INT189863

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Context Info
Confidence 0.68
First Reported 2004
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 11
Total Number 12
Disease Relevance 7.65
Pain Relevance 2.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (DRD4) cytoplasm (DRD4) signal transducer activity (DRD4)
DRD4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 302 100.00 Very High Very High Very High
depression 38 100.00 Very High Very High Very High
addiction 109 99.56 Very High Very High Very High
Nicotine 188 99.12 Very High Very High Very High
bDMF 4 94.88 High High
alcohol 31 93.40 High High
Serotonin 98 86.80 High High
positron emission tomography 12 76.72 Quite High
dopamine receptor 24 73.92 Quite High
withdrawal 24 69.16 Quite High
Disease Link Frequency Relevance Heat
Depression 44 100.00 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 1204 99.84 Very High Very High Very High
Nicotine Addiction 367 99.56 Very High Very High Very High
Conduct Disorder 72 95.68 Very High Very High Very High
Intellectual Impairment 4 84.40 Quite High
Syndrome 18 82.96 Quite High
Attention Deficit And Disruptive Behavior Disorders 52 79.76 Quite High
Impulse Control Disorders 27 64.00 Quite High
Anxiety Disorder 18 62.84 Quite High
Substance Withdrawal Syndrome 6 58.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Finally, DRD4 VNTR genotype was not associated with delayed reward discounting in general (F [1, 158] ?
Gene_expression (genotype) of DRD4 VNTR
1) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2994774 Disease Relevance 0.63 Pain Relevance 0.23
Influences of DRD2 TaqI A and DRD4 VNTR genotypes on impulsivity
Gene_expression (genotypes) of DRD4 VNTR associated with attention deficit hyperactivity disorder
2) Confidence 0.66 Published 2007 Journal Behav Brain Funct Section Body Doc Link PMC1781951 Disease Relevance 0.44 Pain Relevance 0
DRD4 VNTR allele frequencies and genotypes are presented in Table 3, and were in HW equilibrium (Markov Chain algorithm, p = 0.38).


Gene_expression (presented) of DRD4 VNTR
3) Confidence 0.66 Published 2007 Journal Behav Brain Funct Section Body Doc Link PMC1781951 Disease Relevance 0 Pain Relevance 0
To assure missing responses were not systematically biased by genotype, missing versus non-missing data for each psychometric scale was analyzed across both DRD2 TaqI A and DRD4 VNTR genotypes via 2 × 2 contingency tables.
Spec (analyzed) Gene_expression (genotypes) of DRD4 VNTR
4) Confidence 0.66 Published 2007 Journal Behav Brain Funct Section Body Doc Link PMC1781951 Disease Relevance 0 Pain Relevance 0
Thus, particularly steep delay discounting (increased impulsivity) in those with both long DRD4 and A1 DRD2 alleles may reflect the concurrent variation in two key points in the reward decision-making loops spanning the corticostriatal-mesolimbic axis.
Gene_expression (alleles) of DRD4 associated with attention deficit hyperactivity disorder
5) Confidence 0.66 Published 2007 Journal Behav Brain Funct Section Body Doc Link PMC1781951 Disease Relevance 0.18 Pain Relevance 0.07
p2 = .047), as was the interaction effect of DRD2 and DRD4 on DDT k (F (1,74) = 2.729, p = .103, ?
Gene_expression (effect) of DRD4
6) Confidence 0.66 Published 2007 Journal Behav Brain Funct Section Body Doc Link PMC1781951 Disease Relevance 0.12 Pain Relevance 0
In this regard, Lee et al. [46] found an association between novelty seeking (NS) and both the dopamine D4 receptor gene (DRD4) long alleles and the Taq1 A1 and Taq1 B1 sites of the dopamine D2 receptor gene.
Gene_expression (seeking) of DRD4 associated with dopamine
7) Confidence 0.52 Published 2005 Journal Theor Biol Med Model Section Body Doc Link PMC1352384 Disease Relevance 0.56 Pain Relevance 0.38
DRD4 Dopamine D4 receptor gene
Gene_expression (gene) of DRD4 associated with dopamine
8) Confidence 0.52 Published 2005 Journal Theor Biol Med Model Section Body Doc Link PMC1352384 Disease Relevance 1.79 Pain Relevance 0.49
In this regard, Lee et al. [46] found an association between novelty seeking (NS) and both the dopamine D4 receptor gene (DRD4) long alleles and the Taq1 A1 and Taq1 B1 sites of the dopamine D2 receptor gene.
Gene_expression (seeking) of dopamine D4 receptor associated with dopamine
9) Confidence 0.52 Published 2005 Journal Theor Biol Med Model Section Body Doc Link PMC1352384 Disease Relevance 0.56 Pain Relevance 0.38
DRD4 Dopamine D4 receptor gene
Gene_expression (gene) of Dopamine D4 receptor associated with dopamine
10) Confidence 0.46 Published 2005 Journal Theor Biol Med Model Section Body Doc Link PMC1352384 Disease Relevance 1.79 Pain Relevance 0.49
In a combined sample, a significant interaction was seen between depression and DRD4, in which depressed smokers homozygous for the short alleles of DRD4 were more likely to smoke to reduce negative feelings and to smoke in response to stimulation [23].
Gene_expression (depression) of DRD4 associated with nicotine addiction and depression
11) Confidence 0.31 Published 2004 Journal Tob Induc Dis Section Body Doc Link PMC2669467 Disease Relevance 0.79 Pain Relevance 0.32
In a combined sample, a significant interaction was seen between depression and DRD4, in which depressed smokers homozygous for the short alleles of DRD4 were more likely to smoke to reduce negative feelings and to smoke in response to stimulation [23].
Gene_expression (depression) of DRD4 associated with nicotine addiction and depression
12) Confidence 0.31 Published 2004 Journal Tob Induc Dis Section Body Doc Link PMC2671538 Disease Relevance 0.79 Pain Relevance 0.32

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