INT189767

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Context Info
Confidence 0.30
First Reported 2006
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 1.43
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

chromosome (TEP1) RNA binding (TEP1) nucleus (TEP1)
cytoplasm (TEP1)
Anatomy Link Frequency
B lymphocytes 2
telomere 2
TEP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 108 59.52 Quite High
Kinase C 47 53.48 Quite High
cytokine 55 25.48 Quite Low
chemokine 8 5.00 Very Low Very Low Very Low
fibrosis 6 5.00 Very Low Very Low Very Low
Inflammatory mediators 4 5.00 Very Low Very Low Very Low
Multiple sclerosis 4 5.00 Very Low Very Low Very Low
rheumatoid arthritis 4 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
agonist 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 75 90.16 High High
Apoptosis 16 87.24 High High
Stress 6 86.52 High High
Increased Venous Pressure Under Development 1 83.00 Quite High
Cataract 19 74.64 Quite High
Aging 12 68.36 Quite High
Repression 4 64.04 Quite High
Keloid Scars 206 63.48 Quite High
Chromosome Aberrations 5 62.16 Quite High
Sprains And Strains 2 60.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, certain highly proliferative human cell types, such as cells in the regenerative basal layer of epidermis [13] and B lymphocytes in the germinal center [14-16], transiently express high levels of telomerase activity upon commitment to clonal expansion.
Positive_regulation (levels) of Gene_expression (express) of telomerase in B lymphocytes
1) Confidence 0.30 Published 2007 Journal Comp Hepatol Section Body Doc Link PMC1920532 Disease Relevance 0.36 Pain Relevance 0
Telomere attrition even in the presence of telomerase suggests that the level of hTERT and telomerase expression is insufficient for the maintenance of telomere lengths.
Positive_regulation (insufficient) of Gene_expression (expression) of telomerase in telomere
2) Confidence 0.06 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.48 Pain Relevance 0.05
Based on preliminary and previously published data, the cells were irradiated with either 0 or 600 J/m2, which can induce expression of both pAkt and telomerase [23,27].
Positive_regulation (induce) of Gene_expression (expression) of telomerase
3) Confidence 0.02 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994344 Disease Relevance 0.07 Pain Relevance 0
Since KPCs constitutively expressed a higher level of IL-6 and IL-6R than SKPs (Figures 3G and 3H; Figure S4C), we next tested whether the intrinsically secreted IL-6 might contribute to the elevated telomerase expression and activity in KPCs.
Spec (might) Positive_regulation (contribute) of Gene_expression (expression) of telomerase
4) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2771422 Disease Relevance 0.26 Pain Relevance 0.03
Since KPCs constitutively expressed a higher level of IL-6 and IL-6R than SKPs (Figures 3G and 3H; Figure S4C), we next tested whether the intrinsically secreted IL-6 might contribute to the elevated telomerase expression and activity in KPCs.
Positive_regulation (elevated) of Gene_expression (expression) of telomerase
5) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2771422 Disease Relevance 0.25 Pain Relevance 0.03

General Comments

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