INT1898

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Context Info
Confidence 0.62
First Reported 1977
Last Reported 2010
Negated 43
Speculated 32
Reported most in Abstract
Documents 220
Total Number 252
Disease Relevance 61.33
Pain Relevance 102.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Crh) extracellular region (Crh) response to stress (Crh)
cytoplasm (Crh)
Anatomy Link Frequency
plasma 18
hypothalamus 17
neurons 14
pituitary 11
nucleus 10
Crh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Opioid 351 100.00 Very High Very High Very High
Morphine 295 100.00 Very High Very High Very High
amygdala 215 100.00 Very High Very High Very High
antagonist 177 100.00 Very High Very High Very High
Pain 160 100.00 Very High Very High Very High
Enkephalin 140 100.00 Very High Very High Very High
Dopamine 111 100.00 Very High Very High Very High
narcan 103 100.00 Very High Very High Very High
Neuropeptide 100 100.00 Very High Very High Very High
cocaine 96 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 420 100.00 Very High Very High Very High
Chronic Renal Failure 248 100.00 Very High Very High Very High
Pain 134 100.00 Very High Very High Very High
Hemorrhage 26 100.00 Very High Very High Very High
Hypertrophy 22 100.00 Very High Very High Very High
Hyperemia 11 100.00 Very High Very High Very High
Hypotension 3 100.00 Very High Very High Very High
Nociception 36 99.98 Very High Very High Very High
Ileus 6 99.98 Very High Very High Very High
Inflammatory Pain 17 99.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effects of acute and chronic fluoxetine treatment on anxiogenic effect of corticotropin-releasing hormone (CRH) were studied in the social interaction test in male Sprague-Dawley rats.
Regulation (effects) of CRH associated with fluoxetine
1) Confidence 0.62 Published 1999 Journal Neuroreport Section Abstract Doc Link 10208588 Disease Relevance 0.07 Pain Relevance 0.57
The current study was proposed to further understand the effects of repeated and acute restraint stress on levels of thalamic CRH mRNA.
Regulation (effects) of CRH associated with stress
2) Confidence 0.62 Published 2001 Journal Brain Res. Section Abstract Doc Link 11578616 Disease Relevance 0.83 Pain Relevance 0.08
Repeated restraint did not alter baseline CRH mRNA levels, but blocked the acute restraint-induced effects.
Neg (not) Regulation (alter) of CRH
3) Confidence 0.62 Published 2001 Journal Brain Res. Section Abstract Doc Link 11578616 Disease Relevance 0.87 Pain Relevance 0.08
There were no changes in either plasma corticosterone or amygdalar CRH mRNA levels after 10-day cocaine withdrawal.
Neg (no) Regulation (changes) of CRH in plasma associated with withdrawal and cocaine
4) Confidence 0.62 Published 2003 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 12782395 Disease Relevance 0.28 Pain Relevance 1.12
Although there are various ways in which the regulation of hypothalamic corticotropin-releasing factor (CRF) may be investigated, the most direct is by the study of CRF secretion from rat hypothalami incubated in vitro.
Regulation (regulation) of CRF
5) Confidence 0.62 Published 1993 Journal Ciba Found. Symp. Section Abstract Doc Link 8491084 Disease Relevance 0.07 Pain Relevance 0.27
The potential role that dopaminergic mechanisms have in the regulation of corticotropin-releasing factor (CRF) in the hypothalamus was investigated.
Regulation (regulation) of CRF in hypothalamus
6) Confidence 0.62 Published 1988 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 2901903 Disease Relevance 0 Pain Relevance 0.23
The potential role that dopaminergic mechanisms have in the regulation of corticotropin-releasing factor (CRF) in the hypothalamus was investigated.
Regulation (regulation) of corticotropin-releasing factor in hypothalamus
7) Confidence 0.62 Published 1988 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 2901903 Disease Relevance 0 Pain Relevance 0.23
The present study investigated whether the serotonergic system is involved in mediating the behavioral effects of corticotropin-releasing hormone (CRH) in juvenile spring chinook salmon, Oncorhynchus tshawytscha.
Regulation (effects) of corticotropin-releasing hormone in juvenile
8) Confidence 0.62 Published 2003 Journal Horm Behav Section Abstract Doc Link 12614652 Disease Relevance 0.09 Pain Relevance 0.40
The present study investigated whether the serotonergic system is involved in mediating the behavioral effects of corticotropin-releasing hormone (CRH) in juvenile spring chinook salmon, Oncorhynchus tshawytscha.
