INT189791

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Context Info
Confidence 0.40
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 4.20
Pain Relevance 0.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cd14) plasma membrane (Cd14)
Anatomy Link Frequency
mononuclear cell 2
Cd14 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 24 99.80 Very High Very High Very High
Inflammation 108 99.56 Very High Very High Very High
antagonist 3 93.52 High High
Crohn's disease 3 93.04 High High
Inflammatory response 52 92.64 High High
cytokine 184 87.76 High High
imagery 3 53.52 Quite High
fibrosis 3 50.48 Quite High
cINOD 9 34.20 Quite Low
tolerance 45 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 8 100.00 Very High Very High Very High
Vasculitis 2 99.56 Very High Very High Very High
Infection 248 99.54 Very High Very High Very High
Chlamydia Infection 36 94.28 High High
Disease 108 93.04 High High
Francisella Infection 28 92.88 High High
INFLAMMATION 159 92.28 High High
Myocardial Infarction 6 92.16 High High
Lyme Disease 39 89.28 High High
Sprains And Strains 87 81.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
which lack CD14 than those expressing CD14.
Negative_regulation (lack) of Gene_expression (expressing) of CD14
1) Confidence 0.40 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2781632 Disease Relevance 0 Pain Relevance 0
This provocative finding was further supported by the ability of shRNA to suppress CD14 expression in M?
Negative_regulation (suppress) of Gene_expression (expression) of CD14
2) Confidence 0.40 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2781632 Disease Relevance 0.23 Pain Relevance 0.08
To better appreciate the individual and combined contribution of CD14 and TLR2 signaling to the M?
Negative_regulation (appreciate) of Gene_expression (contribution) of CD14
3) Confidence 0.40 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2781632 Disease Relevance 0.08 Pain Relevance 0.10
However, several bacterial immune evasion mechanisms have already been identified, including downregulation of CD14 and TLR expression, as well as downregulation of post receptorial signaling machineries [36].
Negative_regulation (downregulation) of Gene_expression (expression) of CD14
4) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2887844 Disease Relevance 0.77 Pain Relevance 0.11
agonist 15d-PGJ2 suppressed microglial expression of MyD88 and CD14
Negative_regulation (suppressed) of Gene_expression (expression) of CD14 associated with agonist
5) Confidence 0.21 Published 2008 Journal PPAR Research Section Body Doc Link PMC2442897 Disease Relevance 0.62 Pain Relevance 0.26
Moreover, the drug reduced vascular inflammation, as it significantly reduced vascular cell adhesion molecule 1 expression and vascular CD14 expression, a marker for mononuclear cell infiltration, in both genotypes.
Negative_regulation (reduced) of Gene_expression (expression) of CD14 in mononuclear cell associated with inflammation, vasculitis and adhesions
6) Confidence 0.20 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988620 Disease Relevance 0.43 Pain Relevance 0.08
However, this does not exclude a prominent role for CD14 in the course of an active C. trachomatis infection and not yet described CD14 expression decreasing SNPs may affect the course of C. trachomatis infection profoundly.
Negative_regulation (decreasing) of Gene_expression (expression) of CD14 associated with infection
7) Confidence 0.14 Published 2005 Journal BMC Infect Dis Section Body Doc Link PMC1351185 Disease Relevance 0.72 Pain Relevance 0.03
Eng et al. demonstrated that carriers of the T allele of this promotor polymorphism have a higher expression of both mCD14 and sCD14 and that TNF?
Negative_regulation (have) of Gene_expression (expression) of mCD14
8) Confidence 0.12 Published 2005 Journal BMC Infect Dis Section Body Doc Link PMC1351185 Disease Relevance 0.67 Pain Relevance 0.08
Eng et al. demonstrated that carriers of the T allele of this promotor polymorphism have a higher expression of both mCD14 and sCD14 and that TNF?
Negative_regulation (have) of Gene_expression (expression) of sCD14
9) Confidence 0.12 Published 2005 Journal BMC Infect Dis Section Body Doc Link PMC1351185 Disease Relevance 0.68 Pain Relevance 0.08

General Comments

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