INT189755

Context Info Confidence 0.65 First Reported 2006 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 42 Total Number 42 Disease Relevance 10.88 Pain Relevance 0.39

signal transduction (CCND3) nucleus (CCND3) cell division (CCND3) cytoplasm (CCND3)

Anatomy Link Frequency mammary glands 2 CCND3 (Homo sapiens)

Pain Link Frequency Relevance Heat addiction 155 85.12 Central nervous system 4 73.44 Kinase C 191 69.36 cINOD 7 68.00 aspirin 7 59.92 Pain 31 57.52 imagery 1 21.08 agonist 16 16.96 antagonist 35 15.44 Inflammation 11 5.00

Disease Link Frequency Relevance Heat Breast Cancer 277 99.84 Targeted Disruption 401 99.62 Disease 57 98.80 Prostate Cancer 837 98.16 Lung Cancer 32 97.92 Cervical Cancer 27 94.24 Glioma 26 90.92 Aging 26 90.84 Apoptosis 42 90.16 Repression 19 88.40

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

CUG-BP1 was also phosphorylated at Ser302 by cyclinD3/cdk4 complexes.

Gene_expression (complexes) of cyclinD3

1) Confidence 0.65 Published 2008 Journal Current Genomics Section Body Doc Link PMC2694559 Disease Relevance 0 Pain Relevance 0

In previous reports 28, 29 protein expression of p27, p21, p16, cyclin A, cyclin E and cyclin D3 were studied with immunohistochemistry in the same patient populations.

Gene_expression (expression) of cyclin D3

2) Confidence 0.32 Published 2008 Journal International Journal of Medical Sciences Section Body Doc Link PMC2424178 Disease Relevance 0.32 Pain Relevance 0

Determination of cyclin D and Bcl-2 expression by western blotting

Gene_expression (expression) of cyclin D

3) Confidence 0.15 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0 Pain Relevance 0

Indeed, MMTV-cyclin D2 mice show increased proliferation of mammary glands in pregnant females, but alveolar differentiation is partially or completely inhibited.157 In one report, cyclin D3 was overexpressed in breast cancers, but there are limited data on its relationship to the phenotype of breast cancer and prognosis of patients.158 Keyomarsi et al showed that the absence of cyclin D1 or cyclin D3 protein expression was associated with improved disease-specific and overall survival, but the correlations were less striking than those for cyclin E.159 Cyclin E

Gene_expression (overexpressed) of cyclin D3 in mammary glands associated with breast cancer and disease

4) Confidence 0.12 Published 2010 Journal Clinical Medicine Insights. Oncology Section Body Doc Link PMC2883240 Disease Relevance 0.77 Pain Relevance 0

Indeed, MMTV-cyclin D2 mice show increased proliferation of mammary glands in pregnant females, but alveolar differentiation is partially or completely inhibited.157 In one report, cyclin D3 was overexpressed in breast cancers, but there are limited data on its relationship to the phenotype of breast cancer and prognosis of patients.158 Keyomarsi et al showed that the absence of cyclin D1 or cyclin D3 protein expression was associated with improved disease-specific and overall survival, but the correlations were less striking than those for cyclin E.159 Cyclin E

Gene_expression (expression) of cyclin D3 in mammary glands associated with breast cancer and disease

5) Confidence 0.12 Published 2010 Journal Clinical Medicine Insights. Oncology Section Body Doc Link PMC2883240 Disease Relevance 0.68 Pain Relevance 0

Receptor Ck has been shown to initiate a signaling pathway that controls the expression of several genes involved in cell cycle, such as, the genes encoding cyclin D, Bcl-2, p27, c-myc and c-fos [14].

Gene_expression (expression) of cyclin D

6) Confidence 0.12 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.41 Pain Relevance 0.04

However, on comparing the expression pattern of cyclin D and Bcl-2 proteins (Figure 3C) with the hTERT mRNA expression in human normal PBMCs exposed to growth medium containing 10% NHS and 2.5 mM EGTA (Figure 3B), no correlation was found between cyclin D expression and hTERT transcription or between Bcl-2 expression and hTERT transcription.

Gene_expression (expression) of cyclin D

7) Confidence 0.12 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0 Pain Relevance 0

However, on comparing the expression pattern of cyclin D and Bcl-2 proteins (Figure 3C) with the hTERT mRNA expression in human normal PBMCs exposed to growth medium containing 10% NHS and 2.5 mM EGTA (Figure 3B), no correlation was found between cyclin D expression and hTERT transcription or between Bcl-2 expression and hTERT transcription.

Gene_expression (expression) of cyclin D

8) Confidence 0.12 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0 Pain Relevance 0

Furthermore, the translation initiation factor eIF4E demonstrated a limiting reagent behavior in the expression of both cyclin D and PSA while perturbations in 4E-BP1 had little effect (Fig 8, lanes 6 and 7).

Gene_expression (expression) of cyclin D

9) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0.60 Pain Relevance 0

We compared the steady-state cyclin D expression in Akt and ERK knock-outs with wild-type C-81 cells in the absence of androgens.

Gene_expression (expression) of cyclin D associated with targeted disruption

10) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0.32 Pain Relevance 0

Nominally, C-33 cells have lower cyclin D expression compared to C-81 (Fig. 5C, lane 1 and 4).

Gene_expression (expression) of cyclin D

11) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0 Pain Relevance 0

Cyclin D is expressed early in the cell cycle and a point of convergence in the proliferative action of multiple receptors [70].

Gene_expression (expressed) of Cyclin D

12) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0.30 Pain Relevance 0

Cyclin D expression was coupled to ERK through the ETS and AP1 transcription factors, both of which activate cyclin D expression [59].

Gene_expression (expression) of Cyclin D

13) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0 Pain Relevance 0

However, the relatively large standard deviation suggested that cyclin D expression varied widely across the ensemble.

Gene_expression (expression) of cyclin D

14) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0.19 Pain Relevance 0

We constrained Her2 induced MAPK activation using cyclin D protein expression data in C-33 and C-81 cells without androgen following PAcP expression (Fig. 5C).

Gene_expression (expression) of cyclin D

15) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0 Pain Relevance 0

Analysis of the ensemble of AI models suggested the Akt and MAPK pathways synergistically enhanced cyclin D expression by up-regulating translation.

Gene_expression (expression) of cyclin D

16) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0.29 Pain Relevance 0

At steady-state, the MAPK and Akt pathways synergistically () activated cyclin D expression in C-81 cells without androgen (Fig. 9A).

Gene_expression (expression) of cyclin D

17) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0.30 Pain Relevance 0

The above-additive (superlinear) cyclin D expression was statistically significant within a 95% confidence interval.

Gene_expression (expression) of cyclin D

18) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0.21 Pain Relevance 0

Cyclin D expression was coupled to ERK through the ETS and AP1 transcription factors, both of which activate cyclin D expression [59].

Gene_expression (expression) of cyclin D

19) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0 Pain Relevance 0

Constitutive and regulated expression of PSA, cyclin D and the two forms of PAcP were considered in the model.

Gene_expression (expression) of cyclin D

20) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0.13 Pain Relevance 0.06

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