B) have been found to positively regulate hTERT transcription [7-9].
Regulation (regulate) of hTERT
9) Confidence 0.18 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.13 Pain Relevance 0
The observation that the addition of 25OH-C to PBMCs cultured in medium enriched with 10% NHS is able to disrupt the Receptor Ck dependent down-regulation of hTERT, c-myc and PPAR?
Regulation (regulation) of hTERT
10) Confidence 0.18 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0 Pain Relevance 0
Several studies have implicated sex steroid hormones (estrogen, progesterone and androgens) in the regulation of hTERT transcription [7].
Regulation (regulation) of hTERT
11) Confidence 0.18 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.57 Pain Relevance 0
Available evidence suggests that the regulation of telomerase activity primarily depends on the transcriptional control of the human telomerase reverse transcriptase (hTERT) gene.
Regulation (control) of hTERT
12) Confidence 0.11 Published 2006 Journal BMC Cell Biol Section Abstract Doc Link PMC1351175 Disease Relevance 0.08 Pain Relevance 0
More importantly, the data suggest the possibility that the presence of an oxysterol along with LDL could influence and alter the transcriptional regulation of hTERT, c-myc and PPAR?
Regulation (regulation) of hTERT
13) Confidence 0.11 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0 Pain Relevance 0.06
Besides implicating cholesterol (through Receptor Ck) in the transcriptional regulation of hTERT gene, the present study reveals the involvement of oxysterols, the oxygenated derivatives of cholesterol, in the regulation of hTERT gene transcription.
Regulation (regulation) of hTERT
14) Confidence 0.11 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.41 Pain Relevance 0.08
The treatment of cells with PMA (PKC activator) was found to abolish the Receptor Ck dependent transcriptional down-regulation of hTERT, PPAR?
Regulation (regulation) of hTERT associated with kinase c
15) Confidence 0.11 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.17 Pain Relevance 0.32
Addition of 25OH-C transiently abolished the Receptor Ck dependent transcriptional down-regulation of hTERT, c-myc and PPAR?
Regulation (regulation) of hTERT
16) Confidence 0.11 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0 Pain Relevance 0
In addition, 25-hydroxycholesterol was found to contribute to the transcriptional regulation of hTERT gene.


Regulation (regulation) of hTERT
17) Confidence 0.11 Published 2006 Journal BMC Cell Biol Section Abstract Doc Link PMC1351175 Disease Relevance 0.06 Pain Relevance 0.14
Hence, the cholesterol specific Receptor Ck and not LDLR was responsible for the transcriptional regulation of hTERT, c-myc and PPAR?
Regulation (regulation) of hTERT
18) Confidence 0.11 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.06 Pain Relevance 0
The observation that PKC activation by PMA is able to reverse the Receptor Ck dependent transcriptional down-regulation of hTERT, c-myc and PPAR?
Regulation (regulation) of hTERT associated with kinase c
19) Confidence 0.11 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0 Pain Relevance 0.39
and oxysterol (25OH-C) in the transcriptional regulation of hTERT gene.
Regulation (regulation) of hTERT
20) Confidence 0.11 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0 Pain Relevance 0.30

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox