INT189877

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Context Info
Confidence 0.58
First Reported 2006
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 55
Total Number 55
Disease Relevance 9.36
Pain Relevance 0.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Cdh1) Golgi apparatus (Cdh1) plasma membrane (Cdh1)
cytoplasm (Cdh1)
Anatomy Link Frequency
lactotrophs 5
mesodermal cells 4
anterior pituitary 4
plasma 3
amniotic cavity 2
Cdh1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 44 95.24 Very High Very High Very High
Central nervous system 28 90.88 High High
alcohol 5 86.60 High High
Inflammatory response 2 82.48 Quite High
fibrosis 62 78.32 Quite High
cytokine 19 71.12 Quite High
agonist 7 54.88 Quite High
Inflammation 59 51.00 Quite High
anesthesia 65 32.36 Quite Low
isoflurane 17 12.96 Low Low
Disease Link Frequency Relevance Heat
Targeted Disruption 59 99.88 Very High Very High Very High
Adhesions 397 99.80 Very High Very High Very High
Coronary Artery Disease 396 98.80 Very High Very High Very High
Familial Adenomatous Polyposis 6 94.52 High High
Ureteral Obstruction 120 93.16 High High
Injury 20 88.52 High High
Apoptosis 50 82.96 Quite High
INFLAMMATION 60 82.48 Quite High
Stress 40 82.00 Quite High
Fibrosis 114 79.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As shown in Figure 1, exogenous E-cadherin was detected in cytoplasm, which suggests that the catenin complex present was insufficient for the amount of E-cadherin that had been overexpressed.
Gene_expression (overexpressed) of E-cadherin
1) Confidence 0.58 Published 2010 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2875860 Disease Relevance 0.12 Pain Relevance 0
Prolactin immunoreactivities and mRNA signals in hormone-producing cells expressing E-cadherin
Gene_expression (expressing) of E-cadherin
2) Confidence 0.58 Published 2010 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2875860 Disease Relevance 0.42 Pain Relevance 0
Thus, factitious expression of E-cadherin would alter cytoskeletal structure of lactotrophs, and the change could accelerate trafficking of secretory granules, which may be another reason for the decreased prolactin content in transfected lactotrophs.
Gene_expression (expression) of E-cadherin in lactotrophs
3) Confidence 0.58 Published 2010 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2875860 Disease Relevance 0 Pain Relevance 0
The present study has shown that forced E-cadherin expression in lactotrophs of adult rats significantly reduced prolactin content.
Gene_expression (expression) of E-cadherin in lactotrophs
4) Confidence 0.58 Published 2010 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2875860 Disease Relevance 0 Pain Relevance 0
There are many types of cadherin, including E-cadherin, which is expressed mainly in epithelial tissues, and N-cadherin, which is expressed in neural tissues [23].
Gene_expression (expressed) of E-cadherin in neural
5) Confidence 0.58 Published 2010 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2875860 Disease Relevance 0.18 Pain Relevance 0
It is unlikely that E-cadherin expression inhibited translation, which leaves two possibilities.
Gene_expression (expression) of E-cadherin
6) Confidence 0.58 Published 2010 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2875860 Disease Relevance 0.31 Pain Relevance 0
Forced expression of E-cadherin in hormone-producing cells in the anterior pituitary of adult rats
Gene_expression (expression) of E-cadherin in anterior pituitary
7) Confidence 0.58 Published 2010 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2875860 Disease Relevance 0.13 Pain Relevance 0
One of the most important effects of E-cadherin expression on cell phenotype appears on cytoskeletal fibers.
Gene_expression (expression) of E-cadherin
8) Confidence 0.58 Published 2010 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2875860 Disease Relevance 0.05 Pain Relevance 0
Thus, to confirm forced E-cadherin expression in hormone-producing cells, we transfected purified hormone-producing cells with rE-cad-IZ.
Gene_expression (expression) of E-cadherin associated with coronary artery disease
9) Confidence 0.58 Published 2010 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2875860 Disease Relevance 0.43 Pain Relevance 0
We are inclined to conclude that this result is linked to the observation that E-cadherin expression is lost in hormone-producing cells at the onset of hormone production in the developing adenohypophysis [9].



