INT18981

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Context Info
Confidence 0.68
First Reported 1982
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 78
Total Number 101
Disease Relevance 38.35
Pain Relevance 61.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (ABAT)
Anatomy Link Frequency
epithelium 16
brain 6
oocytes 4
cortex 3
neuronal 3
ABAT (Homo sapiens)
Pain Link Frequency Relevance Heat
gABA 3273 100.00 Very High Very High Very High
Glutamate 516 100.00 Very High Very High Very High
Dopamine 332 100.00 Very High Very High Very High
agonist 242 100.00 Very High Very High Very High
Serotonin 103 100.00 Very High Very High Very High
central pain 100 100.00 Very High Very High Very High
Pain 93 100.00 Very High Very High Very High
GABA receptor 72 100.00 Very High Very High Very High
Catecholamine 57 100.00 Very High Very High Very High
analgesia 51 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nicotine Addiction 1567 100.00 Very High Very High Very High
Generalized Anxiety Disorder 322 100.00 Very High Very High Very High
Pain 185 100.00 Very High Very High Very High
Neuropathic Pain 40 100.00 Very High Very High Very High
Myalgia 1 100.00 Very High Very High Very High
Epilepsy 41 99.84 Very High Very High Very High
Post-traumatic Stress Disorder 94 99.70 Very High Very High Very High
Death 48 99.68 Very High Very High Very High
Syndrome 108 99.52 Very High Very High Very High
Convulsion 38 99.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effects of these bicyclic monoterpenes alone and with GABA were evaluated at recombinant human alpha(1)beta(2)gamma(2L) GABA(A) receptors expressed in Xenopus laevis oocytes using two-electrode voltage-clamp electrophysiology. (+)-Borneol (EC(50) 248microM) and (-)-borneol (EC(50) 237microM) enhanced the action of low concentrations of GABA by more than 1000%.
Gene_expression (expressed) of GABA in oocytes associated with gaba
1) Confidence 0.68 Published 2005 Journal Biochem. Pharmacol. Section Abstract Doc Link 15763546 Disease Relevance 0 Pain Relevance 0.42
At high concentrations (>1.5mM) (+)- and (-)-borneol directly activated GABA(A) receptors producing 89% and 84%, respectively, of the maximal GABA response indicative of a weak partial agonist action.
Gene_expression (producing) of GABA associated with gaba and agonist
2) Confidence 0.67 Published 2005 Journal Biochem. Pharmacol. Section Abstract Doc Link 15763546 Disease Relevance 0 Pain Relevance 0.62
These results confirm our MRS studies in vivo that gabapentin increases GABA levels in epileptic patients, but has minimal or no effect in a healthy rodent model.
Gene_expression (levels) of GABA associated with epilepsy, gaba and gabapentin
3) Confidence 0.67 Published 2002 Journal Epilepsy Res. Section Abstract Doc Link 12076841 Disease Relevance 0.19 Pain Relevance 0.82
1) Clinical reports of central pain relief after the administration of intrathecal baclofen, a GABA-B agonist.2–6 2) Clinical trials in which tricyclic antidepressant therapy produce analgesia presumably through reversal of GABA inhibition.7 3) Laboratory reports in animals in which application of GABA in the cerebral cortex produced analgesia and intrathecal GABA antagonists produced allodynia and hyperalgesia.8
Gene_expression (produced) of GABA in cerebral cortex associated with pain, central pain, allodynia, tricyclic antidepressant, analgesia, gaba, hyperalgesia, antagonist, agonist, cerebral cortex and intrathecal
4) Confidence 0.61 Published 2010 Journal Perspect Medicin Chem Section Body Doc Link PMC2918363 Disease Relevance 0.77 Pain Relevance 1.87
Systemic administration of GABA-agonists, GABA uptake blockers and inhibitors of GABA-alpha-oxoglutarate transaminase (GABA-T) can produce potent analgesic actions in experimental animals and in man.
Gene_expression (produce) of GABA-alpha-oxoglutarate transaminase associated with gaba, analgesic and agonist
5) Confidence 0.60 Published 1984 Journal Drug Alcohol Depend Section Abstract Doc Link 6096107 Disease Relevance 0.09 Pain Relevance 1.10
Also, gabapentin has not been identified as a GABA reuptake inhibitor, and it is not converted to a GABA agonist.15,17 Gabapentin is a ligand of the ?
Gene_expression (agonist.15,17) of GABA associated with gaba, agonist and gabapentin
6) Confidence 0.59 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2987504 Disease Relevance 0.34 Pain Relevance 1.24
Blockade of GABAA receptors or GABA synthesis regularly evokes convulsive seizures, but administration of many GABA agonists and some GABA uptake blockers paradoxically may evoke myoclonus.
Gene_expression (synthesis) of GABA associated with myoclonus, gaba, convulsion and agonist
7) Confidence 0.58 Published 1990 Journal FASEB J. Section Abstract Doc Link 2165012 Disease Relevance 1.39 Pain Relevance 0.56
There are different expression patterns of some of the GABA-A receptor subunits during rat lung development [24].
Gene_expression (expression) of GABA in lung associated with gaba
8) Confidence 0.57 Published 2010 Journal Respir Res Section Body Doc Link PMC2988726 Disease Relevance 0.08 Pain Relevance 0.54
Assessment of our database of airway epithelial gene expression generated by microarrays showed that, while many of the GABAergic system genes are expressed in the human large and small airway epithelium, cigarette smoking is associated with changes in gene expression only of GAD67, a gene controlling the synthesis of GABA [2].
Gene_expression (synthesis) of GABA in epithelium associated with gaba, nicotine addiction and gabaergic
9) Confidence 0.57 Published 2010 Journal Respir Res Section Body Doc Link PMC2988726 Disease Relevance 0.74 Pain Relevance 0.23
For the GABA metabolism-related genes, both GABAT and ALDH5A1 were expressed in the large and small airway epithelium.
Gene_expression (expressed) of GABAT in epithelium associated with gaba
10) Confidence 0.57 Published 2010 Journal Respir Res Section Body Doc Link PMC2988726 Disease Relevance 0.42 Pain Relevance 0.54
Systemic administration of GABA-agonists, GABA uptake blockers and inhibitors of GABA-alpha-oxoglutarate transaminase (GABA-T) can produce potent analgesic actions in experimental animals and in man.
Gene_expression (produce) of GABA associated with gaba, analgesic and agonist
11) Confidence 0.53 Published 1984 Journal Drug Alcohol Depend Section Abstract Doc Link 6096107 Disease Relevance 0.09 Pain Relevance 1.11
However the paracrine and autocrine effects of GABA potentially confuse the link between central pain and GABA especially when one tries to define GABA effects as exclusively related to synaptic transmission.10,11
Gene_expression (effects) of GABA associated with pain, central pain and gaba
12) Confidence 0.53 Published 2010 Journal Perspect Medicin Chem Section Body Doc Link PMC2918363 Disease Relevance 0.65 Pain Relevance 1.63
Because the molecular structure is not restrained, GABA freely rotates around all three carbon atoms and there exists a myriad of conformations that makes synthesis of active agonists challenging.
Gene_expression (rotates) of GABA associated with gaba and agonist
13) Confidence 0.53 Published 2010 Journal Perspect Medicin Chem Section Body Doc Link PMC2918363 Disease Relevance 0.89 Pain Relevance 1.15
However the paracrine and autocrine effects of GABA potentially confuse the link between central pain and GABA especially when one tries to define GABA effects as exclusively related to synaptic transmission.10,11
Gene_expression (pain) of GABA associated with pain, central pain and gaba
14) Confidence 0.53 Published 2010 Journal Perspect Medicin Chem Section Body Doc Link PMC2918363 Disease Relevance 0.69 Pain Relevance 1.64
In contrast with earlier studies that failed to demonstrate that gabapentin can affect the neuronal content of GABA, more recent evidence suggests that gabapentin may increase GABA synthesis and decrease glutamatergic excitability by depressing astrocytic activity and suppressing glial calcium signaling and glutamate release.20,33 Although the present findings need further critical examination, they suggest that gabapentin functions as a GABA-ergic drug.
Gene_expression (synthesis) of GABA in neuronal associated with glutamate, gaba and gabapentin
15) Confidence 0.52 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2987504 Disease Relevance 0.79 Pain Relevance 1.03
In general, the magnitude of the excitability index change produced by GABA (30 µM) or muscimol (30 µM) increases with increasing basal stimulus rate, i.e. as the prevailing excitability index decreases (Figure 3C & 5D).


