INT189770

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Context Info
Confidence 0.28
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 12
Disease Relevance 1.36
Pain Relevance 2.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (TERT) DNA binding (TERT) cytoplasm (TERT)
RNA binding (TERT) chromosome (TERT) nucleolus (TERT)
Anatomy Link Frequency
blood cells 2
TERT (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 564 100.00 Very High Very High Very High
agonist 48 97.36 Very High Very High Very High
cINOD 12 31.52 Quite Low
Central nervous system 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 192 98.92 Very High Very High Very High
Targeted Disruption 24 95.68 Very High Very High Very High
Cervical Cancer 12 94.80 High High
Repression 48 93.00 High High
Aging 48 92.48 High High
Colon Cancer 12 79.12 Quite High
Disorder Of Lipid Metabolism 12 56.56 Quite High
Increased Venous Pressure Under Development 12 48.44 Quite Low
Hyperplasia 12 47.36 Quite Low
Apoptosis 36 42.88 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Consistent with this, the results of the present study also suggest the involvement of PKC inhibition in the down-regulation of hTERT gene transcription and PKC activation in the upregulation of hTERT gene transcription.
Positive_regulation (upregulation) of Transcription (transcription) of hTERT associated with kinase c
1) Confidence 0.28 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.09 Pain Relevance 0.47
It is attractive to suggest that the failure of this Receptor Ck dependent repressive mechanism may contribute to upregulation of hTERT transcription and induction of telomerase activity in cancer cells.
Positive_regulation (upregulation) of Transcription (transcription) of hTERT associated with cancer
2) Confidence 0.28 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.19 Pain Relevance 0.15
However, hTERT transcription is upregulated along with the increase in telomerase activity during the activation of peripheral blood cells. [47].
Positive_regulation (upregulated) of Transcription (transcription) of hTERT in blood cells
3) Confidence 0.28 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.20 Pain Relevance 0
Consistent with this, the results of the present study also suggest the involvement of PKC inhibition in the down-regulation of hTERT gene transcription and PKC activation in the upregulation of hTERT gene transcription.
Positive_regulation (upregulation) of Transcription (transcription) of hTERT associated with kinase c
4) Confidence 0.20 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.09 Pain Relevance 0.48
and hTERT transcription observed in this study suggests that PPAR?
Positive_regulation (suggests) of Transcription (transcription) of hTERT
5) Confidence 0.20 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.15 Pain Relevance 0
and hTERT gene transcription, we used PPAR?
Positive_regulation (used) of Transcription (transcription) of hTERT
6) Confidence 0.20 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.18 Pain Relevance 0.12
It is attractive to suggest that the failure of this Receptor Ck dependent repressive mechanism may contribute to upregulation of hTERT transcription and induction of telomerase activity in cancer cells.
Positive_regulation (induction) of Transcription (transcription) of hTERT associated with cancer
7) Confidence 0.20 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.19 Pain Relevance 0.18
activation and hTERT gene transcription.
Positive_regulation (activation) of Transcription (transcription) of hTERT
8) Confidence 0.20 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.16 Pain Relevance 0.34
The exposure of PBMCs to PMA resulted in a gradual increase in mRNA levels of hTERT, c-myc and PPAR?
Positive_regulation (increase) of Transcription (levels) of hTERT
9) Confidence 0.20 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.05 Pain Relevance 0.40
Substantial data have implicated c-myc in the upregulation of hTERT transcription [7].
Positive_regulation (upregulation) of Transcription (transcription) of hTERT
10) Confidence 0.19 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0 Pain Relevance 0
The hTERT transcript levels increased by about 9.3 fold as compared to the levels in control cells after 4 hours of 25OH-C treatment (Figure 5).
Positive_regulation (increased) of Transcription (levels) of hTERT
11) Confidence 0.19 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0 Pain Relevance 0
Role of Bcl-2 and cyclin D in Receptor Ck dependent regulation of hTERT gene transcription
Positive_regulation (dependent) of Transcription (transcription) of hTERT
12) Confidence 0.19 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.06 Pain Relevance 0

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