INT189838

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Context Info
Confidence 0.41
First Reported 2005
Last Reported 2009
Negated 0
Speculated 2
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.19
Pain Relevance 1.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cnr2) plasma membrane (Cnr2) signal transducer activity (Cnr2)
Anatomy Link Frequency
microglial cells 4
Cnr2 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 62 100.00 Very High Very High Very High
Neuropathic pain 17 99.84 Very High Very High Very High
allodynia 8 97.20 Very High Very High Very High
cytokine 14 95.32 Very High Very High Very High
Spinal cord 16 86.84 High High
Pain 17 82.24 Quite High
Inflammation 20 79.52 Quite High
Thalamus 2 77.44 Quite High
Endocannabinoid 44 72.96 Quite High
Neuropeptide 2 69.28 Quite High
Disease Link Frequency Relevance Heat
Neuropathic Pain 29 99.84 Very High Very High Very High
Pain 26 82.24 Quite High
INFLAMMATION 25 79.52 Quite High
Targeted Disruption 11 79.00 Quite High
Nociception 15 68.76 Quite High
Hyperalgesia 9 40.52 Quite Low
Disease 30 5.00 Very Low Very Low Very Low
Multiple Sclerosis 20 5.00 Very Low Very Low Very Low
Injury 10 5.00 Very Low Very Low Very Low
Inflammatory Pain 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Accordingly, we examined the effects of CB2 stimulation on STAT1 phosphorylation, in the same dose range mentioned above, on primary microglial cells treated with IFN-?
Spec (examined) Regulation (effects) of Spec (examined) Positive_regulation (stimulation) of CB2 in microglial cells
1) Confidence 0.41 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1352348 Disease Relevance 0 Pain Relevance 0.22
To examine the functional consequences of CB2 agonist treatment on CD40 expression, we stimulated mouse primary microglial cells with either IFN-?
Spec (examine) Regulation (consequences) of Spec (examine) Positive_regulation (treatment) of CB2 in microglial cells associated with agonist
2) Confidence 0.41 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1352348 Disease Relevance 0.14 Pain Relevance 0.19
Furthermore, the robust inhibitory effects of CB2 receptor activation on neuropathic pain behaviour have been shown to be interferon-?
Regulation (effects) of Positive_regulation (activation) of CB2 associated with neuropathic pain
3) Confidence 0.19 Published 2009 Journal Mol Pain Section Body Doc Link PMC2770047 Disease Relevance 1.05 Pain Relevance 1.11

General Comments

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