INT189748
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
The authors stated that the serum CK level was statistically higher in EP patients than in controls, but the CK value distribution curve for EP was broad and overlapped with the control curve, indicating that the sensitivity and positive predictive value of this test were poor.44
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The observation that PKC activation by PMA is able to reverse the Receptor Ck dependent transcriptional down-regulation of hTERT, c-myc and PPAR? | |||||||||||||||
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Addition of 25OH-C transiently abolished the Receptor Ck dependent transcriptional down-regulation of hTERT, c-myc and PPAR? | |||||||||||||||
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It is attractive to suggest that the failure of this Receptor Ck dependent repressive mechanism may contribute to upregulation of hTERT transcription and induction of telomerase activity in cancer cells. | |||||||||||||||
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The treatment of cells with PMA (PKC activator) was found to abolish the Receptor Ck dependent transcriptional down-regulation of hTERT, PPAR? | |||||||||||||||
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Taken together, the findings of this study present evidence for a molecular link between cholesterol-activated Receptor Ck and hTERT transcription, and provide new insights into the regulation of hTERT expression in normal human peripheral blood mononuclear cells.
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General Comments
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