Regulation (effects) of CRH in juvenile
9) Confidence 0.62 Published 2003 Journal Horm Behav Section Abstract Doc Link 12614652 Disease Relevance 0.09 Pain Relevance 0.41
Differential regulation of corticotropin-releasing factor and vasopressin in discrete brain regions after morphine administration: correlations with hypothalamic noradrenergic activity and pituitary-adrenal response.
Regulation (regulation) of corticotropin-releasing factor in brain associated with morphine
10) Confidence 0.62 Published 1997 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Title Doc Link 9402040 Disease Relevance 0 Pain Relevance 0.59
The modification in the activity of noradrenergic neurons projecting to the hypothalamus and the pituitary-adrenal response during morphine withdrawal as well its correlation with alterations in corticotropin-releasing factor (CRF) and vasopressin (AVP) content in different brain areas was analyzed.
Regulation (alterations) of corticotropin-releasing factor in neurons associated with withdrawal and morphine
11) Confidence 0.62 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9580616 Disease Relevance 0 Pain Relevance 0.46
The modification in the activity of noradrenergic neurons projecting to the hypothalamus and the pituitary-adrenal response during morphine withdrawal as well its correlation with alterations in corticotropin-releasing factor (CRF) and vasopressin (AVP) content in different brain areas was analyzed.
Regulation (alterations) of CRF in neurons associated with withdrawal and morphine
12) Confidence 0.62 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9580616 Disease Relevance 0 Pain Relevance 0.46
Administration of RU-486 completely blocked the stress-induced increase of PE mRNA levels, but failed to alter the CRH mRNA levels in the PNV.
Neg (failed) Regulation (alter) of CRH mRNA associated with stress
13) Confidence 0.61 Published 1998 Journal Brain Res. Section Abstract Doc Link 9555022 Disease Relevance 0.35 Pain Relevance 0.09
Marked changes of arginine vasopressin, oxytocin, and corticotropin-releasing hormone in hypophysial portal plasma after pituitary stalk damage in the rat.
Regulation (changes) of corticotropin-releasing hormone in plasma
14) Confidence 0.61 Published 1995 Journal Endocrinology Section Title Doc Link 7720631 Disease Relevance 0.09 Pain Relevance 0.09
These results support a role for neuronal feedback in regulation of the CRH neuron.
Regulation (regulation) of CRH in neuron
15) Confidence 0.60 Published 1990 Journal Endocrinology Section Abstract Doc Link 2171915 Disease Relevance 0 Pain Relevance 0.08
In contrast to CRH gene regulation, PVHmpd proenkephalin mRNA levels were unaffected by corticosterone concentrations.
Regulation (regulation) of CRH gene
16) Confidence 0.60 Published 1998 Journal Endocrinology Section Abstract Doc Link 9724036 Disease Relevance 0.27 Pain Relevance 0
The effects of intraperitoneal and intra-third ventricular administration of morphine on the hypothalamic corticotropin-releasing factor (CRF) and the pituitary-adrenocortical activity were examined in unanesthetized, freely moving rats.
Spec (examined) Regulation (effects) of CRF in pituitary associated with morphine
17) Confidence 0.60 Published 1986 Journal Endocrinol. Jpn. Section Abstract Doc Link 3024953 Disease Relevance 0 Pain Relevance 0.31
Chronic steady-state methadone administration did not alter (a) corticotropin-releasing factor (CRF) mRNA in the hypothalamus, (b) proopiomelanocortin (POMC) and CRF type 1 receptor (CRF-R1) mRNAs in the anterior lobe and neurointermediate/posterior lobe of the pituitary, or (c) circulating levels of corticosterone.
Neg (not) Regulation (alter) of CRF in anterior lobe associated with methadone
18) Confidence 0.60 Published 1996 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8960861 Disease Relevance 0.07 Pain Relevance 0.64
Effects of morphine on hypothalamic corticotropin-releasing factor (CRF), norepinephrine and dopamine in non-stressed and stressed rats.
Regulation (Effects) of CRF associated with dopamine and morphine
19) Confidence 0.60 Published 1985 Journal Acta Med. Okayama Section Title Doc Link 3004111 Disease Relevance 0.23 Pain Relevance 0.85
Effect of morphine on hypothalamic corticotropin-releasing factor (CRF) and pituitary-adrenocortical activity.
Regulation (Effect) of CRF in pituitary associated with morphine
20) Confidence 0.60 Published 1986 Journal Endocrinol. Jpn. Section Title Doc Link 3024953 Disease Relevance 0.07 Pain Relevance 0.42

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