INT189752

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Context Info
Confidence 0.09
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 1.89
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CCND3) nucleus (CCND3) cell division (CCND3)
cytoplasm (CCND3)
Anatomy Link Frequency
mammary glands 2
CCND3 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 4 17.64 Low Low
Kinase C 47 5.00 Very Low Very Low Very Low
addiction 15 5.00 Very Low Very Low Very Low
Inflammation 5 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 16 98.80 Very High Very High Very High
Breast Cancer 126 98.74 Very High Very High Very High
Prostate Cancer 81 98.08 Very High Very High Very High
Glioma 26 92.24 High High
Apoptosis 17 91.48 High High
Hyperplasia 3 83.56 Quite High
Aging 9 83.24 Quite High
Colon Cancer 3 62.16 Quite High
Metastasis 15 54.92 Quite High
Recurrence 9 54.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Indeed, MMTV-cyclin D2 mice show increased proliferation of mammary glands in pregnant females, but alveolar differentiation is partially or completely inhibited.157 In one report, cyclin D3 was overexpressed in breast cancers, but there are limited data on its relationship to the phenotype of breast cancer and prognosis of patients.158 Keyomarsi et al showed that the absence of cyclin D1 or cyclin D3 protein expression was associated with improved disease-specific and overall survival, but the correlations were less striking than those for cyclin E.159

Cyclin E

Negative_regulation (absence) of Gene_expression (expression) of cyclin D3 in mammary glands associated with breast cancer and disease
1) Confidence 0.09 Published 2010 Journal Clinical Medicine Insights. Oncology Section Body Doc Link PMC2883240 Disease Relevance 0.68 Pain Relevance 0
Determination of cyclin D and Bcl-2 expression by western blotting
Negative_regulation (Determination) of Gene_expression (expression) of cyclin D
2) Confidence 0.08 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0 Pain Relevance 0
Our robustness analysis identified eIF4E as a limiting reagent in the expression of both cyclin D and PSA in C-81 clones.
Negative_regulation (limiting) of Gene_expression (expression) of cyclin D
3) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0.33 Pain Relevance 0
Down-regulation of eIF4E resulted in decreased cyclin D expression and decreased growth rate without the deleterious effect of inhibitors such as rapamycin which act further upstream [68].
Negative_regulation (decreased) of Gene_expression (expression) of cyclin D
4) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0.26 Pain Relevance 0
While the expression of cPAcP in C-81 reduced cyclin D levels (Fig. 5C, lane 2), sPAcP expression resulted in no change (Fig. 5C, lane 3).
Negative_regulation (reduced) of Gene_expression (levels) of cyclin D
5) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0 Pain Relevance 0
In the present study, we show that the co-depletion of cathepsin B and uPAR arrests cells in the G1 phase primarily through the upregulation of p27Kip1 and that this pathway involves the downregulation of p-PI3K, p-AKT, D-type cyclin expression, and cyclin E/Cdk2 complex formation as well as the subsequent upregulation of the FOXO3a protein and its nuclear localization.
Negative_regulation (downregulation) of Gene_expression (expression) of D-type cyclin
6) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.62 Pain Relevance 0

General Comments

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