INT189836

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Context Info
Confidence 0.40
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 3.02
Pain Relevance 1.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cd40) extracellular region (Cd40) plasma membrane (Cd40)
enzyme binding (Cd40)
Anatomy Link Frequency
B cells 2
Macrophages 1
CD86 1
CII 1
T cells 1
Cd40 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 81 97.84 Very High Very High Very High
tolerance 35 95.96 Very High Very High Very High
imagery 45 90.60 High High
agonist 22 89.76 High High
chemokine 4 89.20 High High
Potency 1 84.56 Quite High
rheumatoid arthritis 69 84.40 Quite High
Arthritis 133 82.92 Quite High
Cannabinoid 11 81.52 Quite High
Deep tissue 2 80.60 Quite High
Disease Link Frequency Relevance Heat
Disease 117 94.36 High High
Arthritis 57 88.16 High High
Targeted Disruption 37 86.40 High High
Injury 1 84.48 Quite High
Rheumatoid Arthritis 69 84.40 Quite High
Immunization 53 83.72 Quite High
Experimental Arthritis 80 82.92 Quite High
Disease Progression 8 82.64 Quite High
Autoimmune Disease 53 80.64 Quite High
Mycobacterial Infection 5 79.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We previously reported that mechanisms that antagonize microglial CD40 expression or CD40 signaling could also block microglial production of proinflammatory mediators [27].
Regulation (antagonize) of CD40
1) Confidence 0.40 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1352348 Disease Relevance 0.31 Pain Relevance 0.28
Silencing was specific in that CD 40 siRNA did not change gene expression of CD80 in DCs (Figure 1C).
Neg (not) Regulation (change) of CD 40
2) Confidence 0.39 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875641 Disease Relevance 0.24 Pain Relevance 0.07
Specifically, the expression levels of CD40, CD80, CD86 and MHC II were evaluated in unlabeled, SPIO-loaded and PMA-activated B cells via flow cytometry, Fig. 1D.
Regulation (evaluated) of CD40 in B cells
3) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2871797 Disease Relevance 0.09 Pain Relevance 0.13
N-acetyl-L-cysteine (NAC), an antioxidant, was shown to inhibit both the up-regulation of CD40 and the isotype switching to IgE by IL-4 (Yanagihara et al., 1997), and also to affect in vitro B cell proliferation induced by CD40 ligation (Lee, 2003).
Regulation (regulation) of CD40 in B cell
4) Confidence 0.32 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998772 Disease Relevance 0.11 Pain Relevance 0.04
We observed that administration of siRNA targeting CD40 could induce in vivo inhibition of proliferative and cytokine recall response to the joint antigen CII, as well as prophylactically inhibit disease.
Regulation (targeting) of CD40 in CII associated with disease and cytokine
5) Confidence 0.27 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875641 Disease Relevance 0.63 Pain Relevance 0.19
In this study, we used a hydrodynamic protocol to systemically administer siRNA targeting CD40 in mice before and after administration of autoreactive antigen.
Regulation (targeting) of CD40
6) Confidence 0.27 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875641 Disease Relevance 0.54 Pain Relevance 0.12
The effects seen after inhibition of CD40 might be attributable to a direct effect on CD40 in B cells or an indirect effect through lower activation of T cells.
Regulation (effect) of CD40 in T cells
7) Confidence 0.27 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875641 Disease Relevance 0.43 Pain Relevance 0.03
Macrophages of apoE-deficient mice stimulated by exogenous antigen are more effective in the upregulating of main histocompatibility complex (MHC) class II molecules and costimulatory molecules like CD40 and CD80, with increased IFN-?
Regulation (upregulating) of CD40 in Macrophages
8) Confidence 0.24 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2825561 Disease Relevance 0.32 Pain Relevance 0.07
Ligands for ICOS are constitutively expressed on APCs and, in contrast to CD80 and CD86, do not underlie the control of CD40 or signals involving the NF-?
Regulation (control) of CD40 in CD86
9) Confidence 0.12 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2582810 Disease Relevance 0.34 Pain Relevance 0.08
Both CD80 and CD40 were up-regulated in the presence of LPS, but addition of SGE did not alter this expression (Figure 1A).
Regulation (regulated) of CD40
10) Confidence 0.09 Published 2010 Journal Parasit Vectors Section Body Doc Link PMC2993695 Disease Relevance 0 Pain Relevance 0.10

General Comments

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