INT189768

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.44
First Reported 2006
Last Reported 2009
Negated 0
Speculated 2
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 1.56
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

chromosome (TEP1) RNA binding (TEP1) nucleus (TEP1)
cytoplasm (TEP1)
Anatomy Link Frequency
liver 6
blood cells 2
TEP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 94 86.16 High High
Inflammation 69 59.52 Quite High
cytokine 27 25.48 Quite Low
agonist 8 5.00 Very Low Very Low Very Low
anesthesia 6 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
analgesia 3 5.00 Very Low Very Low Very Low
fibrosis 3 5.00 Very Low Very Low Very Low
Bile 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 63 99.48 Very High Very High Very High
Hepatitis 56 98.16 Very High Very High Very High
Repression 8 93.00 High High
Chronic Hepatitis 9 90.68 High High
Keloid Scars 103 63.48 Quite High
INFLAMMATION 74 59.52 Quite High
Hyperplasia 35 56.44 Quite High
Increased Venous Pressure Under Development 2 47.52 Quite Low
Apoptosis 11 41.96 Quite Low
Hepatotoxicity 3 38.84 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pretreatment with these growth factors before partial hepatectomy increased telomerase activation in the remnant liver [17].
Positive_regulation (increased) of Positive_regulation (activation) of telomerase in liver
1) Confidence 0.44 Published 2007 Journal Comp Hepatol Section Body Doc Link PMC1920532 Disease Relevance 0.17 Pain Relevance 0
Based on our results, we propose that telomerase activation in proliferating hepatocytes is the main cause for increased telomerase activity in regenerative liver nodules.
Positive_regulation (cause) of Positive_regulation (increased) of telomerase in liver
2) Confidence 0.30 Published 2007 Journal Comp Hepatol Section Body Doc Link PMC1920532 Disease Relevance 0.39 Pain Relevance 0
Since high levels of telomerase activity have also been detected in leucocytes, it has thus far remained an area of considerable controversy whether increased levels of telomerase activity in liver samples from patients with hepatitis result from telomerase activation in hepatocytes or from infiltrating leucocytes [32].
Spec (whether) Positive_regulation (increased) of Spec (whether) Positive_regulation (levels) of telomerase in liver associated with hepatitis
3) Confidence 0.30 Published 2007 Journal Comp Hepatol Section Body Doc Link PMC1920532 Disease Relevance 0.36 Pain Relevance 0
However, hTERT transcription is upregulated along with the increase in telomerase activity during the activation of peripheral blood cells. [47].
Positive_regulation (upregulated) of Positive_regulation (increase) of telomerase in blood cells
4) Confidence 0.06 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.20 Pain Relevance 0
It is attractive to suggest that the failure of this Receptor Ck dependent repressive mechanism may contribute to upregulation of hTERT transcription and induction of telomerase activity in cancer cells.
Positive_regulation (upregulation) of Positive_regulation (induction) of telomerase associated with cancer
5) Confidence 0.06 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.19 Pain Relevance 0.18
Since KPCs constitutively expressed a higher level of IL-6 and IL-6R than SKPs (Figures 3G and 3H; Figure S4C), we next tested whether the intrinsically secreted IL-6 might contribute to the elevated telomerase expression and activity in KPCs.
Spec (might) Positive_regulation (contribute) of Positive_regulation (elevated) of telomerase
6) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2771422 Disease Relevance 0.26 Pain Relevance 0.03

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox