INT189833

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Context Info
Confidence 0.51
First Reported 2004
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.10
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Stat1) nucleus (Stat1) enzyme binding (Stat1)
DNA binding (Stat1) cytoplasm (Stat1)
Anatomy Link Frequency
chondrocyte 2
Stat1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 12 87.04 High High
agonist 22 78.64 Quite High
Inflammation 26 70.12 Quite High
Neuropeptide 1 61.00 Quite High
Cannabinoid receptor 5 50.00 Quite Low
Central nervous system 12 19.44 Low Low
Cannabinoid 11 5.00 Very Low Very Low Very Low
Multiple sclerosis 8 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Potency 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Leukemia 14 93.52 High High
Philadelphia Chromosome 12 93.32 High High
Repression 1 90.80 High High
Myeloid Leukemia 39 87.12 High High
Sarcoma 4 85.20 High High
Hematological Disease 1 82.12 Quite High
Osteochondroma 40 79.44 Quite High
Arrhythmias 2 Under Development 1 70.44 Quite High
INFLAMMATION 31 70.12 Quite High
Pressure And Volume Under Development 2 69.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Densitometric analyis of western blot data from N9 cell lysates in Figure 4B indicate significant reductions in STAT1 phosphorylation at serine residue 727 (p < 0.01) with both apigenin and luteolin treatment.
Negative_regulation (reductions) of Phosphorylation (phosphorylation) of STAT1
1) Confidence 0.51 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2569027 Disease Relevance 0.13 Pain Relevance 0.09
Results showed that JWH-015 co-treatment significantly inhibited Ser727 phosphorylation of the STAT1 protein at 10 ?
Negative_regulation (inhibited) of Phosphorylation (phosphorylation) of STAT1
2) Confidence 0.46 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1352348 Disease Relevance 0.06 Pain Relevance 0.21
In patients with AP or BP who received nilotinib 400 mg or 600 mg twice daily, a significant decrease in phosphorylation of AKT, CRKL, STAT1, and STAT5 was observed on day 15 of therapy compared with baseline (Kantarjian et al 2006).
Negative_regulation (decrease) of Phosphorylation (phosphorylation) of STAT1
3) Confidence 0.25 Published 2008 Journal OncoTargets and therapy Section Body Doc Link PMC2994207 Disease Relevance 0.55 Pain Relevance 0
In contrast, activation of FGFR3 in the proliferative zone (Fig. 5), by FGF18 [84] inhibits chondrocyte proliferation via phosphorylation of STAT-1 and subsequent upregulation of p21WAF/CIP1, which can inhibit the cell cycle [85].
Negative_regulation (inhibits) of Phosphorylation (phosphorylation) of STAT-1 in chondrocyte
4) Confidence 0.03 Published 2004 Journal Hered Cancer Clin Pract Section Body Doc Link PMC2840003 Disease Relevance 0.37 Pain Relevance 0

General Comments

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