INT189842

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Context Info
Confidence 0.59
First Reported 2005
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 8
Total Number 10
Disease Relevance 4.21
Pain Relevance 4.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cnr2) plasma membrane (Cnr2) signal transducer activity (Cnr2)
Anatomy Link Frequency
brain 4
striatum 2
cerebellum 2
Cnr2 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 196 100.00 Very High Very High Very High
alcohol 150 99.68 Very High Very High Very High
Pain 79 99.12 Very High Very High Very High
Opioid 11 98.88 Very High Very High Very High
Lasting pain 5 97.16 Very High Very High Very High
Cannabinoid receptor 26 96.96 Very High Very High Very High
midbrain 25 96.80 Very High Very High Very High
Analgesic 22 94.52 High High
Intracerebroventricular 36 93.36 High High
Cannabinoid 118 92.48 High High
Disease Link Frequency Relevance Heat
Pain 91 99.12 Very High Very High Very High
Stress 194 98.48 Very High Very High Very High
Targeted Disruption 36 98.12 Very High Very High Very High
Cancer 8 96.28 Very High Very High Very High
Anxiety Disorder 12 93.80 High High
Neuropathic Pain 46 89.36 High High
Ganglion Cysts 6 85.80 High High
Drug Dependence 85 81.84 Quite High
Depression 223 81.24 Quite High
Sprains And Strains 66 79.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In mice subjected to the chronic varying alcohol intake paradigm for alcohol preference, there was significant reduction CB2 gene expression in the striatum (P?
Negative_regulation (reduction) of Gene_expression (expression) of CB2 gene in striatum associated with alcohol
1) Confidence 0.59 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2241668 Disease Relevance 0.14 Pain Relevance 0.67
Mice that developed alcohol preference had reduced CB2 gene expression and chronic treatment with JWH015 a putative CB2-R agonist, enhanced alcohol consumption in stressed but not in control mice.
Negative_regulation (reduced) of Gene_expression (expression) of CB2 gene associated with agonist and alcohol
2) Confidence 0.59 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2241668 Disease Relevance 0.61 Pain Relevance 0.63
To investigate whether CB2-R gene targeting by CB2-R antisense oligonucleotide (oligo) modifies behavior, we determined whether inhibition of CB2 gene expression in the brain will alter mouse behavior in the elevated plus-maze test.
Spec (whether) Negative_regulation (inhibition) of Gene_expression (expression) of CB2 gene in brain
3) Confidence 0.59 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2241668 Disease Relevance 0.37 Pain Relevance 0.32
It is therefore of importance to determine whether inhibition of CB2 gene expression in the brain will alter behavior as observed with the exogenous administration of CB2-R ligands.
Spec (whether) Negative_regulation (inhibition) of Gene_expression (expression) of CB2 gene in brain
4) Confidence 0.59 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2241668 Disease Relevance 0.69 Pain Relevance 0.54
Effects of CB2-R activation and blockade on anhedonia induced by chronic mild stress (CMS)
Negative_regulation (blockade) of Gene_expression (activation) of CB2-R associated with stress
5) Confidence 0.43 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2241668 Disease Relevance 0.79 Pain Relevance 0.31
In addition, to evaluate the knock-down efficiency, we performed Western blot using anti-CB2 antibody and found a significantly decreased level of CB2 expression in siRNA transfected condition (Figure 3B).
Negative_regulation (decreased) of Gene_expression (expression) of CB2 associated with targeted disruption
6) Confidence 0.39 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1352348 Disease Relevance 0.10 Pain Relevance 0.14
Therefore, very rigorous controls have been utilized in our study including 1) the pre-adsorption and co-incubation of the CB2-R antibody with the immunizing peptide resulting in blocking CB2 staining in the rat cerebellum, 2) in situ hybridization data show that CB2 gene is expressed in the cerebellum of wild type and not in the CB2 knockout mice, with CB2 gene being absent in the sense control in the wild type mice.
Negative_regulation (blocking) of Gene_expression (staining) of CB2 in cerebellum associated with targeted disruption
7) Confidence 0.37 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2241668 Disease Relevance 0.18 Pain Relevance 0.18
N9 cells were transfected with specific murine CB2 targeting siRNA designed to knockdown murine CB2 expression (Humesis Biotechnology Corporation, New Orleans, LA).
Negative_regulation (knockdown) of Gene_expression (expression) of CB2
8) Confidence 0.34 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1352348 Disease Relevance 0 Pain Relevance 0
In addition, this CB2 agonist markedly inhibited IFN-?
Negative_regulation (inhibited) of Gene_expression (agonist) of CB2 associated with agonist
9) Confidence 0.34 Published 2005 Journal J Neuroinflammation Section Abstract Doc Link PMC1352348 Disease Relevance 0.55 Pain Relevance 0.48
Studies have also shown CB2 selective agonists to modulate pain without central CB1-like side effects.61
Negative_regulation (shown) of Gene_expression (selective) of CB2 associated with pain and agonist
10) Confidence 0.08 Published 2010 Journal Journal of pain research Section Body Doc Link PMC3004649 Disease Relevance 0.78 Pain Relevance 1.39

General Comments

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