INT189834

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Context Info
Confidence 0.36
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 0.72
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Stat1) nucleus (Stat1) enzyme binding (Stat1)
DNA binding (Stat1) cytoplasm (Stat1)
Anatomy Link Frequency
microglial cells 2
Stat1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 44 95.32 Very High Very High Very High
agonist 23 83.96 Quite High
Inflammation 41 77.04 Quite High
Neuropeptide 1 69.28 Quite High
Cannabinoid receptor 5 50.00 Quite Low
Inflammatory mediators 2 42.40 Quite Low
IPN 2 7.28 Low Low
Cannabinoid 11 5.00 Very Low Very Low Very Low
Multiple sclerosis 7 5.00 Very Low Very Low Very Low
Inflammatory response 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 36 91.24 High High
Disorder Of Lipid Metabolism 4 89.28 High High
Atherosclerosis 22 88.56 High High
Inflammatory Bowel Disease 38 77.92 Quite High
INFLAMMATION 48 77.04 Quite High
Obesity 4 68.48 Quite High
Targeted Disruption 2 42.72 Quite Low
Colitis 19 27.16 Quite Low
Renal Disease 2 9.52 Low Low
Body Weight 5 9.20 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Accordingly, we examined the effects of CB2 stimulation on STAT1 phosphorylation, in the same dose range mentioned above, on primary microglial cells treated with IFN-?
Spec (examined) Regulation (effects) of Phosphorylation (phosphorylation) of STAT1 in microglial cells
1) Confidence 0.36 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1352348 Disease Relevance 0 Pain Relevance 0.22
Therefore, we wanted to study the effects of PEO on activated (phosphorylated at Tyr701) STAT1 (pSTAT1).
Regulation (effects) of Phosphorylation (phosphorylated) of pSTAT1
2) Confidence 0.20 Published 2010 Journal BMC Chem Biol Section Body Doc Link PMC2881005 Disease Relevance 0.30 Pain Relevance 0.04
Indeed, the action of PI3K in these cases appears to be mediated, at least in part, through the regulation of STAT1 serine 727 phosphorylation [11].
Regulation (regulation) of Phosphorylation (phosphorylation) of STAT1
3) Confidence 0.15 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0.42 Pain Relevance 0.05
signalling through the regulation of STAT1 phosphorylation at serine 727, which is necessary for maximal transcriptional activity [11].
Regulation (regulation) of Phosphorylation (phosphorylation) of STAT1
4) Confidence 0.15 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0 Pain Relevance 0

General Comments

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