INT189876

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Context Info
Confidence 0.14
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.29
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (TJP1) plasma membrane (TJP1) nucleus (TJP1)
cytoplasm (TJP1)
TJP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
ischemia 45 84.08 Quite High
Inflammation 25 5.00 Very Low Very Low Very Low
cytokine 10 5.00 Very Low Very Low Very Low
Inflammatory response 10 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
Infliximab 2 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
isoflurane 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 33 90.68 High High
Cv Unclassified Under Development 38 84.08 Quite High
Cv General 4 Under Development 7 50.00 Quite Low
Apoptosis 26 49.56 Quite Low
Celiac Disease 58 48.20 Quite Low
Disease 73 25.88 Quite Low
Targeted Disruption 5 6.40 Low Low
INFLAMMATION 33 5.00 Very Low Very Low Very Low
Infection 26 5.00 Very Low Very Low Very Low
Sprains And Strains 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Further, we stained ZO-1, a 225 kDa membrane bound protein, binding the transmembrane tight junction proteins occludin and claudins and linking them to cytoskeletal actin [28].
ZO-1 Binding (binding) of
1) Confidence 0.14 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2561292 Disease Relevance 0.20 Pain Relevance 0.10
Alternatively, the process of tight junction formation and remodeling may involve interactions between tight junction proteins, the scaffolding protein ZO-1, and the E-cadherin complex that could result in E-cadherin exposure on the apical surface [75].
ZO-1 Binding (interactions) of
2) Confidence 0.02 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1354196 Disease Relevance 0 Pain Relevance 0
The tight and adherens junctions are connected to the actin cytoskeleton by associated proteins zonula occludins 1 (ZO-1) and ?
ZO-1 Binding (associated) of
3) Confidence 0.02 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2323203 Disease Relevance 0.09 Pain Relevance 0

General Comments

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