INT189859

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Context Info
Confidence 0.32
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.68
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (SLC6A3) cell death (SLC6A3) aging (SLC6A3)
plasma membrane (SLC6A3) transmembrane transport (SLC6A3) cytoplasm (SLC6A3)
SLC6A3 (Homo sapiens)
ADHD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 41 100.00 Very High Very High Very High
transdermal 3 93.72 High High
imagery 2 84.48 Quite High
Neurotransmitter 10 78.40 Quite High
Serotonin 9 53.20 Quite High
dopamine receptor 1 50.12 Quite High
Central nervous system 1 37.16 Quite Low
sSRI 4 31.48 Quite Low
drug abuse 16 5.00 Very Low Very Low Very Low
Clonidine 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Attention Deficit Hyperactivity Disorder 344 100.00 Very High Very High Very High
Targeted Disruption 1 99.64 Very High Very High Very High
Syndrome 6 9.24 Low Low
Substance Abuse 30 5.00 Very Low Very Low Very Low
Conduct Disorder 18 5.00 Very Low Very Low Very Low
Attention Deficit And Disruptive Behavior Disorders 13 5.00 Very Low Very Low Very Low
Depression 10 5.00 Very Low Very Low Very Low
Autism 9 5.00 Very Low Very Low Very Low
Cognitive Disorder 8 5.00 Very Low Very Low Very Low
Sleep Disorders 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast to the association of ADHD in humans with elevated DAT1 levels, knockout mice that have no DAT1 gene are also very hyperactive [55].
DAT1 Binding (association) of ADHD associated with targeted disruption and attention deficit hyperactivity disorder
1) Confidence 0.32 Published 2005 Journal Theor Biol Med Model Section Body Doc Link PMC1352384 Disease Relevance 0.53 Pain Relevance 0.32
Dexmethylphenidate (FocalinĀ®) is a more potent d-threo enantiomer of racemic methylphenidate approved for ADHD treatment with a high affinity for dopamine transporter (DAT) and requires only half the total dose of immediate acting MPH preparations.
DAT Binding (affinity) of ADHD associated with dopamine and attention deficit hyperactivity disorder
2) Confidence 0.32 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732009 Disease Relevance 0.15 Pain Relevance 0.16

General Comments

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