INT189748

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Context Info
Confidence 0.36
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 1.60
Pain Relevance 1.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (CHKB)
Anatomy Link Frequency
mononuclear cells 1
CHKB (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 235 99.08 Very High Very High Very High
abdominal pain 2 84.24 Quite High
agonist 20 21.36 Low Low
Central nervous system 5 5.00 Very Low Very Low Very Low
cINOD 5 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
pain pelvic 2 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
methotrexate 1 5.00 Very Low Very Low Very Low
endometriosis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ectopic Pregnancy 95 99.80 Very High Very High Very High
Cancer 81 98.36 Very High Very High Very High
Repression 20 95.08 Very High Very High Very High
Rupture 3 92.16 High High
Abdominal Pain 2 84.24 Quite High
Reprotox - General 1 24 83.36 Quite High
Ovarian Cancer 1 74.56 Quite High
Tubal Pregnancy 10 72.56 Quite High
Threatened Abortion 1 70.04 Quite High
Targeted Disruption 10 44.52 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The authors stated that the serum CK level was statistically higher in EP patients than in controls, but the CK value distribution curve for EP was broad and overlapped with the control curve, indicating that the sensitivity and positive predictive value of this test were poor.44

CA 125

Transcription (curve) of CK associated with ectopic pregnancy
1) Confidence 0.36 Published 2008 Journal Clinics Section Body Doc Link PMC2664731 Disease Relevance 1.19 Pain Relevance 0.08
The observation that PKC activation by PMA is able to reverse the Receptor Ck dependent transcriptional down-regulation of hTERT, c-myc and PPAR?
Transcription (transcriptional) of Ck associated with kinase c
2) Confidence 0.33 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0 Pain Relevance 0.41
Addition of 25OH-C transiently abolished the Receptor Ck dependent transcriptional down-regulation of hTERT, c-myc and PPAR?
Transcription (transcriptional) of Ck
3) Confidence 0.33 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0 Pain Relevance 0
It is attractive to suggest that the failure of this Receptor Ck dependent repressive mechanism may contribute to upregulation of hTERT transcription and induction of telomerase activity in cancer cells.
Transcription (transcription) of Ck associated with cancer
4) Confidence 0.33 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.19 Pain Relevance 0.15
The treatment of cells with PMA (PKC activator) was found to abolish the Receptor Ck dependent transcriptional down-regulation of hTERT, PPAR?
Transcription (transcriptional) of Ck associated with kinase c
5) Confidence 0.33 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.17 Pain Relevance 0.29
Taken together, the findings of this study present evidence for a molecular link between cholesterol-activated Receptor Ck and hTERT transcription, and provide new insights into the regulation of hTERT expression in normal human peripheral blood mononuclear cells.



Transcription (transcription) of Ck in mononuclear cells
6) Confidence 0.25 Published 2006 Journal BMC Cell Biol Section Abstract Doc Link PMC1351175 Disease Relevance 0.05 Pain Relevance 0.13

General Comments

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