INT189766

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Context Info
Confidence 0.25
First Reported 2006
Last Reported 2006
Negated 0
Speculated 2
Reported most in Body
Documents 1
Total Number 17
Disease Relevance 3.48
Pain Relevance 1.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (TERT) DNA binding (TERT) cytoplasm (TERT)
RNA binding (TERT) chromosome (TERT) nucleolus (TERT)
Anatomy Link Frequency
somatic cells 2
mononuclear cells 2
TERT (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 799 99.80 Very High Very High Very High
agonist 68 99.36 Very High Very High Very High
cINOD 17 77.16 Quite High
Central nervous system 17 60.08 Quite High
Disease Link Frequency Relevance Heat
Repression 68 100.00 Very High Very High Very High
Targeted Disruption 34 96.60 Very High Very High Very High
Cancer 272 96.00 Very High Very High Very High
Cervical Cancer 17 95.36 Very High Very High Very High
Reprotox - General 1 34 89.56 High High
Aging 68 87.40 High High
Apoptosis 51 86.88 High High
Hepatitis 17 80.52 Quite High
Papillomavirus Infection 17 79.96 Quite High
INFLAMMATION 17 76.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
negatively regulates hTERT transcription suggests that deficient expression of PPAR?
Regulation (regulates) of Transcription (transcription) of hTERT
1) Confidence 0.25 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.15 Pain Relevance 0.07
in the regulation of the transcription of c-myc and hTERT genes.
Regulation (regulation) of Transcription (transcription) of hTERT
2) Confidence 0.25 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.16 Pain Relevance 0.12
Hence, it was inferred that cyclin D and Bcl-2 might not play any role in the regulation of hTERT transcription in normal human PBMCs.


Regulation (regulation) of Transcription (transcription) of hTERT
3) Confidence 0.25 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0 Pain Relevance 0
by its agonist pioglitazone was found to down-regulate the mRNA expression of c-myc and hTERT genes in PBMCs (Figure 6).
Regulation (regulate) of Transcription (expression) of hTERT associated with agonist
4) Confidence 0.18 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.14 Pain Relevance 0.43
Consistent with this, the results of the present study also suggest the involvement of PKC inhibition in the down-regulation of hTERT gene transcription and PKC activation in the upregulation of hTERT gene transcription.
Regulation (regulation) of Transcription (transcription) of hTERT associated with kinase c
5) Confidence 0.18 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.10 Pain Relevance 0.48
Role of c-myc in Receptor Ck dependent regulation of hTERT gene transcription
Regulation (regulation) of Transcription (transcription) of hTERT
6) Confidence 0.18 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0 Pain Relevance 0
silencing on hTERT gene transcription. hTERT mRNA expression was found to increase in PPAR?
Regulation (silencing) of Transcription (transcription) of hTERT
7) Confidence 0.18 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.19 Pain Relevance 0.20
The Receptor Ck dependent down-regulation of hTERT transcription observed in normal human PBMCs may reflect a general mechanism for the repression of hTERT and telomerase expression in normal somatic cells.
Regulation (regulation) of Transcription (transcription) of hTERT in somatic cells associated with repression
8) Confidence 0.18 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.17 Pain Relevance 0.20
In order to assess the involvement of PKC in the Receptor Ck dependent regulation of the transcription of hTERT, c-myc and PPAR?
Regulation (regulation) of Transcription (transcription) of hTERT associated with kinase c
9) Confidence 0.18 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.13 Pain Relevance 0.30
A time-dependent biphasic effect on the mRNA levels of hTERT, c-myc and PPAR?
Regulation (on) of Transcription (levels) of hTERT
10) Confidence 0.18 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.16 Pain Relevance 0.10
In order to determine whether or not c-myc mediates the Receptor Ck dependent down-regulation of hTERT gene transcription, normal human PBMCs cultured in medium containing 10% NHS were exposed to antibody against Receptor Ck along with 1 ?
Spec (whether) Regulation (regulation) of Transcription (transcription) of hTERT
11) Confidence 0.18 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0 Pain Relevance 0
It is likely that as yet unidentified factors are important players in the control of activation and repression of hTERT transcription.
Regulation (control) of Transcription (transcription) of hTERT associated with repression
12) Confidence 0.11 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.46 Pain Relevance 0
In an attempt to identify possible novel mechanisms involved in the regulation of hTERT transcription, the present study examined the role of Receptor Ck, a cell surface receptor specific for cholesterol, in the transcription of hTERT gene in normal human peripheral blood mononuclear cells.


Spec (possible) Regulation (regulation) of Transcription (transcription) of hTERT in mononuclear cells
13) Confidence 0.11 Published 2006 Journal BMC Cell Biol Section Abstract Doc Link PMC1351175 Disease Relevance 0.10 Pain Relevance 0
In this context, Receptor Ck, a cell-surface receptor specific for the cholesterol moiety in lipoprotein particles [13], may be a good candidate for the regulation of hTERT transcription.
Regulation (regulation) of Transcription (transcription) of hTERT
14) Confidence 0.11 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.42 Pain Relevance 0.03
Besides implicating cholesterol (through Receptor Ck) in the transcriptional regulation of hTERT gene, the present study reveals the involvement of oxysterols, the oxygenated derivatives of cholesterol, in the regulation of hTERT gene transcription.
Regulation (regulation) of Transcription (transcription) of hTERT
15) Confidence 0.11 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.34 Pain Relevance 0.08
Our results revealed a novel mechanism for the regulation of hTERT transcription controlled by cholesterol activated Receptor Ck.


Regulation (regulation) of Transcription (transcription) of hTERT
16) Confidence 0.11 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.38 Pain Relevance 0
Although the enormous amount of research has identified numerous protein factors as putative hTERT regulators, the exact mechanisms involved in the regulation of hTERT transcription are still far from being fully established.
Regulation (regulation) of Transcription (transcription) of hTERT
17) Confidence 0.11 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.58 Pain Relevance 0

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