Gene_expression (produced) of GABA associated with gaba
16) Confidence 0.52 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808338 Disease Relevance 0 Pain Relevance 0.56
The neurotransmitter GABA is interesting in this respect because in animal models of neuropathic pain GABA pre-synaptically regulates nociceptive input to the spinal cord.
Gene_expression (pre) of GABA in spinal cord associated with nociception, gaba, neurotransmitter, neuropathic pain and spinal cord
17) Confidence 0.52 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2808338 Disease Relevance 0.30 Pain Relevance 0.78
For this analysis, responses to GABA were normalised to the change in excitability index produced by 30 µM GABA.
Gene_expression (produced) of GABA associated with gaba
18) Confidence 0.52 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808338 Disease Relevance 0 Pain Relevance 0.98
Increases in excitability produced by GABA (10–30 µM) were blocked by the GABAA antagonists gabazine (10–20 µM), bicuculline (10–20 µM) and picrotoxin (10–20 µM).


Gene_expression (produced) of GABA associated with gaba and antagonist
19) Confidence 0.52 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2808338 Disease Relevance 0.20 Pain Relevance 0.96
The neurotransmitter GABA is interesting in this respect because in animal models of neuropathic pain GABA pre-synaptically regulates nociceptive input to the spinal cord.
Gene_expression (pre) of GABA in spinal cord associated with nociception, gaba, neurotransmitter, neuropathic pain and spinal cord
20) Confidence 0.52 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2808338 Disease Relevance 0.29 Pain Relevance 0.78

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