INT189748

Context Info Confidence 0.36 First Reported 2006 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 6 Total Number 6 Disease Relevance 1.60 Pain Relevance 1.07

cytoplasm (CHKB)

Anatomy Link Frequency mononuclear cells 1 CHKB (Homo sapiens)

Pain Link Frequency Relevance Heat Kinase C 235 99.08 abdominal pain 2 84.24 agonist 20 21.36 Central nervous system 5 5.00 cINOD 5 5.00 Inflammation 2 5.00 pain pelvic 2 5.00 cytokine 1 5.00 methotrexate 1 5.00 endometriosis 1 5.00

Disease Link Frequency Relevance Heat Ectopic Pregnancy 95 99.80 Cancer 81 98.36 Repression 20 95.08 Rupture 3 92.16 Abdominal Pain 2 84.24 Reprotox - General 1 24 83.36 Ovarian Cancer 1 74.56 Tubal Pregnancy 10 72.56 Threatened Abortion 1 70.04 Targeted Disruption 10 44.52

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The authors stated that the serum CK level was statistically higher in EP patients than in controls, but the CK value distribution curve for EP was broad and overlapped with the control curve, indicating that the sensitivity and positive predictive value of this test were poor.44 CA 125

Transcription (curve) of CK associated with ectopic pregnancy

1) Confidence 0.36 Published 2008 Journal Clinics Section Body Doc Link PMC2664731 Disease Relevance 1.19 Pain Relevance 0.08

The observation that PKC activation by PMA is able to reverse the Receptor Ck dependent transcriptional down-regulation of hTERT, c-myc and PPAR?

Transcription (transcriptional) of Ck associated with kinase c

2) Confidence 0.33 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0 Pain Relevance 0.41

Addition of 25OH-C transiently abolished the Receptor Ck dependent transcriptional down-regulation of hTERT, c-myc and PPAR?

Transcription (transcriptional) of Ck

3) Confidence 0.33 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0 Pain Relevance 0

It is attractive to suggest that the failure of this Receptor Ck dependent repressive mechanism may contribute to upregulation of hTERT transcription and induction of telomerase activity in cancer cells.

Transcription (transcription) of Ck associated with cancer

4) Confidence 0.33 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.19 Pain Relevance 0.15

The treatment of cells with PMA (PKC activator) was found to abolish the Receptor Ck dependent transcriptional down-regulation of hTERT, PPAR?

Transcription (transcriptional) of Ck associated with kinase c

5) Confidence 0.33 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.17 Pain Relevance 0.29

Taken together, the findings of this study present evidence for a molecular link between cholesterol-activated Receptor Ck and hTERT transcription, and provide new insights into the regulation of hTERT expression in normal human peripheral blood mononuclear cells.

Transcription (transcription) of Ck in mononuclear cells

6) Confidence 0.25 Published 2006 Journal BMC Cell Biol Section Abstract Doc Link PMC1351175 Disease Relevance 0.05 Pain Relevance 0.13

General Comments

This test has worked.