INT189764

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Context Info
Confidence 0.24
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.61
Pain Relevance 0.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (CHKB)
Anatomy Link Frequency
mononuclear cells 2
CHKB (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 188 99.08 Very High Very High Very High
agonist 16 5.00 Very Low Very Low Very Low
Central nervous system 4 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 64 98.92 Very High Very High Very High
Repression 16 95.08 Very High Very High Very High
Cervical Cancer 4 25.20 Quite Low
Aging 16 5.00 Very Low Very Low Very Low
Apoptosis 12 5.00 Very Low Very Low Very Low
Reprotox - General 1 8 5.00 Very Low Very Low Very Low
Targeted Disruption 8 5.00 Very Low Very Low Very Low
Hyperplasia 4 5.00 Very Low Very Low Very Low
Genetic Translocation 4 5.00 Very Low Very Low Very Low
Chromosomal Instability 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The treatment of cells with PMA (PKC activator) was found to abolish the Receptor Ck dependent transcriptional down-regulation of hTERT, PPAR?
Positive_regulation (dependent) of Transcription (transcriptional) of Ck associated with kinase c
1) Confidence 0.24 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.17 Pain Relevance 0.29
It is attractive to suggest that the failure of this Receptor Ck dependent repressive mechanism may contribute to upregulation of hTERT transcription and induction of telomerase activity in cancer cells.
Positive_regulation (induction) of Transcription (transcription) of Ck associated with cancer
2) Confidence 0.24 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.19 Pain Relevance 0.18
It is attractive to suggest that the failure of this Receptor Ck dependent repressive mechanism may contribute to upregulation of hTERT transcription and induction of telomerase activity in cancer cells.
Positive_regulation (upregulation) of Transcription (transcription) of Ck associated with cancer
3) Confidence 0.24 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.19 Pain Relevance 0.15
Taken together, the findings of this study present evidence for a molecular link between cholesterol-activated Receptor Ck and hTERT transcription, and provide new insights into the regulation of hTERT expression in normal human peripheral blood mononuclear cells.



Positive_regulation (activated) of Transcription (transcription) of Ck in mononuclear cells
4) Confidence 0.22 Published 2006 Journal BMC Cell Biol Section Abstract Doc Link PMC1351175 Disease Relevance 0.05 Pain Relevance 0.13

General Comments

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