INT189844

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Context Info
Confidence 0.01
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 0.79
Pain Relevance 1.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cnr2) plasma membrane (Cnr2) nucleus (Churc1)
DNA binding (Churc1) signal transducer activity (Cnr2)
Churc1 (Mus musculus)
Cnr2 (Mus musculus)
Pain Link Frequency Relevance Heat
Cannabinoid receptor 15 100.00 Very High Very High Very High
agonist 66 95.28 Very High Very High Very High
Cannabinoid 33 84.40 Quite High
Inflammation 15 78.68 Quite High
chemokine 3 68.44 Quite High
cytokine 21 67.80 Quite High
Inflammatory mediators 3 66.32 Quite High
Neuropeptide 3 65.68 Quite High
Multiple sclerosis 21 63.72 Quite High
Central nervous system 18 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 6 92.12 High High
INFLAMMATION 21 78.68 Quite High
Dementia 3 64.48 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 12 64.12 Quite High
Multiple Sclerosis 30 63.72 Quite High
Disease 45 62.72 Quite High
Neurodegenerative Disease 12 61.32 Quite High
Necrosis 6 5.00 Very Low Very Low Very Low
Cancer 6 5.00 Very Low Very Low Very Low
Overdose 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data indicate that JWH-015 is activating CB2 to oppose the TNF-?
JWH-015 Positive_regulation (activating) of CB2
1) Confidence 0.01 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1352348 Disease Relevance 0.09 Pain Relevance 0.15
Finally, we showed that CB2 activation by JWH-015 markedly attenuated CD40-mediated inhibition of microglial phagocytosis of A?
JWH-015 Positive_regulation (activation) of CB2
2) Confidence 0.01 Published 2005 Journal J Neuroinflammation Section Abstract Doc Link PMC1352348 Disease Relevance 0.11 Pain Relevance 0.37
We found that the selective stimulation of cannabinoid receptor CB2 by JWH-015 suppressed IFN-?
JWH-015 Positive_regulation (stimulation) of cannabinoid receptor CB2 associated with cannabinoid receptor
3) Confidence 0.01 Published 2005 Journal J Neuroinflammation Section Abstract Doc Link PMC1352348 Disease Relevance 0.59 Pain Relevance 0.50

General Comments

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