INT189757

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Context Info
Confidence 0.05
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.09
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

chromosome (TEP1) RNA binding (TEP1) nucleus (TEP1)
cytoplasm (TEP1)
Anatomy Link Frequency
somatic cells 2
stem cell 2
TEP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 94 93.56 High High
Inflammation 51 89.04 High High
cytokine 27 75.44 Quite High
agonist 8 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
fibrosis 3 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 8 100.00 Very High Very High Very High
Cancer 60 98.72 Very High Very High Very High
Keloid Scars 103 93.44 High High
INFLAMMATION 56 89.04 High High
Increased Venous Pressure Under Development 2 79.64 Quite High
Disease 16 78.20 Quite High
Fibrosis 3 77.84 Quite High
Apoptosis 8 74.08 Quite High
Benign Tumor 17 57.40 Quite High
Malignant Neoplastic Disease 3 55.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The Receptor Ck dependent down-regulation of hTERT transcription observed in normal human PBMCs may reflect a general mechanism for the repression of hTERT and telomerase expression in normal somatic cells.
Negative_regulation (repression) of Gene_expression (expression) of telomerase in somatic cells associated with repression
1) Confidence 0.05 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.18 Pain Relevance 0.17
This deficient expression of hTERT and telomerase in PBMCs possibly represents a tumor suppressor mechanism, essential for the protection of these cells against the development of cancer.
Negative_regulation (deficient) of Gene_expression (expression) of telomerase associated with cancer
2) Confidence 0.05 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.49 Pain Relevance 0.03
Moreover, our results show that IL-6 can significantly stimulate the expression of both Oct-4 and telomerase, two important stem cell function genes, in cultured KPCs and SKPs, and incubation with specific IL-6 neutralizing antibodies suppressed the constitutive expression of telomerase in KPCs.
Negative_regulation (suppressed) of Gene_expression (expression) of telomerase in stem cell
3) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2771422 Disease Relevance 1.42 Pain Relevance 0.28

General Comments

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