Gene_expression (expression) of E-cadherin in adenohypophysis
10) Confidence 0.58 Published 2010 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2875860 Disease Relevance 0 Pain Relevance 0
In addition, Kikuchi et al. reported that cells in the adenohypophyseal placode co-expressed both E- and N-cadherin, and that hormone-producing cells lost expression of E-cadherin during cell differentiation [9, 10].
Gene_expression (expression) of E-cadherin in adenohypophyseal placode
11) Confidence 0.58 Published 2010 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2875860 Disease Relevance 0.12 Pain Relevance 0
As shown in Figure 1, exogenous E-cadherin was detected in cytoplasm, which suggests that the catenin complex present was insufficient for the amount of E-cadherin that had been overexpressed.
Gene_expression (detected) of E-cadherin
12) Confidence 0.50 Published 2010 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2875860 Disease Relevance 0.19 Pain Relevance 0
We detected N-cadherin on the plasma membrane (Fig. 1D and 1F) and E-cadherin both on the plasma membrane and in the cytoplasm of all cells transfected with the rE-cad-IZ plasmid (indicated by arrows in Fig. 1D, 1F, and 1H).
Gene_expression (detected) of E-cadherin in plasma associated with coronary artery disease
13) Confidence 0.50 Published 2010 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2875860 Disease Relevance 0.22 Pain Relevance 0
Exogenous E-cadherin and endogenous N-cadherin were successfully detected on the plasma membrane of hormone-producing cells that were transfected with rE-cad-IZ (Fig. 1D, 1F, 1H, and 1J).
Gene_expression (detected) of E-cadherin in plasma associated with coronary artery disease
14) Confidence 0.45 Published 2010 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2875860 Disease Relevance 0.51 Pain Relevance 0
Using in situ hybridization and immunocytochemical techniques, we utilized lactotrophs to examine whether forced E-cadherin expression by gene transfection affects prolactin mRNA expression and prolactin production.


Gene_expression (expression) of E-cadherin in lactotrophs
15) Confidence 0.45 Published 2010 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2875860 Disease Relevance 0.09 Pain Relevance 0.09
These results suggest that the expression of E-cadherin does not affect prolactin mRNA transcription; rather, it reduces prolactin protein content, presumably by affecting trafficking of secretory granules.



Gene_expression (expression) of E-cadherin
16) Confidence 0.45 Published 2010 Journal Acta Histochemica et Cytochemica Section Abstract Doc Link PMC2875860 Disease Relevance 0.31 Pain Relevance 0
This is the first report to show forced expression of E-cadherin in rat anterior pituitary cells and its effects on hormone production.
Gene_expression (expression) of E-cadherin in anterior pituitary
17) Confidence 0.45 Published 2010 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2875860 Disease Relevance 0.45 Pain Relevance 0
E-cadherin was detected on the plasma membrane of rE-cad-IZ-transfected cells (indicated by the small arrow in Fig. 1J) and in the cytoplasm of hormone-producing cells.
Gene_expression (detected) of E-cadherin in plasma associated with coronary artery disease
18) Confidence 0.45 Published 2010 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2875860 Disease Relevance 0.42 Pain Relevance 0
In the present study, we examined the roles of cadherin switching in cytogenesis of anterior pituitary cells by observing prolactin mRNA and protein expression in lactotrophs that were transformed with an E-cadherin expression vector.
Gene_expression (expression) of E-cadherin in lactotrophs
19) Confidence 0.45 Published 2010 Journal Acta Histochemica et Cytochemica Section Abstract Doc Link PMC2875860 Disease Relevance 0.31 Pain Relevance 0
These findings suggest that an investigation of the experimental expression of E-cadherin in mature hormone-producing cells might increase our understanding of the roles of cadherin switching in the cytogenesis of anterior pituitary cells.
Gene_expression (expression) of E-cadherin in anterior pituitary
20) Confidence 0.45 Published 2010 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2875860 Disease Relevance 0.05 Pain Relevance 0.06

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