INT189755
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
CUG-BP1 was also phosphorylated at Ser302 by cyclinD3/cdk4 complexes. | |||||||||||||||
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In previous reports 28, 29 protein expression of p27, p21, p16, cyclin A, cyclin E and cyclin D3 were studied with immunohistochemistry in the same patient populations. | |||||||||||||||
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Determination of cyclin D and Bcl-2 expression by western blotting | |||||||||||||||
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Indeed, MMTV-cyclin D2 mice show increased proliferation of mammary glands in pregnant females, but alveolar differentiation is partially or completely inhibited.157 In one report, cyclin D3 was overexpressed in breast cancers, but there are limited data on its relationship to the phenotype of breast cancer and prognosis of patients.158 Keyomarsi et al showed that the absence of cyclin D1 or cyclin D3 protein expression was associated with improved disease-specific and overall survival, but the correlations were less striking than those for cyclin E.159
Cyclin E | |||||||||||||||
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Indeed, MMTV-cyclin D2 mice show increased proliferation of mammary glands in pregnant females, but alveolar differentiation is partially or completely inhibited.157 In one report, cyclin D3 was overexpressed in breast cancers, but there are limited data on its relationship to the phenotype of breast cancer and prognosis of patients.158 Keyomarsi et al showed that the absence of cyclin D1 or cyclin D3 protein expression was associated with improved disease-specific and overall survival, but the correlations were less striking than those for cyclin E.159
Cyclin E | |||||||||||||||
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Receptor Ck has been shown to initiate a signaling pathway that controls the expression of several genes involved in cell cycle, such as, the genes encoding cyclin D, Bcl-2, p27, c-myc and c-fos [14]. | |||||||||||||||
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However, on comparing the expression pattern of cyclin D and Bcl-2 proteins (Figure 3C) with the hTERT mRNA expression in human normal PBMCs exposed to growth medium containing 10% NHS and 2.5 mM EGTA (Figure 3B), no correlation was found between cyclin D expression and hTERT transcription or between Bcl-2 expression and hTERT transcription. | |||||||||||||||
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However, on comparing the expression pattern of cyclin D and Bcl-2 proteins (Figure 3C) with the hTERT mRNA expression in human normal PBMCs exposed to growth medium containing 10% NHS and 2.5 mM EGTA (Figure 3B), no correlation was found between cyclin D expression and hTERT transcription or between Bcl-2 expression and hTERT transcription. | |||||||||||||||
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Furthermore, the translation initiation factor eIF4E demonstrated a limiting reagent behavior in the expression of both cyclin D and PSA while perturbations in 4E-BP1 had little effect (Fig 8, lanes 6 and 7). | |||||||||||||||
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We compared the steady-state cyclin D expression in Akt and ERK knock-outs with wild-type C-81 cells in the absence of androgens. | |||||||||||||||
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Nominally, C-33 cells have lower cyclin D expression compared to C-81 (Fig. 5C, lane 1 and 4). | |||||||||||||||
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Cyclin D is expressed early in the cell cycle and a point of convergence in the proliferative action of multiple receptors [70]. | |||||||||||||||
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Cyclin D expression was coupled to ERK through the ETS and AP1 transcription factors, both of which activate cyclin D expression [59]. | |||||||||||||||
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However, the relatively large standard deviation suggested that cyclin D expression varied widely across the ensemble. | |||||||||||||||
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We constrained Her2 induced MAPK activation using cyclin D protein expression data in C-33 and C-81 cells without androgen following PAcP expression (Fig. 5C). | |||||||||||||||
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Analysis of the ensemble of AI models suggested the Akt and MAPK pathways synergistically enhanced cyclin D expression by up-regulating translation. | |||||||||||||||
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At steady-state, the MAPK and Akt pathways synergistically () activated cyclin D expression in C-81 cells without androgen (Fig. 9A). | |||||||||||||||
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The above-additive (superlinear) cyclin D expression was statistically significant within a 95% confidence interval. | |||||||||||||||
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Cyclin D expression was coupled to ERK through the ETS and AP1 transcription factors, both of which activate cyclin D expression [59]. | |||||||||||||||
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Constitutive and regulated expression of PSA, cyclin D and the two forms of PAcP were considered in the model. | |||||||||||||||
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