INT189755

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Context Info
Confidence 0.65
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 42
Total Number 42
Disease Relevance 10.88
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CCND3) nucleus (CCND3) cell division (CCND3)
cytoplasm (CCND3)
Anatomy Link Frequency
mammary glands 2
CCND3 (Homo sapiens)
Pain Link Frequency Relevance Heat
addiction 155 85.12 High High
Central nervous system 4 73.44 Quite High
Kinase C 191 69.36 Quite High
cINOD 7 68.00 Quite High
aspirin 7 59.92 Quite High
Pain 31 57.52 Quite High
imagery 1 21.08 Low Low
agonist 16 16.96 Low Low
antagonist 35 15.44 Low Low
Inflammation 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 277 99.84 Very High Very High Very High
Targeted Disruption 401 99.62 Very High Very High Very High
Disease 57 98.80 Very High Very High Very High
Prostate Cancer 837 98.16 Very High Very High Very High
Lung Cancer 32 97.92 Very High Very High Very High
Cervical Cancer 27 94.24 High High
Glioma 26 90.92 High High
Aging 26 90.84 High High
Apoptosis 42 90.16 High High
Repression 19 88.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CUG-BP1 was also phosphorylated at Ser302 by cyclinD3/cdk4 complexes.
Gene_expression (complexes) of cyclinD3
1) Confidence 0.65 Published 2008 Journal Current Genomics Section Body Doc Link PMC2694559 Disease Relevance 0 Pain Relevance 0
In previous reports 28, 29 protein expression of p27, p21, p16, cyclin A, cyclin E and cyclin D3 were studied with immunohistochemistry in the same patient populations.
Gene_expression (expression) of cyclin D3
2) Confidence 0.32 Published 2008 Journal International Journal of Medical Sciences Section Body Doc Link PMC2424178 Disease Relevance 0.32 Pain Relevance 0
Determination of cyclin D and Bcl-2 expression by western blotting
Gene_expression (expression) of cyclin D
3) Confidence 0.15 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0 Pain Relevance 0
Indeed, MMTV-cyclin D2 mice show increased proliferation of mammary glands in pregnant females, but alveolar differentiation is partially or completely inhibited.157 In one report, cyclin D3 was overexpressed in breast cancers, but there are limited data on its relationship to the phenotype of breast cancer and prognosis of patients.158 Keyomarsi et al showed that the absence of cyclin D1 or cyclin D3 protein expression was associated with improved disease-specific and overall survival, but the correlations were less striking than those for cyclin E.159

Cyclin E

Gene_expression (overexpressed) of cyclin D3 in mammary glands associated with breast cancer and disease
4) Confidence 0.12 Published 2010 Journal Clinical Medicine Insights. Oncology Section Body Doc Link PMC2883240 Disease Relevance 0.77 Pain Relevance 0
Indeed, MMTV-cyclin D2 mice show increased proliferation of mammary glands in pregnant females, but alveolar differentiation is partially or completely inhibited.157 In one report, cyclin D3 was overexpressed in breast cancers, but there are limited data on its relationship to the phenotype of breast cancer and prognosis of patients.158 Keyomarsi et al showed that the absence of cyclin D1 or cyclin D3 protein expression was associated with improved disease-specific and overall survival, but the correlations were less striking than those for cyclin E.159

Cyclin E

Gene_expression (expression) of cyclin D3 in mammary glands associated with breast cancer and disease
5) Confidence 0.12 Published 2010 Journal Clinical Medicine Insights. Oncology Section Body Doc Link PMC2883240 Disease Relevance 0.68 Pain Relevance 0
Receptor Ck has been shown to initiate a signaling pathway that controls the expression of several genes involved in cell cycle, such as, the genes encoding cyclin D, Bcl-2, p27, c-myc and c-fos [14].
Gene_expression (expression) of cyclin D
6) Confidence 0.12 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.41 Pain Relevance 0.04
However, on comparing the expression pattern of cyclin D and Bcl-2 proteins (Figure 3C) with the hTERT mRNA expression in human normal PBMCs exposed to growth medium containing 10% NHS and 2.5 mM EGTA (Figure 3B), no correlation was found between cyclin D expression and hTERT transcription or between Bcl-2 expression and hTERT transcription.
Gene_expression (expression) of cyclin D
7) Confidence 0.12 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0 Pain Relevance 0
However, on comparing the expression pattern of cyclin D and Bcl-2 proteins (Figure 3C) with the hTERT mRNA expression in human normal PBMCs exposed to growth medium containing 10% NHS and 2.5 mM EGTA (Figure 3B), no correlation was found between cyclin D expression and hTERT transcription or between Bcl-2 expression and hTERT transcription.
Gene_expression (expression) of cyclin D
8) Confidence 0.12 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0 Pain Relevance 0
Furthermore, the translation initiation factor eIF4E demonstrated a limiting reagent behavior in the expression of both cyclin D and PSA while perturbations in 4E-BP1 had little effect (Fig 8, lanes 6 and 7).
Gene_expression (expression) of cyclin D
9) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0.60 Pain Relevance 0
We compared the steady-state cyclin D expression in Akt and ERK knock-outs with wild-type C-81 cells in the absence of androgens.
Gene_expression (expression) of cyclin D associated with targeted disruption
10) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0.32 Pain Relevance 0
Nominally, C-33 cells have lower cyclin D expression compared to C-81 (Fig. 5C, lane 1 and 4).
Gene_expression (expression) of cyclin D
11) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0 Pain Relevance 0
Cyclin D is expressed early in the cell cycle and a point of convergence in the proliferative action of multiple receptors [70].
Gene_expression (expressed) of Cyclin D
12) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0.30 Pain Relevance 0
Cyclin D expression was coupled to ERK through the ETS and AP1 transcription factors, both of which activate cyclin D expression [59].
Gene_expression (expression) of Cyclin D
13) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0 Pain Relevance 0
However, the relatively large standard deviation suggested that cyclin D expression varied widely across the ensemble.
Gene_expression (expression) of cyclin D
14) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0.19 Pain Relevance 0
We constrained Her2 induced MAPK activation using cyclin D protein expression data in C-33 and C-81 cells without androgen following PAcP expression (Fig. 5C).
Gene_expression (expression) of cyclin D
15) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0 Pain Relevance 0
Analysis of the ensemble of AI models suggested the Akt and MAPK pathways synergistically enhanced cyclin D expression by up-regulating translation.
Gene_expression (expression) of cyclin D
16) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0.29 Pain Relevance 0
At steady-state, the MAPK and Akt pathways synergistically () activated cyclin D expression in C-81 cells without androgen (Fig. 9A).
Gene_expression (expression) of cyclin D
17) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0.30 Pain Relevance 0
The above-additive (superlinear) cyclin D expression was statistically significant within a 95% confidence interval.
Gene_expression (expression) of cyclin D
18) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0.21 Pain Relevance 0
Cyclin D expression was coupled to ERK through the ETS and AP1 transcription factors, both of which activate cyclin D expression [59].
Gene_expression (expression) of cyclin D
19) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0 Pain Relevance 0
Constitutive and regulated expression of PSA, cyclin D and the two forms of PAcP were considered in the model.
Gene_expression (expression) of cyclin D
20) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0.13 Pain Relevance 0.06

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